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Lapatinib Brand Name
What is Lapatinib
Lapatinib is a 4-anilinoquinazoline kinase inhibitor, targeted against the intracellular tyrosine kinase domains of primarily HER2, and to a lesser extent EGFR.
It is indicated for the treatment of metastatic breast cancer in combination with capecitabine in pre- and postmenopausal patients who have had disease progression on trastuzumab and have previously received treatment with an anthracycline and a taxane; it is also indicated in postmenopausal women in combination with letrozole.
Hepatotoxicity, which may be severe, has been observed in clinical trials and postmarketing experience; monitor liver function tests.
Additionally, decreases in left ventricular ejection fraction and QT prolongation have occurred in some patients treated with lapatinib; monitor patients appropriately for these adverse reactions.
Indications
- breast cancer
For the treatment of breast cancer
for the treatment of postmenopausal women with hormone receptor (HR)-positive, HER2-positive metastatic breast cancer, in combination with letrozole
Side Effects
- alopecia
- alopecia
- anemia
- anorexia
- anorexia
- arthralgia
- arthralgia
- asthenia
- asthenia
- back pain
- back pain
- cough
- diarrhea
- diarrhea
- dyspepsia
- dyspepsia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- epistaxis
- erythema multiforme
- fatigue
- fatigue
- headache
- headache
- heart failure
- heart failure
- hepatotoxicity
- hyperbilirubinemia
- hyperbilirubinemia
- insomnia
- insomnia
- nausea
- nausea
- neutropenia
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- pneumonitis
- pruritus
- pruritus
- QT prolongation
- rash
- rash
- serious hypersensitivity reactions or anaphylaxis
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- thrombocytopenia
- torsade de pointes
- toxic epidermal necrolysis
- vomiting
- vomiting
- xerosis
- xerosis
Monitoring Parameters
- ECG
- ejection fraction
- LFTs
- pregnancy testing
- serum magnesium
- serum potassium
Contraindications
- apheresis
- AV block
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- contraception requirements
- diarrhea
- females
- fever
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infertility
- long QT syndrome
- male-mediated teratogenicity
- myocardial infarction
- pheochromocytoma
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- QT prolongation
- reproductive risk
- rheumatoid arthritis
- serious rash
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- torsade de pointes
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Afatinib
- Alfentanil
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apalutamide
- Apomorphine
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Betrixaban
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Cabozantinib
- Caffeine; Ergotamine
- Capmatinib
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Ceritinib
- Chloramphenicol
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabigatran
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Deutetrabenazine
- Dexamethasone
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxepin
- Doxorubicin
- Dronabinol
- Dronedarone
- Droperidol
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Enflurane
- Entrectinib
- Enzalutamide
- Ergotamine
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Eszopiclone
- Etravirine
- Everolimus
- Ezogabine
- Felodipine
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluvoxamine
- food
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Fostamatinib
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride; Rosiglitazone
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyzine
- Ibrutinib
- Ibuprofen; Oxycodone
- Ibutilide
- Idelalisib
- Iloperidone
- Imipramine
- Indinavir
- Inotuzumab Ozogamicin
- Isavuconazonium
- Isoflurane
- Isradipine
- Istradefylline
- Itraconazole
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Lamivudine; Tenofovir Disoproxil Fumarate
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levofloxacin
- Lidocaine
- Lidocaine; Prilocaine
- Lithium
- Lofexidine
- Lomitapide
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Macimorelin
- Maprotiline
- Maraviroc
- Mefloquine
- Meperidine; Promethazine
- Metformin; Rosiglitazone
- Methadone
- Metronidazole
- Midazolam
- Midostaurin
- Mifepristone
- Mirtazapine
- Mitotane
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Naldemedine
- Nanoparticle Albumin-Bound Paclitaxel
- Nefazodone
- Nelfinavir
- Neratinib
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxycodone
- Ozanimod
- Paclitaxel
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pitolisant
- Ponatinib
- Posaconazole
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifamycins
- Rifaximin
- Rilpivirine
- Rimegepant
- Risperidone
- Ritonavir
- Rolapitant
- Romidepsin
- Rosiglitazone
- Sapropterin
- Saquinavir
- Sarecycline
- Selexipag
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Simeprevir
- Siponimod
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Sorafenib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sunitinib
- Tacrolimus
- Talazoparib
- Tamoxifen
- Telavancin
- Telithromycin
- Temsirolimus
- Tenofovir, PMPA
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Thioridazine
- Ticagrelor
- Tipranavir
- Tolterodine
- Topotecan
- Toremifene
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Tucatinib
- Ubrogepant
- Vandetanib
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Verapamil
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Voriconazole
- Vorinostat
- Ziprasidone
- Zonisamide