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What is Meperidine and Promethazine
Meperidine and promethazine are used together in an oral preparation to treat pain. Meperidine hydrochloride is a synthetic opiate agonist belonging to the phenylpiperidine class.
Other members of the phenylpiperidine group include alfentanil, diphenoxylate, fentanyl, loperamide, and sufentanil. The chemical structure of meperidine is similar to local anesthetics.
Meperidine is recommended for relief of moderate to severe acute pain and has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B.
Meperidine is considered a second-line agent for the treatment of acute pain. Promethazine is a phenothiazine derivative; however, it is not used clinically as a neuroleptic.
Promethazine exhibits significant antihistaminic (H1-blocker) activity with considerable anticholinergic, sedative, and antiemetic effects and some local anesthetic properties.
In November 2004, the FDA directed manufacturers of promethazine-containing products to include a boxed warning contraindicating use in children and infants less than 2 years of age due to an increased risk for fatal respiratory depression.
Meperidine and promethazine products should be used with considerable caution in pediatric patients 2 years of age and older.
Meperidine and promethazine combination products were originally approved by the FDA in November 1961.
Indications
- moderate pain
- severe pain
Side Effects
- adrenocortical insufficiency
- agranulocytosis
- akathisia
- amenorrhea
- anxiety
- aplastic anemia
- blurred vision
- bradycardia
- cardiac arrest
- cholestasis
- coma
- confusion
- constipation
- corneal opacification
- delirium
- depression
- dizziness
- drowsiness
- dysphoria
- dystonic reaction
- eosinophilia
- euphoria
- fever
- flushing
- galactorrhea
- gonadal suppression
- hallucinations
- headache
- hemolytic anemia
- hyperamylasemia
- hypertension
- hyperthermia
- hyponatremia
- hypothermia
- ileus
- impaired cognition
- impotence (erectile dysfunction)
- infertility
- insomnia
- jaundice
- leukopenia
- libido decrease
- mastalgia
- menstrual irregularity
- miosis
- mydriasis
- myoclonia
- nausea
- neonatal abstinence syndrome
- neuroleptic malignant syndrome
- neutropenia
- orthostatic hypotension
- palpitations
- pancytopenia
- photosensitivity
- physiological dependence
- platelet dysfunction
- priapism
- pruritus
- pseudoparkinsonism
- purpura
- respiratory arrest
- respiratory depression
- restlessness
- retinopathy
- seizures
- serotonin syndrome
- SIADH
- skin hyperpigmentation
- syncope
- tardive dyskinesia
- thrombocytopenia
- tolerance
- tremor
- urinary retention
- visual impairment
- vomiting
- weight gain
- withdrawal
- xerophthalmia
- xerostomia
Monitoring Parameters
- CBC with differential
- LFTs
- serum creatinine/BUN
Contraindications
- acute abdomen
- acute bronchospasm
- adrenal insufficiency
- agranulocytosis
- alcoholism
- angina
- asthma
- atrial flutter
- biliary tract disease
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- coma
- constipation
- contact lenses
- dehydration
- diarrhea
- driving or operating machinery
- ethanol intoxication
- geriatric
- GI disease
- GI obstruction
- glaucoma
- head trauma
- heart failure
- hepatic disease
- hypotension
- hypothyroidism
- hypovolemia
- ileus
- increased intracranial pressure
- infants
- inflammatory bowel disease
- jaundice
- labor
- lactase deficiency
- MAOI therapy
- myxedema
- neonates
- obstetric delivery
- oliguria
- opiate agonist hypersensitivity
- opioid overdose
- opioid use disorder
- phenothiazine hypersensitivity
- pheochromocytoma
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- radiographic contrast administration
- renal disease
- renal failure
- renal impairment
- respiratory depression
- respiratory insufficiency
- Reye’s syndrome
- seizure disorder
- seizures
- sleep apnea
- substance abuse
- ulcerative colitis
- urinary retention
Interactions
- Abarelix
- Acarbose
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acetohexamide
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Alprazolam
- Alvimopan
- Amantadine
- Amide local anesthetics
- Amifampridine
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Aminolevulinic Acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Anagrelide
- Anticholinergics
- Anxiolytics; Sedatives; and Hypnotics
- Apomorphine
- Apraclonidine
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Azithromycin
- Baclofen
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzonatate
- Benzphetamine
- Benztropine
- Bepridil
- Bethanechol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brexpiprazole
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bumetanide
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Cabergoline
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capsaicin; Metaxalone
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Carteolol
- Celecoxib
- Cenobamate
- Central-acting adrenergic agents
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Cetrorelix
- Cevimeline
- Charcoal
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloral Hydrate
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chloroquine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Cimetidine
- Cinacalcet
