What's on this Page
Methylene Blue Brand Names- PROVAYBLUE | Urolene Blue
What is Methylene Blue
Methylene blue is a water-soluble thiazine dye for acquired methemoglobinemia.
Other uses include bacteriological staining, as an indicator dye, and as a tracer in the evaluation of gastrointestinal fistulas.
Methylene blue carries a black box warning for the risk of serotonin syndrome with concomitant use of serotonergic medications; concurrent use of serotonergic medications should be avoided
Indications
- gastrointestinal fistula diagnosis
- hypotension
- lymphography
- methemoglobinemia
- neurotoxicity prophylaxis
- parathyroid gland localization
- sentinel lymph node mapping
- septic shock
For use as a diagnostic aid to determine the presence of a gastrointestinal fistula (e.g., gastrointestinal fistula diagnosis)
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- anorexia
- anxiety
- arthralgia
- arthralgia
- back pain
- blurred vision
- chest pain (unspecified)
- chills
- contact dermatitis
- diarrhea
- dizziness
- dizziness
- dysgeusia
- dysgeusia
- dyspnea
- dysuria
- ecchymosis
- edema
- elevated hepatic enzymes
- erythema
- flatulence
- headache
- headache
- hemolysis
- hot flashes
- hot flashes
- hyperbilirubinemia
- hyperhidrosis
- hyperhidrosis
- hypertension
- hypoesthesia
- influenza
- influenza
- infusion-related reactions
- methemoglobinemia
- muscle cramps
- muscle cramps
- musculoskeletal pain
- myalgia
- nasal congestion
- nausea
- nausea
- pallor
- palpitations
- paresthesias
- peripheral edema
- photosensitivity
- pruritus
- pruritus
- rhinorrhea
- serotonin syndrome
- sinus tachycardia
- skin discoloration
- sneezing
- syncope
- urine discoloration
- urticaria
- vomiting
- vomiting
- xerostomia
Monitoring Parameters
- ECG
- methemoglobin
Contraindications
- anemia
- breast-feeding
- driving or operating machinery
- G6PD deficiency
- geriatric
- hepatic disease
- intrathecal administration
- MAOI therapy
- pregnancy
- renal failure
- renal impairment
- subcutaneous administration
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Alfentanil
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Benzphetamine
- Bromocriptine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Caffeine; Ergotamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Citalopram
- Clomipramine
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Desipramine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Dolasetron
- Doxepin
- Duloxetine
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Escitalopram
- Fenfluramine
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Imipramine
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Lasmiditan
- Levomilnacipran
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lithium
- Lorcaserin
- Maprotiline
- Meperidine
- Meperidine; Promethazine
- Methadone
- Methamphetamine
- Methoxsalen
- Methylergonovine
- Methylphenidate
- Methysergide
- Milnacipran
- Mirtazapine
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nalbuphine
- Nefazodone
- Netupitant, Fosnetupitant; Palonosetron
- Nortriptyline
- Ondansetron
- Oxycodone
- Oxymorphone
- Ozanimod
- Palonosetron
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Pergolide
- Perphenazine; Amitriptyline
- Phenelzine
- Porfimer
- Procarbazine
- Protriptyline
- Rasagiline
- Remifentanil
- Safinamide
- Selegiline
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Tapentadol
- Tramadol
- Tranylcypromine
- Trazodone
- Trimipramine
- Venlafaxine
- Verteporfin
- Vilazodone
- Vortioxetine
