Lansoprazole

Lansoprazole Brand Names

First-Lansoprazole | Heartburn Relief | Prevacid

What is Lansoprazole

Lansoprazole is an acid proton-pump inhibitor (PPI). It is used for the short-term treatment of duodenal or gastric ulcers, gastroesophageal reflux disease (GERD), and erosive esophagitis.

It is also indicated to maintain healing of duodenal ulcer and esophagitis, for NSAID-induced ulcer treatment or prophylaxis, for long-term treatment of Zollinger-Ellison syndrome (pathological hypersecretory condition), and for use in combination with antibiotics in the eradication of Helicobacter pylori (H. pylori) to reduce the risk of duodenal ulcer recurrence.

Clinicians should test for H. pylori infection in patients presenting with non-ulcer dyspepsia; patients found to be H. pylori positive should be started on combination eradication therapy.

Eradication of H. pylori offers modest, but significant, symptom relief in non-ulcer dyspepsia and reduces the risk of developing peptic ulcer disease, atrophic gastritis, and gastric cancer.

For populations with a low prevalence of H. pylori infection (less than 10%), starting a 2 to 4 week empiric trial of a PPI is an alternate approach.

Clinically, lansoprazole is at least as effective as omeprazole in treating peptic ulcers and reflux esophagitis, and it has been shown to relieve reflux symptoms more quickly than either omeprazole or ranitidine.

Over a 4-week period, ulcer healing was greater with lansoprazole than ranitidine or placebo in a double-blind study of the treatment of active duodenal ulcer.

A comparative study of omeprazole and lansoprazole in the short-term treatment of reflux esophagitis showed no significant difference in healing after 4 or 8 weeks.

Lansoprazole, however, showed greater improvement in heartburn and acid regurgitation symptoms after 4 weeks.

On the basis of available research, no clear advantage has been demonstrated for the use of 1 PPI over another in the treatment of GERD. Instead, a key to optimizing effectiveness is tailoring dosage timing and considering twice daily dosing; traditional delayed release PPIs should be administered 30 to 60 minutes before a meal for maximal pH control.

A one-time switch to a different PPI in a refractory patient may be useful.

PPIs have been associated with an increased risk of Clostridium difficile-associated diarrhea.

Indications

1. duodenal ulcer
2. dyspepsia
3. eosinophilic esophagitis
4. esophagitis
5. gastric ulcer
6. gastroesophageal reflux disease (GERD)
7. Helicobacter pylori (H. pylori) eradication
8. NSAID-induced ulcer prophylaxis
9. pyrosis (heartburn)
10. stress gastritis prophylaxis
11. Zollinger-Ellison syndrome

Side Effects

1. abdominal pain
2. acne vulgaris
3. agitation
4. agranulocytosis
5. alopecia
6. amblyopia
7. amnesia
8. anaphylactoid reactions
9. anemia
10. angina
11. anorexia
12. anxiety
13. aplastic anemia
14. appetite stimulation
15. arrhythmia exacerbation
16. arthralgia
17. asthenia
18. back pain
19. bezoar
20. blepharitis
21. blurred vision
22. bone fractures
23. bradycardia
24. breast enlargement
25. bronchospasm
26. candidiasis
27. cataracts
28. chest pain (unspecified)
29. chills
30. cholelithiasis
31. colitis
32. confusion
33. conjunctivitis
34. constipation
35. contact dermatitis
36. cough
37. dehydration
38. depression
39. diabetes mellitus
40. diaphoresis
41. diarrhea
42. diplopia
43. dizziness
44. drowsiness
45. dysgeusia
46. dysmenorrhea
47. dyspepsia
48. dysphagia
49. dyspnea
50. dysuria
51. edema
52. elevated hepatic enzymes
53. emotional lability
54. eosinophilia
55. epistaxis
56. eructation
57. erythema multiforme
58. esophageal ulceration
59. esophagitis
60. fatigue
61. fever
62. flatulence
63. gastric polyps
64. gastritis
65. GI bleeding
66. glossitis
67. glycosuria
68. goiter
69. gout
70. gynecomastia
71. halitosis
72. hallucinations
73. headache
74. hearing loss
75. hematemesis
76. hematuria
77. hemolysis
78. hemolytic anemia
79. hemoptysis
80. hiccups
81. hoarseness
82. hostility
83. hyperbilirubinemia
84. hyperglycemia
85. hyperkalemia
86. hyperkinesis
87. hyperlipidemia
88. hypersalivation
89. hypertension
90. hypertonia
91. hyperuricemia
92. hypoesthesia
93. hypoglycemia
94. hypomagnesemia
95. hypotension
96. hypothyroidism
97. impotence (erectile dysfunction)
98. increased urinary frequency
99. infection
100. injection site reaction
101. insomnia
102. interstitial nephritis
103. leukopenia
104. leukorrhea
105. libido decrease
106. libido increase
107. lupus-like symptoms
108. lymphadenopathy
109. maculopapular rash
110. malaise
111. mastalgia
112. melena
113. menorrhagia
114. menstrual irregularity
115. migraine
116. muscle cramps
117. musculoskeletal pain
118. myalgia
119. myasthenia
120. myocardial infarction
121. nausea
122. neutropenia
123. ocular pain
124. palpitations
125. pancreatitis
126. pancytopenia
127. paresthesias
128. parosmia
129. pelvic pain
130. peripheral edema
131. pernicious anemia
132. pharyngitis
133. photophobia
134. polyuria
135. pruritus
136. pseudomembranous colitis
137. ptosis
138. rash
139. rhinitis
140. seizures
141. sinus tachycardia
142. sinusitis
143. Stevens-Johnson syndrome
144. stomatitis
145. stool discoloration
146. stroke
147. syncope
148. synovitis
149. tenesmus
150. thrombocytopenia
151. thrombotic thrombocytopenic purpura (TTP)
152. tinnitus
153. toxic epidermal necrolysis
154. tremor
155. urethral pain
156. urinary retention
157. urticaria
158. vaginitis
159. vertigo
160. vitamin B12 deficiency
161. vomiting
162. weight gain
163. weight loss
164. xerophthalmia
165. xerosis
166. xerostomia