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clemastine
- Clindamycin; Tretinoin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clonidine
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Crizotinib
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darifenacin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Desmopressin
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dexpanthenol
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Quinidine
- Diazepam
- Dicyclomine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dutasteride; Tamsulosin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Enflurane
- Entrectinib
- Epinephrine
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eribulin
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etomidate
- Ezogabine
- Felbamate
- Fenfluramine
- Fentanyl
- Fesoterodine
- Fingolimod
- Flavoxate
- Flecainide
- Flibanserin
- Fluconazole
- Flucytosine
- Fluocinolone; Hydroquinone; Tretinoin
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluvoxamine
- food
- Foscarnet
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Furosemide
- Gabapentin
- Galantamine
- Ganirelix
- Gemifloxacin
- Gemtuzumab Ozogamicin
- General anesthetics
- Gentamicin
- Gilteritinib
- Glasdegib
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guanabenz
- Guanfacine
- Guanidine
- Halobetasol; Tazarotene
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Ibutilide
- Iloperidone
- Imipramine
- Incretin Mimetics
- Indacaterol; Glycopyrrolate
- Indapamide
- Inotuzumab Ozogamicin
- Insulins
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Ipecac
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosulfan Blue
- Itraconazole
- Ivosidenib
- Kanamycin
- Ketamine
- Ketoconazole
- Lamotrigine
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levetiracetam
- Levobupivacaine
- Levocetirizine
- Levodopa
- Levofloxacin
- Levomethadyl
- Levorphanol
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Lincosamides
- Linezolid
- Lisdexamfetamine
- Lithium
- Lofexidine
- Lomefloxacin
- Long-acting beta-agonists
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Lorcaserin
- Loxapine
- Lumateperone
- Lurasidone
- Macimorelin
- Magnesium Salts
- Maprotiline
- Meclizine
- Mefloquine
- Meglitinides
- Melatonin
- Mepenzolate
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Meprobamate
- Mequinol; Tretinoin
- Mesoridazine
- Mestranol; Norethindrone
- Metaxalone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methohexital
- Methoxsalen
- Methscopolamine
- Methsuximide
- Methyclothiazide
- Methyldopa
- Methylene Blue
- Methylphenidate
- Metoclopramide
- Metolazone
- Metoprolol
- Metronidazole
- Metyrapone
- Metyrosine
- Midazolam
- Midostaurin
- Mifepristone
- Miglitol
- Minocycline
- Mirabegron
- Mirtazapine
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Nabilone
- Nadolol
- Nafarelin
- Nalbuphine
- Naloxone
- Naltrexone
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nesiritide, BNP
- Nilotinib
- Nitroglycerin
- Non-Ionic Contrast Media
- Norepinephrine
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Palonosetron
- Panobinostat
- Papaverine
- Paromomycin
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Pegvisomant
- Pemoline
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Pergolide
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pilocarpine
- Pimavanserin
- Pimozide
- Pioglitazone
- Pitolisant
- Plazomicin
- Porfimer
- Posaconazole
- Pramipexole
- Pramlintide
- Prasugrel
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Procainamide
- Procaine
- Procarbazine
- Prochlorperazine
- Propafenone
- Propantheline
- Propofol
- Propoxyphene
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Rasagiline
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Rilpivirine
- Risperidone
- Ritodrine
- Ritonavir
- Rivastigmine
- Rolapitant
- Romidepsin
- Ropinirole
- Ropivacaine
- Rosiglitazone
- Rotigotine
- Safinamide
- Saquinavir
- Saxagliptin
- Scopolamine
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Selegiline
- Selpercatinib
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Serotonin-Receptor Antagonists
- Sertraline
- Sevoflurane
- SGLT2 Inhibitors
- Short-acting beta-agonists
- Sibutramine
- Sildenafil
- Simvastatin; Sitagliptin
- Siponimod
- Sitagliptin
- Sodium Oxybate
- Solifenacin
- Sorafenib
- Sotalol
- Sparfloxacin
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptomycin
- Sufentanil
- Sulfonylureas
- Sunitinib
- Suvorexant
- Tacrolimus
- Tamoxifen
- Tamsulosin
- Tapentadol
- Tasimelteon
- Tazarotene
- Tedizolid
- Telavancin
- Telithromycin
- Temazepam
- Teniposide
- Terbinafine
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiazide diuretics
- Thiazolidinediones
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Tiagabine
- Ticagrelor
- Timolol
- Tipranavir
- Tizanidine
- tobacco
- Tobramycin
- Tolazamide
- Tolbutamide
- Tolterodine
- Topiramate
- Toremifene
- Torsemide
- Tramadol
- Trazodone
- Tretinoin, ATRA
- Triamterene
- Triazolam
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Triptorelin
- Trospium
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Verteporfin
- Vigabatrin
- Vilazodone
- Voriconazole
- Vorinostat
- Vortioxetine
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
- Zonisamide