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Levofloxacin Brand Names
Iquix | Levaquin | Levaquin Leva-Pak | Quixin
What is Levofloxacin
Levofloxacin is a quinolone antibiotic available for oral, intravenous, or ophthalmic administration.
It is the optically active L-isomer of ofloxacin. Plasma concentrations are similar after intravenous or oral administration and these routes can be considered interchangeable. Unlike ciprofloxacin, levofloxacin does not interact significantly with theophylline.
Levofloxacin is FDA-approved for the treatment of bacterial conjunctivitis, community-acquired pneumonia (including cases caused by multi-drug-resistant strains of S. pneumoniae), nosocomial pneumonia, skin and skin structure infections, complicated urinary tract infections (UTIs), acute pyelonephritis, chronic bacterial prostatitis, inhalation anthrax (post-exposure), and plague.
Levofloxacin is also FDA-approved for sinusitis, chronic bronchitis, and uncomplicated UTIs; however, due to the potential for serious adverse events, quinolones should only be used for these infection types when alternative treatment options cannot be used.
Disabling and potentially irreversible serious adverse reactions associated with quinolones include tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects.
Other significant adverse reactions include potential QT prolongation and myasthenia gravis exacerbation.
Indications
- Acinetobacter baumannii
- Acinetobacter lwoffii
- anthrax
- anthrax prophylaxis
- Bacillus anthracis
- bacterial conjunctivitis
- bacterial infection prophylaxis
- Bordetella pertussis
- bronchitis
- Campylobacter jejuni
- Campylobacter sp.
- campylobacteriosis
- cellulitis
- cervicitis
- chlamydia infection
- Chlamydophila pneumoniae
- Citrobacter freundii
- Citrobacter koseri
- Clostridium perfringens
- community-acquired pneumonia
- diabetic foot ulcer
- Enterobacter cloacae
- Enterobacter sakazakii
- Enterococcus faecalis
- epididymitis
- Escherichia coli
- febrile neutropenia
- furunculosis
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Helicobacter pylori
- Helicobacter pylori (H. pylori) eradication
- impetigo
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Legionella pneumophila
- Moraxella catarrhalis
- Morganella morganii
- Mycobacterium avium complex infection
- Mycobacterium tuberculosis
- Mycoplasma pneumoniae
- non-gonococcal urethritis (NGU)
- nosocomial pneumonia
- Pantoea agglomerans
- pelvic inflammatory disease (PID)
- plague
- plague prophylaxis
- pneumonia
- prostatitis
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Providencia stuartii
- Pseudomonas aeruginosa
- Pseudomonas fluorescens
- pyelonephritis
- pyoderma
- Salmonella sp.
- Salmonella typhi
- salmonellosis
- sepsis
- Serratia marcescens
- Shigella dysenteriae
- Shigella sp.
- shigellosis
- sinusitis
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Staphylococcus haemolyticus
- Staphylococcus saprophyticus
- Streptococcus agalactiae (group B streptococci)
- Streptococcus milleri
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp.
- surgical infection prophylaxis
- traveler’s diarrhea
- tuberculosis infection
- typhoid fever
- urethritis
- urinary tract infection (UTI)
- Viridans streptococci
- Yersinia pestis
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- anosmia
- anxiety
- aortic dissection
- aplastic anemia
- arthralgia
- blurred vision
- bronchospasm
- candidiasis
- cardiac arrest
- chest pain (unspecified)
- coma
- confusion
- constipation
- crystalluria
- cylindruria
- delirium
- depression
- diarrhea
- diplopia
- dizziness
- dysesthesia
- dysgeusia
- dyspepsia
- dysphonia
- dyspnea
- edema
- elevated hepatic enzymes
- encephalopathy
- eosinophilia
- epistaxis
- erythema multiforme
- esophagitis
- fever
- foreign body sensation
- gastritis
- glossitis
- hallucinations
- headache
- headache
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperglycemia
- hyperkalemia
- hyperkinesis
- hypertonia
- hypoesthesia
- hypoglycemia
- hypotension
- increased intracranial pressure
- injection site reaction
- insomnia
- interstitial nephritis
- jaundice
- laryngeal edema
- leukopenia
- memory impairment
- musculoskeletal pain
- myalgia
- myasthenia gravis
- nausea
- neurotoxicity
- nightmares
- ocular irritation
- ocular pain
- ocular pruritus
- palpitations
- pancreatitis
- pancytopenia
- paranoia
- paresthesias
- parosmia
- peripheral neuropathy
- peripheral vasodilation
- pharyngitis
- phlebitis
- photophobia
- photosensitivity
- pneumonitis
- prolonged bleeding time
- pruritus
- pseudomembranous colitis
- pseudotumor cerebri
- psychosis
- QT prolongation
- rash
- renal failure (unspecified)
- restlessness
- rhabdomyolysis
- scotomata
- seizures
- serum sickness
- Stevens-Johnson syndrome
- stomatitis
- suicidal ideation
- syncope
- tendinitis
- tendon rupture
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- tinnitus
- torsade de pointes
- toxic epidermal necrolysis
- tremor
- urticaria
- uveitis
- vaginitis
- vasculitis
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weakness
- xerophthalmia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- aneurysm
- aortic dissection
- apheresis
- arteriosclerosis
- atrial fibrillation
- AV block
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiomyopathy
- celiac disease
- cerebrovascular disease
- children
- colitis
- contact lenses
- corticosteroid therapy
- dehydration
- depression
- diabetes mellitus
- diarrhea
- driving or operating machinery
- females
- fever
- geriatric
- GI disease
