Mesoridazine

Mesoridazine Brand Name– Serentil

What is Mesoridazine

NOTE: This drug is discontinued in the US.

Mesoridazine is a phenothiazine antipsychotic agent used for the symptomatic management of psychotic disorders.

Similar to other low potency antipsychotics, mesoridazine has a high incidence of sedation and anticholinergic effects and a low incidence of extrapyramidal reactions. Like its parent compound thioridazine, mesoridazine can produce a variety of adverse cardiovascular effects.

Dose-related effects on ventricular repolarization may lead to QTc interval prolongation. Because of potential cardiovascular risks including torsade de pointes and sudden death, the manufacturer recommends that mesoridazine therapy be reserved for treating schizophrenic patients who have failed to respond to adequate courses of other antipsychotic drugs, either because of inadequate efficacy or intolerable side effects.

Serentil® was approved by the FDA in 1970.

Indications

  • behavioral or psychological symptoms of dementia
  • schizophrenia

For the treatment of schizophrenia

Side Effects

  1. agranulocytosis
  2. akathisia
  3. anaphylactoid reactions
  4. angina
  5. angioedema
  6. aplastic anemia
  7. asphyxia
  8. ataxia
  9. cardiac arrest
  10. cholestasis
  11. constipation
  12. contact dermatitis
  13. corneal opacification
  14. dizziness
  15. drowsiness
  16. dysarthria
  17. dystonic reaction
  18. ejaculation dysfunction
  19. eosinophilia
  20. erythema
  21. exfoliative dermatitis
  22. fever
  23. galactorrhea
  24. gynecomastia
  25. hemolytic anemia
  26. hepatitis
  27. hyperprolactinemia
  28. hyperthermia
  29. hyponatremia
  30. hypotension
  31. hypothermia
  32. impotence (erectile dysfunction)
  33. jaundice
  34. laryngeal edema
  35. leukopenia
  36. lupus-like symptoms
  37. menstrual irregularity
  38. miosis
  39. nasal congestion
  40. nausea
  41. neuroleptic malignant syndrome
  42. neutropenia
  43. pancytopenia
  44. photophobia
  45. photosensitivity
  46. polydipsia
  47. priapism
  48. pruritus
  49. pseudoparkinsonism
  50. purpura
  51. QT prolongation
  52. rash
  53. SIADH
  54. sinus tachycardia
  55. syncope
  56. tardive dyskinesia
  57. thrombocytopenia
  58. torsade de pointes
  59. torticollis
  60. trismus
  61. urinary incontinence
  62. urinary retention
  63. urticaria
  64. vomiting
  65. water intoxication
  66. weakness
  67. xerostomia

Monitoring Parameters

  • AIMS assessment
  • CBC
  • ECG
  • ophthalmologic exam
  • serum prolactin

Contraindications

  • abrupt discontinuation
  • agranulocytosis
  • alcoholism
  • ambient temperature increase
  • anticholinergic medications
  • bone marrow suppression
  • breast cancer
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • chemotherapy
  • children
  • closed-angle glaucoma
  • CNS depression
  • coadministration with other CNS depressants
  • coma
  • coronary artery disease
  • dehydration
  • dementia
  • dental work
  • diabetes mellitus
  • driving or operating machinery
  • dysphagia
  • electroconvulsive therapy (ECT)
  • electrolyte imbalance
  • ethanol ingestion
  • females
  • fever
  • geriatric
  • GI obstruction
  • head trauma
  • hematological disease
  • hepatic disease
  • hyperprolactinemia
  • hyperthermia
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypotension
  • hypothermia
  • ileus
  • infants
  • infection
  • infertility
  • intravenous administration
  • jaundice
  • labor
  • leukopenia
  • malnutrition
  • neonates
  • neurological disease
  • neutropenia
  • obstetric delivery
  • orthostatic hypotension
  • Parkinson’s disease
  • phenothiazine hypersensitivity
  • pregnancy
  • pregnancy testing
  • prostatic hypertrophy
  • QT prolongation
  • radiographic contrast administration
  • respiratory depression
  • Reye’s syndrome
  • seizure disorder
  • seizures
  • strenuous exercise
  • stroke
  • sunlight (UV) exposure
  • surgery
  • tardive dyskinesia
  • thyroid disease
  • tobacco smoking
  • torsade de pointes
  • urinary retention
  • visual impairment
  • vomiting

Interactions

  • Abarelix
  • Acarbose
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
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  • Acetaminophen; Dextromethorphan; Phenylephrine
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  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
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