Ixazomib Brand Name– NINLARO
What is Ixazomib
Ixazomib is a proteasome inhibitor that is indicated in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma in patients who have received at least 1 prior therapy.
Myelosuppression has been reported with ixazomib therapy; platelet transfusions may be necessary.
Indications
- multiple myeloma
For the treatment of multiple myeloma
NOTE: The FDA has designated ixazomib citrate as an orphan drug for the treatment of multiple myeloma.
Side Effects
- back pain
- back pain
- blurred vision
- conjunctivitis
- constipation
- constipation
- diarrhea
- diarrhea
- elevated hepatic enzymes
- encephalopathy
- hepatitis
- infection
- infection
- maculopapular rash
- maculopapular rash
- myelitis
- nausea
- nausea
- neutropenia
- neutropenia
- peripheral edema
- peripheral edema
- peripheral neuropathy
- peripheral neuropathy
- rash
- rash
- steatosis
- Stevens-Johnson syndrome
- thrombocytopenia
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- tumor lysis syndrome (TLS)
- vomiting
- vomiting
- xerophthalmia
Monitoring Parameters
- CBC with differential
- LFTs
- platelet count
- serum creatinine/BUN
Contraindications
- breast-feeding
- constipation
- contraception requirements
- diarrhea
- hemolytic-uremic syndrome
- hepatic disease
- hepatotoxicity
- male-mediated teratogenicity
- nausea/vomiting
- neutropenia
- peripheral edema
- peripheral neuropathy
- pregnancy
- renal impairment
- reproductive risk
- serious rash
- thrombocytopenia
- thrombotic microangiopathy
- thrombotic thrombocytopenic purpura (TTP)
Interactions
- Apalutamide
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Carbamazepine
- Enzalutamide
- Fosphenytoin
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Omeprazole; Amoxicillin; Rifabutin
- Phenobarbital
- Phenytoin
- Primidone
- Rifabutin
- Rifampin
- St. John’s Wort, Hypericum perforatum