- heart failure
- hepatic disease
- hepatitis
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infants
- inflammatory bowel disease
- jaundice
- laboratory test interference
- long QT syndrome
- myasthenia gravis
- myocardial infarction
- neonates
- neurotoxicity
- organ transplant
- peripheral neuropathy
- pheochromocytoma
- pregnancy
- pseudomembranous colitis
- psychiatric event
- QT prolongation
- quinolone hypersensitivity
- renal failure
- renal impairment
- rheumatoid arthritis
- seizure disorder
- sexually transmitted disease
- sickle cell disease
- sleep deprivation
- stroke
- sunlight (UV) exposure
- systemic lupus erythematosus (SLE)
- tendinitis
- tendinopathy
- tendon pain
- tendon rupture
- torsade de pointes
- ulcerative colitis
Interactions
- Abarelix
- Acarbose
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetohexamide
- Albiglutide
- Alfuzosin
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Celecoxib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apomorphine
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atomoxetine
- Azithromycin
- Bedaquiline
- Bepridil
- Betamethasone
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Budesonide
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Canagliflozin
- Canagliflozin; Metformin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Celecoxib
- Ceritinib
- Chloroquine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Choline Salicylate; Magnesium Salicylate
- Chromium
- Cisapride
- Citalopram
- Clarithromycin
- Class IA Antiarrhythmics
- Clindamycin; Tretinoin
- Clofazimine
- Clomipramine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Cortisone
- Crizotinib
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dasatinib
- Deflazacort
- Degarelix
- Desipramine
- Deutetrabenazine
- Dexamethasone
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diclofenac
- Diclofenac; Misoprostol
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Diflunisal
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Dronedarone
- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Eliglustat
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- enteral feedings
- Entrectinib
- Eribulin
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esomeprazole; Naproxen
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Exenatide
- Ezogabine
- Famotidine; Ibuprofen
- Fenoprofen
- Fingolimod
- Flecainide
- Fluconazole
- Fludrocortisone
- Fluocinolone; Hydroquinone; Tretinoin
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurbiprofen
- Fluvoxamine
- Foscarnet
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Goserelin
- Granisetron
- Halobetasol; Tazarotene
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Hetastarch; Dextrose; Electrolytes
- Histrelin
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Hydroxychloroquine
- Hydroxyzine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Ibutilide
- Iloperidone
- Imipramine
- Incretin Mimetics
- Indomethacin
- Inotuzumab Ozogamicin
- Insulin Aspart
- Insulin Aspart; Insulin Aspart Protamine
- Insulin Degludec
- Insulin Degludec; Liraglutide
- Insulin Detemir
- Insulin Glargine
- Insulin Glargine; Lixisenatide
- Insulin Glulisine
- Insulin Lispro
- Insulin Lispro; Insulin Lispro Protamine
- Insulin, Inhaled
- Insulins
- Iron
- Iron Salts
- Isophane Insulin (NPH)
- Itraconazole
- Ivosidenib
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Lapatinib
- Lefamulin
- Lente Insulin
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levonorgestrel
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lithium
- Lixisenatide
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Macimorelin
- Magnesium
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salicylate
- Maprotiline
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meglitinides
- Meloxicam
- Meperidine; Promethazine
- Mequinol; Tretinoin
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methylprednisolone
- Metronidazole
- Midostaurin
- Mifepristone
- Miglitol
- Mirtazapine
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nilotinib
- Nonsteroidal antiinflammatory drugs
- Norethindrone
- Norgestrel
- Nortriptyline
- Octreotide
- Olanzapine
- Ondansetron
- Oral Contraceptives
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Ozanimod
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pioglitazone
- Piroxicam
- Pitolisant
- Polycarbophil
- Polysaccharide-Iron Complex
- Porfimer
- Posaconazole
- Pramlintide
- Prednisolone
- Prednisone
- Primaquine
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinapril
- Quinidine
- Quinine
- Ranolazine
- Regular Insulin
- Regular Insulin; Isophane Insulin (NPH)
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Rofecoxib
- Romidepsin
- Rosiglitazone
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Semaglutide
- Sertraline
- Sevelamer
- SGLT2 Inhibitors
- Short-acting beta-agonists
- Simvastatin; Sitagliptin
- Siponimod
- Sitagliptin
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Sorafenib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sucralfate
- Sulfonylureas
- Sulindac
- Sunitinib
- Tacrolimus
- Tamoxifen
- Tazarotene
- Telavancin
- Telithromycin
- Tetrabenazine
- Thiazolidinediones
- Thioridazine
- Tolazamide
- Tolbutamide
- Tolmetin
- Tolterodine
- Toremifene
- Trazodone
- Tretinoin, ATRA
- Triamcinolone
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Ultralente Insulin
- Valdecoxib
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Verteporfin
- Voriconazole
- Vorinostat
- Warfarin
- Zinc
- Zinc Salts
- Ziprasidone