Loteprednol Tobramycin Brand Name– Zylet
What is Loteprednol Tobramycin
Loteprednol Tobramycin (Zylet®) is an ophthalmic suspension containing a combination of a corticosteroid (loteprednol) and an aminoglycoside antibiotic (tobramycin).
It is indicated for the treatment of steroid-responsive inflammatory ocular conditions where superficial bacterial ocular infection or a risk for such infections exists.
Steroid-responsive inflammatory ocular conditions include allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and chronic anterior uveitis resulting from chemical, radiation, or thermal burns or from the penetration of foreign bodies.
Zylet® was approved by the FDA in December 2004.
Indications
- Acinetobacter calcoaceticus
- acne rosacea
- allergic conjunctivitis
- bacterial conjunctivitis
- cyclitis
- Escherichia coli
- Haemophilus aegyptius
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- herpes zoster ocular infection
- iritis
- keratitis
- Klebsiella pneumoniae
- Moraxella lacunata
- Morganella morganii
- ocular burns
- ophthalmic infection
- Proteus mirabilis
- Proteus vulgaris
- Pseudomonas aeruginosa
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- uveitis
Side Effects
- blepharitis
- cataracts
- conjunctivitis
- corneal deposits
- headache
- impaired wound healing
- keratitis
- ocular discharge
- ocular hypertension
- ocular infection
- ocular irritation
- ocular pain
- ocular pruritus
- photophobia
- superinfection
- visual impairment
Monitoring Parameters
- intraocular pressure
- ophthalmologic exam
Contraindications
- aminoglycoside hypersensitivity
- breast-feeding
- cataracts
- children
- contact lenses
- corneal abrasion
- corticosteroid hypersensitivity
- diabetes mellitus
- fungal infection
- geriatric
- glaucoma
- glycerin hypersensitivity
- herpes infection
- herpes simplex keratitis (dendritic keratitis)
- increased intraocular pressure
- infants
- mycobacterial infection
- neonates
- ocular infection
- open-angle glaucoma
- pregnancy
- varicella
- viral infection
Interactions
There are no drug interactions associated with Loteprednol; Tobramycin products.
