Hydroxyethyl Starch Brand Name– Voluven
What is Hydroxyethyl Starch
Hydroxyethyl starch (HES) is a hydroxyethyl synthetic colloidal starch. HES is used for the treatment of hypovolemia when plasma volume expansion is desired.
HES is derived from a waxy starch composed almost entirely of amylopectin.
The average molecular weight of HES is approximately 130,000 daltons.
HES was FDA-approved for the treatment of hypovolemia in December 2007.
Indications
- hypovolemia
For use as a plasma volume substitute in the treatment and prophylaxis of hypovolemia
Side Effects
- anaphylactoid reactions
- bleeding
- bradycardia
- bronchospasm
- chills
- coagulopathy
- cough
- hyperamylasemia
- hypotension
- pruritus
- pulmonary edema
- renal failure (unspecified)
- sinus tachycardia
- sneezing
Monitoring Parameters
- hemoglobin/hematocrit
- platelet count
- prothrombin time (PT)
- serum creatinine/BUN
- serum electrolytes
Contraindications
- anuria
- breast-feeding
- cardiac disease
- coagulopathy
- dehydration
- dialysis
- geriatric
- heart failure
- hepatic disease
- hydroxyethyl cellulose hypersensitivity
- hyperchloremia
- hypernatremia
- hypervolemia
- intracranial bleeding
- labor
- mortality
- obstetric delivery
- oliguria
- pregnancy
- pulmonary edema
- renal disease
- renal failure
- sepsis
- surgery
- von Willebrand’s disease
Interactions
- Azelastine; Fluticasone
- Beclomethasone
- Betamethasone
- Budesonide
- Budesonide; Formoterol
- Ciclesonide
- Corticosteroids
- Cortisone
- Deflazacort
- Dexamethasone
- Dichlorphenamide
- Fludrocortisone
- Flunisolide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Hydrocortisone
- Lithium
- Methylprednisolone
- Mometasone
- Prednisolone
- Prednisone
- Tolvaptan
- Triamcinolone
