Leuprolide

Leuprolide Brand Names

Eligard | Fensolv | Lupron | Lupron Depot | Lupron Depot-Ped | Viadur

What is Leuprolide

Leuprolide is a synthetic analog of naturally occurring gonadotropin-releasing hormone (GnRH).

Leuprolide is similar in activity and indications to goserelin. Leuprolide is used as a hormonal antagonist in the treatment of advanced prostatic cancer, and as hormonal therapy in the treatment of endometriosis and uterine fibroids.

Leuprolide injection is designated as an orphan drug for the treatment of precocious puberty.

Lupron Depot-Ped, a prefilled dual-chamber syringe that delivers leuprolide acetate over 1 to 3 months, is indicated for the treatment of children with central precocious puberty.

Fensolvi is a sterile polymeric matrix formulation of leuprolide acetate, administered by subcutaneous injection, that is indicated for the treatment of children with central precocious puberty. It delivers the drug at a controlled rate over 6 months.

Eligard is a sterile polymeric matrix formulation of leuprolide acetate, administered by subcutaneous injection, that delivers the drug at a controlled rate over a specific time period.

Three formulations of Eligard have been approved by the FDA for the palliative treatment of advanced prostate cancer that deliver leuprolide acetate over 1 to 6 months.

Indications

1. benign prostatic hyperplasia (BPH)
2. breast cancer
3. endometriosis
4. fertility preservation
5. infertility
6. precocious puberty
7. premenstrual syndrome (PMS)
8. prostate cancer
9. stuttering priapism
10. uterine leiomyomata

For the treatment of benign prostatic hyperplasia (BPH)

Side Effects

1. abdominal pain
2. acneiform rash
3. agitation
4. alopecia
5. amblyopia
6. amenorrhea
7. amnesia
8. anaphylactoid reactions
9. anemia
10. angina
11. anorexia
12. anxiety
13. appetite stimulation
14. arrhythmia exacerbation
15. arthralgia
16. asthenia
17. atrial fibrillation
18. back pain
19. bladder spasm
20. blurred vision
21. bone fractures
22. bone pain
23. bradycardia
24. breast enlargement
25. chills
26. colitis
27. confusion
28. constipation
29. cough
30. dehydration
31. depression
32. diabetes mellitus
33. diarrhea
34. dizziness
35. dysgeusia
36. dysmenorrhea
37. dyspepsia
38. dysphagia
39. dysphonia
40. dyspnea
41. dysuria
42. ecchymosis
43. edema
44. elevated hepatic enzymes
45. emotional lability
46. eosinophilia
47. epididymitis
48. epistaxis
49. eructation
50. erythema
51. erythema multiforme
52. euphoria
53. fatigue
54. feminization
55. fever
56. flatulence
57. GI bleeding
58. GI obstruction
59. gingivitis
60. goiter
61. growth inhibition
62. gynecomastia
63. hallucinations
64. headache
65. hearing loss
66. heart failure
67. hematoma
68. hematuria
69. hemoptysis
70. hepatitis
71. hepatomegaly
72. hiccups
73. hot flashes
74. hyperesthesia
75. hyperglycemia
76. hyperhidrosis
77. hyperlipidemia
78. hyperphosphatemia
79. hyperreflexia
80. hypertension
81. hyperuricemia
82. hypokalemia
83. hyporeflexia
84. hypotension
85. hypoxia
86. impaired wound healing
87. impotence (erectile dysfunction)
88. increased urinary frequency
89. infection
90. influenza
91. injection site reaction
92. insomnia
93. lethargy
94. leukopenia
95. libido decrease
96. libido increase
97. lymphadenopathy
98. malaise
99. mastalgia
100. melasma
101. memory impairment
102. muscle cramps
103. muscle paralysis
104. musculoskeletal pain
105. myalgia
106. myocardial infarction
107. myopathy
108. nasal congestion
109. nausea
110. nephrolithiasis
111. new primary malignancy
112. night sweats
113. nocturia
114. osteopenia
115. osteoporosis
116. ovarian enlargement
117. ovarian hyperstimulation syndrome (OHSS)
118. palpitations
119. paresthesias
120. parosmia
121. peptic ulcer
122. peripheral edema
123. peripheral neuropathy
124. pharyngitis
125. phlebitis
126. photosensitivity
127. pituitary apoplexy
128. pleural effusion
129. prostate pain
130. ptosis
131. pulmonary edema
132. pulmonary embolism
133. pulmonary fibrosis
134. purpura
135. pyuria
136. QT prolongation
137. rash
138. rectal fistula
139. renal tubular obstruction
140. rhinitis
141. rhinorrhea
142. seborrhea
143. seizures
144. sinus tachycardia
145. sinusitis
146. skin hyperpigmentation
147. skin hypopigmentation
148. skin irritation
149. skin ulcer
150. stroke
151. suicidal ideation
152. syncope
153. synovitis
154. testicular atrophy
155. testicular pain
156. thrombocytopenia
157. thromboembolism
158. thrombosis
159. tinnitus
160. tremor
161. urinary incontinence
162. urinary retention
163. urinary urgency
164. urticaria
165. vaginal bleeding
166. vaginal discharge
167. vaginitis
168. vertigo
169. visual impairment
170. vomiting
171. weakness
172. weight gain
173. weight loss
174. wheezing
175. xerophthalmia
176. xerosis
177. xerostomia

Monitoring Parameters

• blood glucose
• blood pressure
• glycosylated hemoglobin A1c (HbA1c)
• prostate-specific antigen (PSA)
• serum gonadotropin concentrations
• serum testosterone concentrations

Contraindications

• apheresis
• AV block
• benzyl alcohol hypersensitivity
• bradycardia
• brain tumor
• breast-feeding
• cardiac disease
• cardiomyopathy
• celiac disease
• cerebrovascular disease
• children
• contraception requirements
• depression
• diabetes mellitus
• dysfunctional uterine bleeding
• females
• fever
• geriatric
• Gonadotropin-Releasing Hormone (GnRH) analogs hypersensitivity
• heart failure
• human immunodeficiency virus (HIV) infection
• hypercholesterolemia
• hyperglycemia
• hyperparathyroidism
• hypertension
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypothermia
• hypothyroidism
• long QT syndrome
• menstruation
• myocardial infarction
• obesity
• osteopenia
• osteoporosis
• pheochromocytoma
• pituitary insufficiency
• pregnancy
• pregnancy testing
• QT prolongation
• renal impairment
• rheumatoid arthritis
• seizure disorder
• sickle cell disease
• sleep deprivation
• spinal cord compression
• stroke
• suicidal ideation
• systemic lupus erythematosus (SLE)
• tobacco smoking
• urinary tract obstruction
• vaginal bleeding

Interactions

• Aclidinium; Formoterol
• Albuterol
• Albuterol; Ipratropium
• Alfuzosin
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amoxapine
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• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
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• Aripiprazole
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• Artemether; Lumefantrine
• Asenapine
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• Bedaquiline
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Brexpiprazole
• Budesonide; Formoterol
• Buprenorphine
• Buprenorphine; Naloxone
• Cariprazine
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• Clofazimine
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• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Crizotinib
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• Desflurane
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• Deutetrabenazine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Disopyramide
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• Donepezil
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• Doxepin
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• Formoterol; Mometasone
• Foscarnet
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• Granisetron
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• Indacaterol
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• Lithium
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• Loperamide; Simethicone
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• Pimavanserin
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• Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
• Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
• Primaquine
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• Propafenone
• Protriptyline
• Quetiapine
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• Trazodone
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