Measles Mumps Rubella Varicella Vaccine Live

Measles Mumps Rubella Varicella Vaccine Live Brand Name– ProQuad

What is Measles Mumps Rubella Varicella Vaccine Live

Measles Mumps Rubella Varicella Vaccine Live is a combination subcutaneous injection consisting of four live, attenuated virus vaccinations intended to confer immunity against measles (rubeola), mumps, varicella (chickenpox), and rubella (German measles) viruses in susceptible children 12 months to 12 years of age.

The measles component consists of the Ender’s line measles virus obtained from the attenuated Edmonston strain cultured from chick embryos.

The mumps component consists of the Jeryl Lynn™ strain cultured from chick embryos.

The rubella component consists of the Wistar Institute RA 27/3 strain of rubella virus propagated in human diploid [WI-38] cells, and the varicella component consists of the Oka/Merck strain of varicella-zoster virus propagated in MRC-5 cells. The 2008 recommended immunization schedule for children and adolescents includes 2 doses of measles, mumps, and rubella vaccine and 2 doses of the varicella vaccine.

Use of the combined measles, mumps, rubella, and varicella vaccine may prevent the need for 3 injections; the combined vaccine can be used to confer immunity against varicella.

The antibody responses to each of the antigens in ProQuad® were similar as compared with the responses after a single dose of the measles, mumps, and rubella vaccine and of Varivax® (varicella virus vaccine) given at separate injection sites.

A second dose of ProQuad® may be administered regardless of whether varicella immunity is present either from vaccination or disease acquisition (see Dosage).

The FDA approved Proquad® in September 2005.

A refrigerator-stable formulation is FDA-approved, but the commercial availability date in the US is unknown.

Indications

  1. measles prophylaxis
  2. mumps prophylaxis
  3. rubella prophylaxis
  4. varicella (chickenpox) infection prophylaxis

For measles prophylaxis, mumps prophylaxis, rubella prophylaxis, and varicella (chickenpox) infection prophylaxis

Side Effects

  1. abdominal pain
  2. abnormal dreams
  3. acute disseminated encephalomyelitis
  4. agitation
  5. anaphylactic shock
  6. anaphylactoid reactions
  7. angioedema
  8. aplastic anemia
  9. arthralgia
  10. aseptic meningitis
  11. ataxia
  12. blepharedema
  13. bronchospasm
  14. candidiasis
  15. cough
  16. diarrhea
  17. dizziness
  18. drowsiness
  19. ecchymosis
  20. encephalopathy
  21. epididymitis
  22. epistaxis
  23. erythema
  24. erythema multiforme
  25. fever
  26. flatulence
  27. Guillain-Barre syndrome
  28. headache
  29. hearing loss
  30. infection
  31. influenza
  32. injection site reaction
  33. irritability
  34. lymphadenopathy
  35. meningitis
  36. musculoskeletal pain
  37. myalgia
  38. myelitis
  39. nausea
  40. ocular irritation
  41. optic neuritis
  42. oral ulceration
  43. otalgia
  44. panniculitis
  45. paresthesias
  46. parotitis
  47. peripheral edema
  48. pharyngitis
  49. photosensitivity
  50. pneumonitis
  51. pruritus
  52. purpura
  53. rash
  54. rhinitis
  55. rhinorrhea
  56. seizures
  57. sinusitis
  58. sneezing
  59. Stevens-Johnson syndrome
  60. syncope
  61. throat irritation
  62. thrombocytopenia
  63. tremor
  64. vesicular rash
  65. vomiting
  66. wheezing

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acquired immunodeficiency syndrome (AIDS)
  • agammaglobulinemia
  • albumin hypersensitivity
  • bone marrow suppression
  • breast-feeding
  • chemotherapy
  • egg hypersensitivity
  • fever
  • gelatin hypersensitivity
  • geriatric
  • human immunodeficiency virus (HIV) infection
  • hypogammaglobulinemia
  • IgA deficiency
  • immunosuppression
  • infants
  • infection
  • intramuscular administration
  • intravenous administration
  • leukemia
  • lymphoma
  • neomycin hypersensitivity
  • neoplastic disease
  • pregnancy
  • radiation therapy
  • seizure disorder
  • severe combined immunodeficiency (SCID)
  • thrombocytopenia
  • tuberculosis
  • viral infection

Interactions

  • Abatacept
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acyclovir
  • Adalimumab
  • Aldesleukin, IL-2
  • Alefacept
  • Alemtuzumab
  • Alkylating agents
  • Alpha interferons
  • Altretamine
  • Aminosalicylate sodium, Aminosalicylic acid
  • Anakinra
  • Antimetabolites
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Axicabtagene Ciloleucel
  • Azathioprine
  • Baricitinib
  • Basiliximab
  • Belatacept
  • Belimumab
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bexarotene
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Blinatumomab
  • Brodalumab
  • Busulfan
  • Canakinumab
  • Carmustine, BCNU
  • Certolizumab pegol
  • Chlorambucil
  • Choline Salicylate; Magnesium Salicylate
  • Cisplatin
  • Clofarabine
  • Cortisone
  • Crotalidae Polyvalent Immune Fab, Ovine
  • Cyclophosphamide
  • Cyclosporine
  • Cytarabine, ARA-C
  • Cytomegalovirus Immune Globulin, CMV-IGIV
  • Dacarbazine, DTIC
  • Daclizumab
  • Deflazacort
  • Dexamethasone
  • Digoxin Immune Fab
  • Docetaxel
  • Dupilumab
  • Efalizumab
  • Emapalumab
  • Estramustine
  • Etanercept
  • Everolimus
  • Famciclovir
  • Fingolimod
  • Floxuridine
  • Fludrocortisone
  • Fluorouracil, 5-FU
  • Folate analogs
  • Golimumab
  • Guselkumab
  • Hepatitis B Immune Globulin, HBIG
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydrocortisone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ifosfamide
  • Imatinib
  • Immune Globulin IV, IVIG, IGIV
  • Inebilizumab
  • Infliximab
  • Interferon Gamma-1b
  • Ixabepilone
  • Ixekizumab
  • Leflunomide
  • Lenalidomide
  • Lomustine, CCNU
  • Magnesium Salicylate
  • Mechlorethamine, Nitrogen Mustard
  • Melphalan
  • Methylprednisolone
  • Mitoxantrone
  • Muromonab-CD3
  • Mycophenolate
  • Natalizumab
  • Nelarabine
  • Nilotinib
  • Obinutuzumab
  • Ocrelizumab
  • Ofatumumab
  • Ozanimod
  • Paclitaxel
  • Prednisolone
  • Prednisone
  • Procarbazine
  • Purine analogs
  • Rabies Immune Globulin, human RIG
  • Respiratory Syncytial Virus Immune Globulin, RSV-IGIV
  • Rh0 [D] Immune Globulin
  • Rilonacept
  • Risankizumab
  • Rituximab
  • Rituximab; Hyaluronidase
  • Salicylates
  • Salsalate
  • Sarilumab
  • Secukinumab
  • Siltuximab
  • Siponimod
  • Sirolimus
  • Streptozocin
  • Tacrolimus
  • Temozolomide
  • Temsirolimus
  • Teriflunomide
  • Tetanus Immune Globulin, Human, TIG
  • Thiotepa
  • Tildrakizumab
  • Tisagenlecleucel
  • Tocilizumab
  • Tofacitinib
  • Tositumomab
  • Triamcinolone
  • Tuberculin Purified Protein Derivative, PPD
  • Ustekinumab
  • Valacyclovir
  • Varicella-Zoster Immune Globulin
  • Vedolizumab
  • Venetoclax
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine
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