Hypoxia inducible factor prolyl hydroxylase inhibitors

What are hypoxia inducible factor prolyl hydroxylase inhibitors?

Several agents are under development that potentiate the activity of HIF, the substance in the kidney and other tissues that senses decreased delivery of oxygen (from hypoxemia or anemia) and stimulates the production of EPO.

In the absence of hypoxia, HIF is rapidly degraded by an enzyme, prolyl hydroxylase (HIF-PH). By inhibiting HIF-PH, these agents increase HIF and endogenous EPO activity.

These agents are orally active and effective, even in patients with ESRD, suggesting that significant EPO production can be induced in nonrenal tissues This is supported by the observation that HIF-PH inhibitors are effective in anephric patients with ESRD.

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