Meclofenamate Sodium

What is Meclofenamate Sodium

Meclofenamate Sodium is a member of the anthranilic acid (fenamate) group of nonsteroidal anti-inflammatory drugs (NSAIDs);mefenamic acid is also a member of the fenamate class of NSAIDs.

Meclofenamate is used in the treatment of mild to moderate pain including dysmenorrhea and arthritis.

Like other NSAIDs, meclofenamate may cause an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.

The lowest effective dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.

Meclofenamate was FDA-approved in June 1980.

Indications

1. dysmenorrhea
2. headache
3. migraine
4. mild pain
5. moderate pain
6. osteoarthritis
7. rheumatoid arthritis

For the treatment of dysmenorrhea

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. anaphylactoid reactions
5. anemia
6. angioedema
7. anorexia
8. aplastic anemia
9. aseptic meningitis
10. azotemia
11. blurred vision
12. cholestasis
13. colitis
14. conjunctivitis
15. constipation
16. cystitis
17. depression
18. diarrhea
19. dizziness
20. dysgeusia
21. dyspepsia
22. dysphagia
23. dysuria
24. edema
25. elevated hepatic enzymes
26. eosinophilia
27. erythema multiforme
28. esophageal stricture
29. esophageal ulceration
30. esophagitis
31. exfoliative dermatitis
32. fatigue
33. flatulence
34. gastritis
35. GI bleeding
36. GI perforation
37. headache
38. hearing loss
39. heart failure
40. hematemesis
41. hematuria
42. hemolytic anemia
43. hepatic failure
44. hepatic necrosis
45. hepatitis
46. hyperkalemia
47. hypertension
48. hyperuricemia
49. hyponatremia
50. ileus
51. insomnia
52. interstitial nephritis
53. iritis
54. jaundice
55. leukopenia
56. lupus-like symptoms
57. macular edema
58. malaise
59. melena
60. myocardial infarction
61. nausea
62. nephrotic syndrome
63. neutropenia
64. nocturia
65. odynophagia
66. oliguria
67. palpitations
68. paresthesias
69. peptic ulcer
70. platelet dysfunction
71. polyuria
72. proteinuria
73. pruritus
74. purpura
75. pyrosis (heartburn)
76. rash
77. renal failure (unspecified)
78. renal papillary necrosis
79. serum sickness
80. Stevens-Johnson syndrome
81. stomatitis
82. stroke
83. thrombocytopenia
84. thromboembolism
85. tinnitus
86. toxic epidermal necrolysis
87. urticaria
88. visual impairment
89. vomiting

Monitoring Parameters

• CBC
• LFTs
• serum creatinine/BUN
• stool guaiac

Contraindications

• acute bronchospasm
• acute myocardial infarction
• alcoholism
• anemia
• angina
• anticoagulant therapy
• asthma
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• chemotherapy
• children
• coagulopathy
• coronary artery bypass graft surgery (CABG)
• coronary artery disease
• corticosteroid therapy
• dehydration
• diabetes mellitus
• edema
• females
• geriatric
• GI bleeding
• GI disease
• GI perforation
• heart failure
• hematological disease
• hemophilia
• hepatic disease
• hypertension
• hypoalbuminemia
• hypovolemia
• immunosuppression
• infants
• intracranial bleeding
• intramuscular injections
• jaundice
• labor
• myocardial infarction
• nasal polyps
• neonates
• neutropenia
• NSAID hypersensitivity
• obstetric delivery
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• renal disease
• renal failure
• renal impairment
• rheumatoid arthritis
• salicylate hypersensitivity
• stroke
• surgery
• systemic lupus erythematosus (SLE)
• tachycardia
• thrombocytopenia
• thromboembolism
• tobacco smoking
• ulcerative colitis
• urticaria

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