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Methyltestosterone Brand Names
Android | Methitest | Testred | Virilon
What is Methyltestosterone
Methyltestosterone was developed synthetically in the search for an androgen that could be given orally, without loss of bioavailability.
Mehyltestosterone is structurally similar to testosterone, except it is methylated at 17 position, which is associated with less hepatic metabolism following oral administration when compared to testosterone.
Methyltestosterone is used in the management of congenital or acquired hypogonadism.
Methyltestosterone may be considered appropriate therapy for pathological, delayed puberty, and it is effective as palliative treatment for carcinoma of the breast in postmenopausal women, acting as an antiestrogen.
Anabolic steroids have been the subject of drug misuse and abuse, often producing adverse effects such as changes in libido, hepatotoxicity, increased risk of cardiovascular disease, and antisocial behavior.
Some of the masculinizing effects in women can be irreversible.
Methyltestosterone was first approved as a topical ointment (which has been withdrawn from the market) by the FDA in 1939.
Oral forms became available beginning in 1940 and became a controlled substance in 1991.
Indications
- andropause
- cryptorchidism
- delayed puberty
- erectile dysfunction (ED)
- hypogonadism
- palliative treatment of breast cancer
For androgen replacement therapy, including symptoms consistent with andropause, erectile dysfunction (ED), or hypogonadism
Side Effects
- acne vulgaris
- alopecia
- amenorrhea
- anaphylactoid reactions
- anxiety
- bleeding
- clitoromegaly
- depression
- dysphonia
- elevated hepatic enzymes
- epididymitis
- epiphyseal closure
- erythrocytosis
- feminization
- fluid retention
- gynecomastia
- headache
- hepatitis
- hirsutism
- hypercalcemia
- hypercholesterolemia
- jaundice
- libido decrease
- libido increase
- nausea
- new primary malignancy
- oligomenorrhea
- paresthesias
- peliosis hepatis
- peripheral edema
- polycythemia
- priapism
- prostatic hypertrophy
- pulmonary embolism
- thromboembolism
- thrombosis
- virilization
- vomiting
- weight gain
Monitoring Parameters
- LFTs
Contraindications
- breast cancer
- breast-feeding
- cardiac disease
- children
- coronary artery disease
- diabetes mellitus
- geriatric
- heart failure
- hepatic disease
- hypercalcemia
- myocardial infarction
- pregnancy
- prostate cancer
- prostatic hypertrophy
- renal disease
Interactions
- Abarelix
- Acarbose
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Betrixaban
- Bivalirudin
- Canagliflozin
- Canagliflozin; Metformin
- Cyclosporine
- Dabigatran
- Dalteparin
- Danaparoid
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darbepoetin Alfa
- Degarelix
- Desirudin
- Dipeptidyl Peptidase-4 Inhibitors
- Edoxaban
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enoxaparin
- Epoetin Alfa
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Fondaparinux
- Glipizide; Metformin
- Glyburide; Metformin
- Goserelin
- Heparin
- Histrelin
- Imipramine
- Incretin Mimetics
- Insulins
- Lepirudin
- Leuprolide
- Leuprolide; Norethindrone
- Linagliptin
- Linagliptin; Metformin
- Meglitinides
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methotrexate
- Methoxy polyethylene glycol-epoetin beta
- Miglitol
- Nafarelin
- Pentosan
- Pramlintide
- Rivaroxaban
- Saw Palmetto, Serenoa repens
- Saxagliptin
- SGLT2 Inhibitors
- Simvastatin; Sitagliptin
- Sitagliptin
- Sulfonylureas
- Thiazolidinediones
- Tinzaparin
- Triptorelin
- Warfarin
