Markers for bone remodeling
What markers are available to assess bone remodeling and how are they used?
|Bone formation||Bone resorption|
|Serum alkaline phosphatase||Urine or serum N-telopeptides (NTX)|
|Serum Osteocalcin||Serum C-telopeptides (CTX)|
Elevation of biomarkers predicts future bone loss. A 30% reduction of biomarkers after therapy is initiated verifies compliance and predicts an increase in bone mass. However, marked variability in biomarker measurement limits the utility of this tool. A serum CTX <312 ng/L and/or urine NTX <27nmol/mmolCr indicates good control.