Lapatinib

Lapatinib Brand Name

What is Lapatinib

Lapatinib is a 4-anilinoquinazoline kinase inhibitor, targeted against the intracellular tyrosine kinase domains of primarily HER2, and to a lesser extent EGFR.

It is indicated for the treatment of metastatic breast cancer in combination with capecitabine in pre- and postmenopausal patients who have had disease progression on trastuzumab and have previously received treatment with an anthracycline and a taxane; it is also indicated in postmenopausal women in combination with letrozole.

Hepatotoxicity, which may be severe, has been observed in clinical trials and postmarketing experience; monitor liver function tests.

Additionally, decreases in left ventricular ejection fraction and QT prolongation have occurred in some patients treated with lapatinib; monitor patients appropriately for these adverse reactions.

Indications

  • breast cancer

For the treatment of breast cancer

for the treatment of postmenopausal women with hormone receptor (HR)-positive, HER2-positive metastatic breast cancer, in combination with letrozole

Side Effects

  1. alopecia
  2. alopecia
  3. anemia
  4. anorexia
  5. anorexia
  6. arthralgia
  7. arthralgia
  8. asthenia
  9. asthenia
  10. back pain
  11. back pain
  12. cough
  13. diarrhea
  14. diarrhea
  15. dyspepsia
  16. dyspepsia
  17. dyspnea
  18. dyspnea
  19. elevated hepatic enzymes
  20. elevated hepatic enzymes
  21. epistaxis
  22. epistaxis
  23. erythema multiforme
  24. fatigue
  25. fatigue
  26. headache
  27. headache
  28. heart failure
  29. heart failure
  30. hepatotoxicity
  31. hyperbilirubinemia
  32. hyperbilirubinemia
  33. insomnia
  34. insomnia
  35. nausea
  36. nausea
  37. neutropenia
  38. palmar-plantar erythrodysesthesia (hand and foot syndrome)
  39. palmar-plantar erythrodysesthesia (hand and foot syndrome)
  40. pneumonitis
  41. pruritus
  42. pruritus
  43. QT prolongation
  44. rash
  45. rash
  46. serious hypersensitivity reactions or anaphylaxis
  47. Stevens-Johnson syndrome
  48. stomatitis
  49. stomatitis
  50. thrombocytopenia
  51. torsade de pointes
  52. toxic epidermal necrolysis
  53. vomiting
  54. vomiting
  55. xerosis
  56. xerosis

Monitoring Parameters

  • ECG
  • ejection fraction
  • LFTs
  • pregnancy testing
  • serum magnesium
  • serum potassium

Contraindications

  • apheresis
  • AV block
  • bradycardia
  • breast-feeding
  • cardiomyopathy
  • celiac disease
  • contraception requirements
  • diarrhea
  • females
  • fever
  • geriatric
  • heart failure
  • hepatic disease
  • hepatotoxicity
  • human immunodeficiency virus (HIV) infection
  • hyperparathyroidism
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypothermia
  • hypothyroidism
  • infertility
  • long QT syndrome
  • male-mediated teratogenicity
  • myocardial infarction
  • pheochromocytoma
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • pulmonary disease
  • QT prolongation
  • reproductive risk
  • rheumatoid arthritis
  • serious rash
  • sickle cell disease
  • sleep deprivation
  • stroke
  • systemic lupus erythematosus (SLE)
  • torsade de pointes

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Afatinib
  • Alfentanil
  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anagrelide
  • Apalutamide
  • Apomorphine
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azithromycin
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzhydrocodone; Acetaminophen
  • Betrixaban
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Cabozantinib
  • Caffeine; Ergotamine
  • Capmatinib
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Ceritinib
  • Chloramphenicol
  • Chloroquine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clomipramine
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Dabigatran
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Degarelix
  • Delavirdine
  • Desflurane
  • Desipramine
  • Deutetrabenazine
  • Dexamethasone
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxepin
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
  • Eltrombopag
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Enzalutamide
  • Ergotamine
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Eszopiclone
  • Etravirine
  • Everolimus
  • Ezogabine
  • Felodipine
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluvoxamine
  • food
  • Fosamprenavir
  • Foscarnet
  • Fosphenytoin
  • Fostamatinib
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gilteritinib
  • Glasdegib
  • Glecaprevir; Pibrentasvir
  • Glimepiride; Rosiglitazone
  • Goserelin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibrutinib
  • Ibuprofen; Oxycodone
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imipramine
  • Indinavir
  • Inotuzumab Ozogamicin
  • Isavuconazonium
  • Isoflurane
  • Isradipine
  • Istradefylline
  • Itraconazole
  • Ivacaftor
  • Ivosidenib
  • Ixabepilone
  • Ketoconazole
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Ledipasvir; Sofosbuvir
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levofloxacin
  • Lidocaine
  • Lidocaine; Prilocaine
  • Lithium
  • Lofexidine
  • Lomitapide
  • Long-acting beta-agonists
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Macimorelin
  • Maprotiline
  • Maraviroc
  • Mefloquine
  • Meperidine; Promethazine
  • Metformin; Rosiglitazone
  • Methadone
  • Metronidazole
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Mirtazapine
  • Mitotane
  • Morphine
  • Morphine; Naltrexone
  • Moxifloxacin
  • Naldemedine
  • Nanoparticle Albumin-Bound Paclitaxel
  • Nefazodone
  • Nelfinavir
  • Neratinib
  • Nilotinib
  • Nimodipine
  • Nintedanib
  • Nisoldipine
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxycodone
  • Ozanimod
  • Paclitaxel
  • Paliperidone
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pitolisant
  • Ponatinib
  • Posaconazole
  • Primaquine
  • Primidone
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifamycins
  • Rifaximin
  • Rilpivirine
  • Rimegepant
  • Risperidone
  • Ritonavir
  • Rolapitant
  • Romidepsin
  • Rosiglitazone
  • Sapropterin
  • Saquinavir
  • Sarecycline
  • Selexipag
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • Short-acting beta-agonists
  • Simeprevir
  • Siponimod
  • Sirolimus
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sunitinib
  • Tacrolimus
  • Talazoparib
  • Tamoxifen
  • Telavancin
  • Telithromycin
  • Temsirolimus
  • Tenofovir, PMPA
  • Tetrabenazine
  • Tezacaftor; Ivacaftor
  • Thioridazine
  • Ticagrelor
  • Tipranavir
  • Tolterodine
  • Topotecan
  • Toremifene
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Triclabendazole
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Triptorelin
  • Tucatinib
  • Ubrogepant
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine
  • Voriconazole
  • Vorinostat
  • Ziprasidone
  • Zonisamide
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