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Immune Globulin SC Brand Names
cutaquig | Cuvitru | Hizentra | Vivaglobulin | Xembify
What is Immune Globulin SC
Immune globulin subcutaneous (SCIG) is a protein solution that contains at least 98% immunoglobulin G (IgG). It is indicated for the treatment of primary immunoglobulin deficiency or chronic inflammatory demyelinating polyneuropathy (CIDP).
Lifelong replacement therapy with human immune globulin provides passive immunity to decrease susceptibility to life-threatening infections in patients with predominant antibody deficiencies.
Administration of SCIG is more frequent as compared with IVIG. The more frequent SCIG administration leads to more consistent serum IgG concentrations, with lower peaks, higher troughs, and relatively stable steady-state serum concentrations compared to the high peaks and low troughs seen with IVIG.
The fluctuating serum IgG concentrations seen with once monthly administration of IVIG are likely associated with certain adverse events (i.e., headaches seen with high peaks, fatigue, joint symptoms, and general malaise seen with low troughs).
The use of SCIG may decrease the incidence of such adverse events.
Indications
- agammaglobulinemia
- chronic inflammatory demyelinating polyneuropathy (CIDP)
- hypogammaglobulinemia
- immunoglobulin deficiency
- measles prophylaxis
For the treatment of primary immunoglobulin deficiency (e.g., agammaglobulinemia, hypogammaglobulinemia)
For use in patients switching from intravenous immune globulin or immune globulin infusion 10% with recombinant human hyaluronidase (Cuvitru)
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anaphylactic shock
- anaphylactoid reactions
- apnea
- arthralgia
- aseptic meningitis
- asthenia
- back pain
- bronchospasm
- chest pain (unspecified)
- chills
- coma
- cough
- cyanosis
- diarrhea
- dizziness
- dyspnea
- edema
- erythema
- fatigue
- fever
- flushing
- headache
- hemolysis
- hemolytic anemia
- hypertension
- hypotension
- hypoxia
- infection
- injection site reaction
- laryngospasm
- migraine
- nausea
- oliguria
- osmotic nephrosis
- pharyngitis
- pruritus
- pulmonary edema
- rash
- renal failure (unspecified)
- seizures
- sinus tachycardia
- thromboembolism
- thrombosis
- tremor
- urticaria
- vomiting
- weight gain
Monitoring Parameters
- serum IgG concentations
Contraindications
- agammaglobulinemia
- breast-feeding
- cardiac disease
- coronary artery disease
- dehydration
- diabetes mellitus
- geriatric
- heart failure
- hyperprolinemia
- hypertriglyceridemia
- hypogammaglobulinemia
- hyponatremia
- hypovolemia
- IgA deficiency
- intramuscular administration
- intravenous administration
- laboratory test interference
- obesity
- polysorbate 80 hypersensitivity
- pregnancy
- renal disease
- renal failure
- renal impairment
- sepsis
- thromboembolism
- vaccination
- viral infection
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acyclovir
- Adefovir
- Amikacin
- Aminoglycosides
- Amlodipine; Celecoxib
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bacitracin
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Capreomycin
- Celecoxib
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cisplatin
- Colistimethate, Colistin, Polymyxin E
- Cyclosporine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- Foscarnet
- Ganciclovir
- Gentamicin
- Hydrocodone; Ibuprofen
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Kanamycin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Magnesium Salicylate
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Pamidronate
- Paromomycin
- Pentamidine
- Piroxicam
- Plazomicin
- Polymyxin B
- Polymyxins
- Rofecoxib
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Salsalate
- Streptomycin
- Streptozocin
- Sulindac
- Tacrolimus
- Tobramycin
- Tolmetin
- Valacyclovir
- Valdecoxib
- Valganciclovir
- Vancomycin
- Varicella-Zoster Virus Vaccine, Live
- Zoledronic Acid
