Loteprednol Tobramycin

Loteprednol Tobramycin Brand Name– Zylet

What is Loteprednol Tobramycin

Loteprednol Tobramycin (Zylet®) is an ophthalmic suspension containing a combination of a corticosteroid (loteprednol) and an aminoglycoside antibiotic (tobramycin).

It is indicated for the treatment of steroid-responsive inflammatory ocular conditions where superficial bacterial ocular infection or a risk for such infections exists.

Steroid-responsive inflammatory ocular conditions include allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and chronic anterior uveitis resulting from chemical, radiation, or thermal burns or from the penetration of foreign bodies.

Zylet® was approved by the FDA in December 2004.

Indications

  1. Acinetobacter calcoaceticus
  2. acne rosacea
  3. allergic conjunctivitis
  4. bacterial conjunctivitis
  5. cyclitis
  6. Escherichia coli
  7. Haemophilus aegyptius
  8. Haemophilus influenzae (beta-lactamase negative)
  9. Haemophilus influenzae (beta-lactamase positive)
  10. herpes zoster ocular infection
  11. iritis
  12. keratitis
  13. Klebsiella pneumoniae
  14. Moraxella lacunata
  15. Morganella morganii
  16. ocular burns
  17. ophthalmic infection
  18. Proteus mirabilis
  19. Proteus vulgaris
  20. Pseudomonas aeruginosa
  21. Staphylococcus aureus (MRSA)
  22. Staphylococcus aureus (MSSA)
  23. Staphylococcus epidermidis
  24. Streptococcus pneumoniae
  25. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  26. uveitis

Side Effects

  1. blepharitis
  2. cataracts
  3. conjunctivitis
  4. corneal deposits
  5. headache
  6. impaired wound healing
  7. keratitis
  8. ocular discharge
  9. ocular hypertension
  10. ocular infection
  11. ocular irritation
  12. ocular pain
  13. ocular pruritus
  14. photophobia
  15. superinfection
  16. visual impairment

Monitoring Parameters

  • intraocular pressure
  • ophthalmologic exam

Contraindications

  • aminoglycoside hypersensitivity
  • breast-feeding
  • cataracts
  • children
  • contact lenses
  • corneal abrasion
  • corticosteroid hypersensitivity
  • diabetes mellitus
  • fungal infection
  • geriatric
  • glaucoma
  • glycerin hypersensitivity
  • herpes infection
  • herpes simplex keratitis (dendritic keratitis)
  • increased intraocular pressure
  • infants
  • mycobacterial infection
  • neonates
  • ocular infection
  • open-angle glaucoma
  • pregnancy
  • varicella
  • viral infection

Interactions

There are no drug interactions associated with Loteprednol; Tobramycin products.