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What is Hyqvia
Hyqvia is a subcutaneous immunoglobulin (SCIG) used with recombinant human hyaluronidase for the treatment of primary immunoglobulin deficiency. It is the first SCIG that requires just 1 infusion up to once per month.
At least 98% of the immune globulin protein is IgG. The product is a dual vial unit consisting of 1 vial of human immune globulin and 1 vial of recombinant human hyaluronidase.
Hyaluronidase is subcutaneously infused prior to infusion of SCIG, which increases the absorption and dispersion of immune globulin.
Lifelong replacement therapy with human immune globulin provides passive immunity to decrease susceptibility to life-threatening infections in patients with predominant antibody deficiencies.
The use of SCIG may decrease the incidence of systemic adverse events compared to IVIG; however, local reactions are more common.
Subcutaneous administration may be desirable for patients who have poor venous access.
Patients or caregivers can self-administer the immune globulin and hyaluronidase infusions at home with proper training.
Indications
- immunoglobulin deficiency
General dosing information:
- Initiate treatment using an interval/dosage ramp-up schedule, which allows for dosage escalation over 7 weeks to a target dose to be given every 3—4 weeks. During dosage escalation, the time intervals between doses increases.
- A full therapeutic dose may be administered in 1 site up to every 4 weeks.
- Consider drug volume, total infusion time, and tolerability when adjusting dosage frequency and number of infusion sites. Adjust the frequency of administration so that the patient receives the same weekly equivalent dose.
- Suggested sites for infusion are the middle to upper abdomen and thighs.
- Consider the use of a second infusion site or infusing at shorter intervals when the volume exceeds 300 ml for patients < 40 kg or 600 ml for patients >= 40 kg
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anaphylactic shock
- anaphylactoid reactions
- antibody formation
- anxiety
- apnea
- aseptic meningitis
- back pain
- bronchospasm
- bullous rash
- cardiac arrest
- coma
- cyanosis
- dyspnea
- erythema
- erythema multiforme
- fatigue
- fever
- headache
- hemolysis
- hemolytic anemia
- hyperhidrosis
- hypertension
- hypotension
- hypoxia
- infection
- injection site reaction
- insomnia
- leukopenia
- myocardial infarction
- nausea
- osmotic nephrosis
- pancytopenia
- pruritus
- pulmonary edema
- renal failure (unspecified)
- renal tubular necrosis
- seizures
- Stevens-Johnson syndrome
- thromboembolism
- tremor
- vomiting
Monitoring Parameters
- serum creatinine/BUN
- serum IgG concentations
Contraindications
- breast-feeding
- cardiac disease
- coronary artery disease
- dehydration
- diabetes mellitus
- geriatric
- heart failure
- hypertriglyceridemia
- hyponatremia
- hypovolemia
- IgA deficiency
- infection
- intramuscular administration
- intravenous administration
- obesity
- pregnancy
- renal disease
- renal failure
- renal impairment
- sepsis
- thromboembolism
- vaccination
- viral infection
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acyclovir
- Adefovir
- Amide local anesthetics
- Amikacin
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Amlodipine; Celecoxib
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bacitracin
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Capreomycin
- Celecoxib
- Chloroprocaine
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cisplatin
- Cocaine
- Colistimethate, Colistin, Polymyxin E
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Corticotropin, ACTH
- Cortisone
- Cyclosporine
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Esomeprazole; Naproxen
- Ester local anesthetics
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- Foscarnet
- Ganciclovir
- Gentamicin
- Hydrocodone; Ibuprofen
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Kanamycin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Levobupivacaine
- Lidocaine
- Lidocaine; Prilocaine
- Magnesium Salicylate
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Pamidronate
- Paromomycin
- Pentamidine
- Piroxicam
- Plazomicin
- Polymyxin B
- Polymyxins
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Rofecoxib
- Ropivacaine
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Salicylates
- Salsalate
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Streptomycin
- Streptozocin
- Sulindac
- Tacrolimus
- Tetracaine
- Tobramycin
- Tolmetin
- Valacyclovir
- Valdecoxib
- Valganciclovir
- Vancomycin
- Varicella-Zoster Virus Vaccine, Live
- Zoledronic Acid
