Memantine Brand Names- Namenda | Namenda XR
What is Memantine
Memantine is an oral, N-methyl-D-aspartate (NMDA) receptor antagonist.
Memantine is indicated for the treatment of moderate to severe Alzheimer’s disease (AD) both as monotherapy and in combination with donepezil, an acetylcholinesterase inhibitor.
Limited data suggest that memantine may be beneficial for the symptomatic treatment of acquired pendular nystagmus; however, further evaluation is required.
In addition to having a mechanism of action distinct from other drugs used to treat cognitive impairment, memantine is predominantly eliminated by the kidneys in part by tubular secretion.
Medical co-existing conditions, or the use of selected drugs or foods that raise urine pH may decrease urinary elimination of memantine and increase plasma concentrations, potentially increasing the risk of adverse effects. The FDA first approved memantine in 2003.
Indications
- Alzheimer’s disease
- nystagmus
For the treatment of symptoms of moderate to severe Alzheimer’s disease
Side Effects
- abdominal pain
- agitation
- agranulocytosis
- anxiety
- back pain
- confusion
- constipation
- cough
- depression
- diarrhea
- dizziness
- drowsiness
- dyspnea
- fatigue
- fever
- hallucinations
- headache
- heart failure
- hepatitis
- hypertension
- hypotension
- influenza
- irritability
- leukopenia
- neutropenia
- pancreatitis
- pancytopenia
- pharyngitis
- rash
- renal failure (unspecified)
- rhinorrhea
- seizures
- Stevens-Johnson syndrome
- suicidal ideation
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- toxic epidermal necrolysis
- urinary incontinence
- vomiting
- weight gain
Monitoring Parameters
- neurologic function
- serum creatinine
Contraindications
- breast-feeding
- children
- geriatric
- hepatic disease
- infants
- pregnancy
- renal failure
- renal impairment
- renal tubular acidosis (RTA)
- urinary tract infection (UTI)
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetazolamide
- Adefovir
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Alogliptin; Metformin
- Amantadine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Anticholinergics
- Benazepril; Hydrochlorothiazide, HCTZ
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bromocriptine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbonic anhydrase inhibitors
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Cimetidine
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Clofarabine
- Dapagliflozin; Metformin
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Digoxin
- Dofetilide
- Dolutegravir; Lamivudine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Hydrochlorothiazide, HCTZ
- Entecavir
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Fosinopril; Hydrochlorothiazide, HCTZ
- Glipizide; Metformin
- Glyburide; Metformin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Ketamine
- Lamivudine, 3TC
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Linagliptin; Metformin
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methazolamide
- Midodrine
- Morphine
- Morphine; Naltrexone
- Nicotine
- Pergolide
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Procainamide
- Quinidine
- Quinine
- Ranitidine
- Ropinirole
- Rotigotine
- Solifenacin
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Triamterene
- Trimethoprim
- Trospium
- Vancomycin