Monitoring Parameters

• LFTs
• serum magnesium

Contraindications

• bone fractures
• breast-feeding
• diarrhea
• gastric cancer
• geriatric
• hepatic disease
• hypomagnesemia
• infants
• laboratory test interference
• long QT syndrome
• neonates
• osteopenia
• osteoporosis
• phenylketonuria
• pregnancy
• proton pump inhibitors (PPIs) hypersensitivity
• pseudomembranous colitis
• rebound acid hypersecretion
• systemic lupus erythematosus (SLE)
• vitamin B12 deficiency

Interactions

• Acalabrutinib
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Alendronate
• Alendronate; Cholecalciferol
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amobarbital
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Ampicillin
• Ampicillin; Sulbactam
• Anticholinergics
• Apalutamide
• Aprepitant, Fosaprepitant
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol; Chlorthalidone
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azilsartan; Chlorthalidone
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benztropine
• Bisacodyl
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Bosentan
• Bosutinib
• Budesonide
• Budesonide; Formoterol
• Bumetanide
• Butabarbital
• Calcium Carbonate; Risedronate
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capecitabine
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Cefpodoxime
• Ceftibuten
• Cefuroxime
• Chlordiazepoxide; Clidinium
• Chlorothiazide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Citalopram
• Clobazam
• Cobicistat
• Conivaptan
• Cyanocobalamin, Vitamin B12
• Cysteamine
• Dacomitinib
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Dasatinib
• Delavirdine
• Dexamethasone
• Dexmethylphenidate
• Dextroamphetamine
• Dicyclomine
• Digoxin
• Dolutegravir; Rilpivirine
• Dronedarone
• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril; Hydrochlorothiazide, HCTZ
• Enzalutamide
• Eprosartan; Hydrochlorothiazide, HCTZ
• Erlotinib
• Escitalopram
• Eslicarbazepine
• Ethacrynic Acid
• Fenofibric Acid
• Flavoxate
• Fluvoxamine
• food
• Fosinopril; Hydrochlorothiazide, HCTZ
• Furosemide
• Gefitinib
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Homatropine; Hydrocodone
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Idelalisib
• Indacaterol; Glycopyrrolate
• Iron
• Isavuconazonium
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Itraconazole
• Ketoconazole
• Ledipasvir; Sofosbuvir
• Letermovir
• Loop diuretics
• Lopinavir; Ritonavir
• Luliconazole
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Mefloquine
• Mepenzolate
• Mephobarbital
• Mesalamine, 5-ASA
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methotrexate
• Methscopolamine
• Methyclothiazide
• Methylphenidate
• Metolazone
• Mitotane
• Mycophenolate
• Nelfinavir
• Neratinib
• Nilotinib
• Octreotide
• Ombitasvir; Paritaprevir; Ritonavir
• Oritavancin
• Oxybutynin
• Pazopanib
• Pentobarbital
• Pexidartinib
• Phenobarbital
• Polyethylene Glycol; Electrolytes; Bisacodyl
• Ponatinib
• Posaconazole
• Primidone
• Propantheline
• Rifampin
• Rilpivirine
• Risedronate
• Ritonavir
• Saquinavir
• Scopolamine
• Secobarbital
• Secretin
• Selpercatinib
• Sofosbuvir; Velpatasvir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Solifenacin
• St. John’s Wort, Hypericum perforatum
• Sucralfate
• Tacrolimus
• Telaprevir
• Telithromycin
• Terbinafine
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiopental
• Thyroid hormones
• Tipranavir
• Tolterodine
• Torsemide
• Trihexyphenidyl
• Trospium
• Tucatinib
• Voriconazole
• Warfarin