Memantine

Memantine Brand Names- Namenda | Namenda XR

What is Memantine

Memantine is an oral, N-methyl-D-aspartate (NMDA) receptor antagonist.

Memantine is indicated for the treatment of moderate to severe Alzheimer’s disease (AD) both as monotherapy and in combination with donepezil, an acetylcholinesterase inhibitor.

Limited data suggest that memantine may be beneficial for the symptomatic treatment of acquired pendular nystagmus; however, further evaluation is required.

In addition to having a mechanism of action distinct from other drugs used to treat cognitive impairment, memantine is predominantly eliminated by the kidneys in part by tubular secretion.

Medical co-existing conditions, or the use of selected drugs or foods that raise urine pH may decrease urinary elimination of memantine and increase plasma concentrations, potentially increasing the risk of adverse effects. The FDA first approved memantine in 2003.

Indications

  • Alzheimer’s disease
  • nystagmus

For the treatment of symptoms of moderate to severe Alzheimer’s disease

Side Effects

  1. abdominal pain
  2. agitation
  3. agranulocytosis
  4. anxiety
  5. back pain
  6. confusion
  7. constipation
  8. cough
  9. depression
  10. diarrhea
  11. dizziness
  12. drowsiness
  13. dyspnea
  14. fatigue
  15. fever
  16. hallucinations
  17. headache
  18. heart failure
  19. hepatitis
  20. hypertension
  21. hypotension
  22. influenza
  23. irritability
  24. leukopenia
  25. neutropenia
  26. pancreatitis
  27. pancytopenia
  28. pharyngitis
  29. rash
  30. renal failure (unspecified)
  31. rhinorrhea
  32. seizures
  33. Stevens-Johnson syndrome
  34. suicidal ideation
  35. thrombocytopenia
  36. thrombotic thrombocytopenic purpura (TTP)
  37. toxic epidermal necrolysis
  38. urinary incontinence
  39. vomiting
  40. weight gain

Monitoring Parameters

  • neurologic function
  • serum creatinine

Contraindications

  • breast-feeding
  • children
  • geriatric
  • hepatic disease
  • infants
  • pregnancy
  • renal failure
  • renal impairment
  • renal tubular acidosis (RTA)
  • urinary tract infection (UTI)

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Abacavir; Lamivudine, 3TC
  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetazolamide
  • Adefovir
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alkalinizing Agents
  • Alogliptin; Metformin
  • Amantadine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Anticholinergics
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bromocriptine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbonic anhydrase inhibitors
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Cimetidine
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Clofarabine
  • Dapagliflozin; Metformin
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Digoxin
  • Dofetilide
  • Dolutegravir; Lamivudine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Entecavir
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin; Metformin
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Ketamine
  • Lamivudine, 3TC
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Linagliptin; Metformin
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methazolamide
  • Midodrine
  • Morphine
  • Morphine; Naltrexone
  • Nicotine
  • Pergolide
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Procainamide
  • Quinidine
  • Quinine
  • Ranitidine
  • Ropinirole
  • Rotigotine
  • Solifenacin
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Triamterene
  • Trimethoprim
  • Trospium
  • Vancomycin