Lisdexamfetamine

Lisdexamfetamine Brand Name– Vyvanse

What is Lisdexamfetamine

Lisdexamfetamine is a prodrug of dextroamphetamine, a centrally acting stimulant indicated for treatment of Attention-Deficit Hyperactivity Disorder (ADHD) in adults and pediatric patients 6 years and older and for treating binge-eating disorder (BED) in adults.

Lisdexamfetamine and other stimulants are considered first-line therapy in the treatment of Attention-Deficit Hyperactivity Disorder (ADHD), and are best utilized as part of a comprehensive approach including psychological, educational, and/or social interventions.

Drug therapy is not intended for use in children with symptoms resulting from environmental factors or other primary psychiatric disorders.

Efficacy for moderate to severe binge-eating disorder (BED) in adults up to 55 years of age was evidenced by the primary outcome of a greater reduction in the reported number of binge-eating days per week versus placebo.

Lisdexamfetamine is not indicated for or recommended for weight loss or the treatment of obesity. Use of other sympathomimetic drugs for weight loss has been associated with serious cardiovascular adverse events.

As with other amphetamines, assess all patients for risk for substance abuse prior to treatment, and monitor treated patients for signs and symptoms of abuse and dependence during therapy.

Lisdexamfetamine was initially FDA-approved in 2007

Indications

• attention-deficit hyperactivity disorder (ADHD)
• binge-eating disorder

For the treatment of attention-deficit hyperactivity disorder (ADHD)

Side Effects

1. abdominal pain
2. agitation
3. alopecia
4. anaphylactoid reactions
5. angioedema
6. anorexia
7. anxiety
8. arrhythmia exacerbation
9. blurred vision
10. bradycardia
11. cardiomyopathy
12. chest pain (unspecified)
13. confusion
14. constipation
15. delirium
16. depression
17. diarrhea
18. diplopia
19. dizziness
20. drowsiness
21. dysgeusia
22. dyskinesia
23. dyspepsia
24. dysphoria
25. dyspnea
26. emotional lability
27. euphoria
28. fatigue
29. fever
30. growth inhibition
31. hallucinations
32. headache
33. hepatitis
34. hostility
35. hyperhidrosis
36. hyperreflexia
37. hypertension
38. hyperthermia
39. hypotension
40. impotence (erectile dysfunction)
41. infection
42. insomnia
43. irritability
44. libido decrease
45. libido increase
46. mania
47. mydriasis
48. myocardial infarction
49. nausea
50. nightmares
51. ocular hypertension
52. palpitations
53. paranoia
54. paresthesias
55. peripheral vasoconstriction
56. photosensitivity
57. physiological dependence
58. priapism
59. pruritus
60. psychological dependence
61. psychosis
62. rash
63. restlessness
64. rhabdomyolysis
65. seizures
66. serotonin syndrome
67. sinus tachycardia
68. skin ulcer
69. Stevens-Johnson syndrome
70. stroke
71. supranormalization
72. syncope
73. tachypnea
74. teeth grinding (bruxism)
75. tolerance
76. Tourette’s syndrome
77. toxic epidermal necrolysis
78. tremor
79. urticaria
80. visual impairment
81. vomiting
82. weight loss
83. withdrawal
84. xerostomia

Monitoring Parameters

• blood pressure
• growth rate
• heart rate
• serum creatinine/BUN
• weight

Contraindications

• abrupt discontinuation
• acute myocardial infarction
• alcoholism
• anorexia nervosa
• aortic stenosis
• arteriosclerosis
• bipolar disorder
• breast-feeding
• bulimia nervosa
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• congenital heart disease
• coronary artery disease
• depression
• driving or operating machinery
• geriatric
• glaucoma
• growth inhibition
• heart failure
• hepatic disease
• hypercortisolism
• hypertension
• hyperthyroidism
• infants
• labor
• mania
• MAOI therapy
• myocardial infarction
• neonates
• obesity treatment
• obstetric delivery
• peripheral vascular disease
• pregnancy
• premature labor
• priapism
• prosthetic heart valves
• psychosis
• radiographic contrast administration
• Raynaud’s phenomenon
• renal failure
• renal impairment
• schizophrenia
• seizure disorder
• seizures
• stroke
• substance abuse
• suicidal ideation
• surgery
• syncope
• tachycardia
• thyrotoxicosis
• tics
• Tourette’s syndrome
• valvular heart disease
• ventricular arrhythmias
• ventricular dysfunction
• visual disturbance

Interactions

• Acarbose
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• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
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