Measles Mumps Rubella Varicella Vaccine Live Brand Name– ProQuad
What is Measles Mumps Rubella Varicella Vaccine Live
Measles Mumps Rubella Varicella Vaccine Live is a combination subcutaneous injection consisting of four live, attenuated virus vaccinations intended to confer immunity against measles (rubeola), mumps, varicella (chickenpox), and rubella (German measles) viruses in susceptible children 12 months to 12 years of age.
The measles component consists of the Ender’s line measles virus obtained from the attenuated Edmonston strain cultured from chick embryos.
The mumps component consists of the Jeryl Lynn™ strain cultured from chick embryos.
The rubella component consists of the Wistar Institute RA 27/3 strain of rubella virus propagated in human diploid [WI-38] cells, and the varicella component consists of the Oka/Merck strain of varicella-zoster virus propagated in MRC-5 cells. The 2008 recommended immunization schedule for children and adolescents includes 2 doses of measles, mumps, and rubella vaccine and 2 doses of the varicella vaccine.
Use of the combined measles, mumps, rubella, and varicella vaccine may prevent the need for 3 injections; the combined vaccine can be used to confer immunity against varicella.
The antibody responses to each of the antigens in ProQuad® were similar as compared with the responses after a single dose of the measles, mumps, and rubella vaccine and of Varivax® (varicella virus vaccine) given at separate injection sites.
A second dose of ProQuad® may be administered regardless of whether varicella immunity is present either from vaccination or disease acquisition (see Dosage).
The FDA approved Proquad® in September 2005.
A refrigerator-stable formulation is FDA-approved, but the commercial availability date in the US is unknown.
Indications
- measles prophylaxis
- mumps prophylaxis
- rubella prophylaxis
- varicella (chickenpox) infection prophylaxis
For measles prophylaxis, mumps prophylaxis, rubella prophylaxis, and varicella (chickenpox) infection prophylaxis
Side Effects
- abdominal pain
- abnormal dreams
- acute disseminated encephalomyelitis
- agitation
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- aplastic anemia
- arthralgia
- aseptic meningitis
- ataxia
- blepharedema
- bronchospasm
- candidiasis
- cough
- diarrhea
- dizziness
- drowsiness
- ecchymosis
- encephalopathy
- epididymitis
- epistaxis
- erythema
- erythema multiforme
- fever
- flatulence
- Guillain-Barre syndrome
- headache
- hearing loss
- infection
- influenza
- injection site reaction
- irritability
- lymphadenopathy
- meningitis
- musculoskeletal pain
- myalgia
- myelitis
- nausea
- ocular irritation
- optic neuritis
- oral ulceration
- otalgia
- panniculitis
- paresthesias
- parotitis
- peripheral edema
- pharyngitis
- photosensitivity
- pneumonitis
- pruritus
- purpura
- rash
- rhinitis
- rhinorrhea
- seizures
- sinusitis
- sneezing
- Stevens-Johnson syndrome
- syncope
- throat irritation
- thrombocytopenia
- tremor
- vesicular rash
- vomiting
- wheezing
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- agammaglobulinemia
- albumin hypersensitivity
- bone marrow suppression
- breast-feeding
- chemotherapy
- egg hypersensitivity
- fever
- gelatin hypersensitivity
- geriatric
- human immunodeficiency virus (HIV) infection
- hypogammaglobulinemia
- IgA deficiency
- immunosuppression
- infants
- infection
- intramuscular administration
- intravenous administration
- leukemia
- lymphoma
- neomycin hypersensitivity
- neoplastic disease
- pregnancy
- radiation therapy
- seizure disorder
- severe combined immunodeficiency (SCID)
- thrombocytopenia
- tuberculosis
- viral infection
Interactions
- Abatacept
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acyclovir
- Adalimumab
- Aldesleukin, IL-2
- Alefacept
- Alemtuzumab
- Alkylating agents
- Alpha interferons
- Altretamine
- Aminosalicylate sodium, Aminosalicylic acid
- Anakinra
- Antimetabolites
- Antithymocyte Globulin
- Antitumor antibiotics
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Axicabtagene Ciloleucel
- Azathioprine
- Baricitinib
- Basiliximab
- Belatacept
- Belimumab
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bexarotene
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Blinatumomab
- Brodalumab
- Busulfan
- Canakinumab
- Carmustine, BCNU
- Certolizumab pegol
- Chlorambucil
- Choline Salicylate; Magnesium Salicylate
- Cisplatin
- Clofarabine
- Cortisone
- Crotalidae Polyvalent Immune Fab, Ovine
- Cyclophosphamide
- Cyclosporine
- Cytarabine, ARA-C
- Cytomegalovirus Immune Globulin, CMV-IGIV
- Dacarbazine, DTIC
- Daclizumab
- Deflazacort
- Dexamethasone
- Digoxin Immune Fab
- Docetaxel
- Dupilumab
- Efalizumab
- Emapalumab
- Estramustine
- Etanercept
- Everolimus
- Famciclovir
- Fingolimod
- Floxuridine
- Fludrocortisone
- Fluorouracil, 5-FU
- Folate analogs
- Golimumab
- Guselkumab
- Hepatitis B Immune Globulin, HBIG
- Hyaluronidase, Recombinant; Immune Globulin
- Hydrocortisone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ifosfamide
- Imatinib
- Immune Globulin IV, IVIG, IGIV
- Inebilizumab
- Infliximab
- Interferon Gamma-1b
- Ixabepilone
- Ixekizumab
- Leflunomide
- Lenalidomide
- Lomustine, CCNU
- Magnesium Salicylate
- Mechlorethamine, Nitrogen Mustard
- Melphalan
- Methylprednisolone
- Mitoxantrone
- Muromonab-CD3
- Mycophenolate
- Natalizumab
- Nelarabine
- Nilotinib
- Obinutuzumab
- Ocrelizumab
- Ofatumumab
- Ozanimod
- Paclitaxel
- Prednisolone
- Prednisone
- Procarbazine
- Purine analogs
- Rabies Immune Globulin, human RIG
- Respiratory Syncytial Virus Immune Globulin, RSV-IGIV
- Rh0 [D] Immune Globulin
- Rilonacept
- Risankizumab
- Rituximab
- Rituximab; Hyaluronidase
- Salicylates
- Salsalate
- Sarilumab
- Secukinumab
- Siltuximab
- Siponimod
- Sirolimus
- Streptozocin
- Tacrolimus
- Temozolomide
- Temsirolimus
- Teriflunomide
- Tetanus Immune Globulin, Human, TIG
- Thiotepa
- Tildrakizumab
- Tisagenlecleucel
- Tocilizumab
- Tofacitinib
- Tositumomab
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Ustekinumab
- Valacyclovir
- Varicella-Zoster Immune Globulin
- Vedolizumab
- Venetoclax
- Vincristine
- Vincristine Liposomal
- Vinorelbine