Lovastatin Niacin Brand Name– Advicor
What is Lovastatin Niacin
Lovastatin niacin (Advicor™) is the first combination oral antilipemic agent introduced to the US market.
Advicor™ contains niacin (extended-release) and lovastatin (immediate-release). Lovastatin is an HMG-CoA reductase inhibitor, while niacin (nicotinic acid) is a B-complex vitamin.
Due to the individual actions of lovastatin and niacin, Advicor™ reduces LDL-cholesterol (30—42%) and triglycerides (32—44%), and increases HDL-cholesterol (20—30%).
The antilipemic effects of Advicor™ are dose-dependent and exceed the results attained by equivalent monotherapy doses of either niacin or lovastatin.
Advicor™ is not intended for first-line therapy. It is indicated for the treatment of primary hypercholesterolemia and mixed dyslipidemia in patients receiving lovastatin or niacin and who require further TG-lowering and/or HDL-raising.
Advicor™ was approved by the FDA on December 17, 2001.
Indications
- hypercholesterolemia
- hyperlipoproteinemia
For the treatment of primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Frederickson Types IIa and IIb hyperlipoproteinemia) in patients receiving lovastatin or niacin and who require further TG-lowering and/or HDL-raising
Side Effects
- abdominal pain
- alopecia
- amblyopia
- amnesia
- angina
- angioedema
- anorexia
- arthralgia
- asthenia
- blurred vision
- bullous rash
- cataracts
- chills
- cholestasis
- cirrhosis
- Co-Enzyme Q-10 deficiency
- confusion
- constipation
- diabetes mellitus
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dyspepsia
- dysphagia
- dyspnea
- edema
- elevated hepatic enzymes
- eosinophilia
- erythema
- erythema multiforme
- fatigue
- fever
- flatulence
- flushing
- headache
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperglycemia
- hyperuricemia
- hypophosphatemia
- hypotension
- immune-mediated necrotizing myopathy
- impotence (erectile dysfunction)
- insomnia
- jaundice
- laryngeal edema
- leukopenia
- lupus-like symptoms
- macular edema
- maculopapular rash
- malaise
- memory impairment
- muscle cramps
- muscle paralysis
- myalgia
- myoglobinuria
- myopathy
- nausea
- ocular irritation
- orthostatic hypotension
- palpitations
- pancreatitis
- peptic ulcer
- peripheral edema
- peripheral neuropathy
- peripheral vasodilation
- photosensitivity
- pruritus
- purpura
- rash
- rhabdomyolysis
- sinus tachycardia
- skin hyperpigmentation
- Stevens-Johnson syndrome
- syncope
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vasculitis
- vesicular rash
- vomiting
- weakness
Monitoring Parameters
- blood glucose
- creatine phosphokinase (CPK)
- LFTs
- serum cholesterol profile
- serum uric acid
Contraindications
- acute myocardial infarction
- alcoholism
- angina
- anticoagulant therapy
- bleeding
- breast-feeding
- children
- cholestasis
- coagulopathy
- contraception requirements
- diabetes mellitus
- driving or operating machinery
- electrolyte imbalance
- endocrine disease
- gallbladder disease
- geriatric
- gout
- hepatic disease
- hepatic encephalopathy
- hepatitis
- hypophosphatemia
- hypotension
- infants
- infection
- jaundice
- myopathy
- orthostatic hypotension
- peptic ulcer disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- rhabdomyolysis
- seizure disorder
- surgery
- thrombocytopenia
- trauma
Lovastatin; niacin (Advicor) is contraindicated in patients with a known hypersensitivity to niacin, lovastatin, or any other product component.
Interactions
- Acarbose
- Acetohexamide
- Albiglutide
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Barbiturates
- Beta-blockers
- Bile acid sequestrants
- Boceprevir
- Bortezomib
- Bosentan
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Carbamazepine
- Central-acting adrenergic agents
- Ceritinib
- Cerivastatin
- Chlorpropamide
- Cilostazol
- Cimetidine
- Clarithromycin
- Cobicistat
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabigatran
- Dabrafenib
- Daclatasvir
- Danazol
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daptomycin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Diltiazem
- Dronedarone
- Dulaglutide
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Encorafenib
- Eplerenone
- Epoprostenol
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Ethanol
- Etravirine
- Everolimus
- Exenatide
- Ezetimibe; Simvastatin
- Fedratinib
- Fenofibrate
- Fenofibric Acid
- Fluconazole
- Fluvastatin
- Fosamprenavir
- Fosphenytoin
- Fostemsavir
- Gemfibrozil
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- grapefruit juice
- Idelalisib
- Iloprost
- Imatinib
- Incretin Mimetics
- Indinavir
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivacaftor
- Ivosidenib
- Ketoconazole
- Lanthanum Carbonate
- Lefamulin
- Leflunomide
- Letermovir
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lixisenatide
- Lomitapide
- Loop diuretics
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mecamylamine
- Mefenamic Acid
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Mifepristone
- Miglitol
- Mitotane
- Nateglinide
- Nefazodone
- Nelfinavir
- Nevirapine
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nicardipine
- Nilotinib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Oxcarbazepine
- Pazopanib
- Perindopril; Amlodipine
- Phenytoin
- Pitavastatin
- Posaconazole
- Potassium-sparing diuretics
- Pramlintide
- Pravastatin
- Protease inhibitors
- Quetiapine
- Quinine
- Raltegravir
- Ranolazine
- Red Yeast Rice
- Repaglinide
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Rosuvastatin
- Saquinavir
- Sarilumab
- Saxagliptin
- Semaglutide
- Siltuximab
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sirolimus
- Sitagliptin
- St. John’s Wort, Hypericum perforatum
- Sulfonylureas
- Tacrolimus
- Telaprevir
- Telbivudine
- Telithromycin
- Teriflunomide
- Tezacaftor; Ivacaftor
- Thiazide diuretics
- Thiazolidinediones
- Ticagrelor
- Tipranavir
- Tocilizumab
- Tolazamide
- Tolbutamide
- Tolvaptan
- Trandolapril; Verapamil
- Treprostinil
- Tucatinib
- Vasodilators
- Verapamil
- Voriconazole
- Warfarin
- Zafirlukast
