Ibritumomab Tiuxetan

Ibritumomab Tiuxetan Brand Names- Zevalin for In-111 | Zevalin for Y-90

What is Ibritumomab Tiuxetan

Ibritumomab tiuxetan is a radiotherapeutic monoclonal antibody that binds to the CD20 molecule found on pre B- and mature B-lymphocytes.

It is indicated in combination with rituximab for relapsed or refractory, low-grade or follicular B-cell non-Hodgkin lymphoma (NHL) and previously untreated follicular NHL in patients who achieve a partial or complete response to first-line chemotherapy.

Serious infusion reactions, prolonged and severe cytopenias, and severe cutaneous and mucocutaneous reactions have been reported with ibritumomab tiuxetan therapy.

Indications

  • non-Hodgkin’s lymphoma (NHL)

For the treatment of non-Hodgkin’s lymphoma (NHL)

Side Effects

  1. abdominal pain
  2. abdominal pain
  3. acute respiratory distress syndrome (ARDS)
  4. anemia
  5. anemia
  6. angioedema
  7. anorexia
  8. antibody formation
  9. asthenia
  10. asthenia
  11. bone marrow suppression
  12. bronchospasm
  13. bullous rash
  14. cough
  15. cough
  16. diarrhea
  17. dizziness
  18. ecchymosis
  19. ecchymosis
  20. epistaxis
  21. epistaxis
  22. erythema
  23. erythema multiforme
  24. exfoliative dermatitis
  25. fatigue
  26. fatigue
  27. fever
  28. fever
  29. hypertension
  30. hypertension
  31. hypotension
  32. hypoxia
  33. infection
  34. infection
  35. influenza
  36. infusion-related reactions
  37. leukemia
  38. leukopenia
  39. leukopenia
  40. lymphopenia
  41. lymphopenia
  42. myalgia
  43. myocardial infarction
  44. nausea
  45. neutropenia
  46. neutropenia
  47. new primary malignancy
  48. night sweats
  49. petechiae
  50. petechiae
  51. pharyngitis
  52. pruritus
  53. rash
  54. rash
  55. rhinitis
  56. sinusitis
  57. sinusitis
  58. skin necrosis
  59. skin ulcer
  60. Stevens-Johnson syndrome
  61. thrombocytopenia
  62. thrombocytopenia
  63. toxic epidermal necrolysis
  64. urticaria
  65. ventricular fibrillation

Monitoring Parameters

  • CBC with differential
  • platelet count
  • pregnancy testing

Contraindications

  • accidental exposure
  • anticoagulant therapy
  • bleeding
  • bone marrow suppression
  • breast-feeding
  • contraception requirements
  • extravasation
  • infection
  • infertility
  • infusion-related reactions
  • male-mediated teratogenicity
  • neutropenia
  • new primary malignancy
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • serious rash
  • thrombocytopenia
  • vaccination

Interactions

  • Abciximab
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Alendronate; Cholecalciferol
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alpha interferons
  • Alteplase
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Amphetamines
  • Anagrelide
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Antacids
  • Anticholinergics
  • Anticoagulants
  • Antithrombin III
  • Antithymocyte Globulin
  • Apixaban
  • Argatroban
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Betamethasone
  • Betrixaban
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bivalirudin
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Burosumab
  • Caffeine
  • Calcium
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium; Vitamin D
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Celecoxib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpropamide
  • Choline Salicylate; Magnesium Salicylate
  • Ciclesonide
  • Cilostazol
  • Clopidogrel
  • Clozapine
  • Colchicine
  • Colchicine; Probenecid
  • Colestipol
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Deflazacort
  • Desirudin
  • Desloratadine; Pseudoephedrine
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazoxide
  • Dichlorphenamide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dicyclomine
  • Diflunisal
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dipyridamole
  • Donepezil; Memantine
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Echinacea
  • Edoxaban
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enoxaparin
  • Eplerenone
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eptifibatide
  • Erdafitinib
  • Ergocalciferol, Vitamin D2
  • Esomeprazole; Naproxen
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fexofenadine; Pseudoephedrine
  • Filgrastim, G-CSF
  • Flavoxate
  • Flecainide
  • Fludrocortisone
  • Flunisolide
  • Flurbiprofen
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fondaparinux
  • food
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Heparin
  • Hetastarch; Dextrose; Electrolytes
  • Homatropine; Hydrocodone
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indacaterol; Glycopyrrolate
  • Indomethacin
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Interferon Alfa-n3
  • Interferon Alfacon-1
  • Irbesartan
  • Iron
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lepirudin
  • Lisinopril
  • Lithium
  • Loperamide
  • Loperamide; Simethicone
  • Loratadine; Pseudoephedrine
  • Losartan
  • Magnesium
  • Magnesium Hydroxide
  • Magnesium Salicylate
  • Magnesium Salts
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Memantine
  • Mepenzolate
  • Methadone
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Methyldopa
  • Methylprednisolone
  • Moexipril
  • Mometasone
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nebivolol; Valsartan
  • Nonsteroidal antiinflammatory drugs
  • Olmesartan
  • Oxaprozin
  • Oxybutynin
  • Palifermin
  • Pegfilgrastim
  • Peginterferon Alfa-2a
  • Peginterferon Alfa-2b
  • Penicillamine
  • Penicillin G
  • Pentosan
  • Perindopril
  • Perindopril; Amlodipine
  • Piroxicam
  • Platelet Inhibitors
  • Potassium-sparing diuretics
  • Prasugrel
  • Prednisolone
  • Prednisone
  • Propantheline
  • Pseudoephedrine
  • Quinapril
  • Quinidine
  • Quinine
  • Ramipril
  • Reteplase, r-PA
  • Rivaroxaban
  • Rofecoxib
  • Sacubitril; Valsartan
  • Salsalate
  • Scopolamine
  • Sevelamer
  • Sodium Polystyrene Sulfonate
  • Spironolactone
  • Streptokinase
  • Sucralfate
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulindac
  • Tacrolimus
  • Tbo-Filgrastim
  • Telmisartan
  • Tenecteplase
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tolmetin
  • Tolvaptan
  • Trandolapril
  • Trandolapril; Verapamil
  • Triamcinolone
  • Triamterene
  • Trientine
  • Trihexyphenidyl
  • Trimethoprim
  • Tuberculin Purified Protein Derivative, PPD
  • Urokinase
  • Valdecoxib
  • Valsartan
  • Vitamin D
  • Vitamin D analogs
  • Vorapaxar
  • Warfarin
  • Zinc
  • Zinc Salts