Human Papillomavirus Quadrivalent Vaccine

Human Papillomavirus Quadrivalent Vaccine Brand Name– Gardasil

What is Human Papillomavirus Quadrivalent Vaccine

Human papillomavirus quadrivalent vaccine (Gardasil quadrivalent) is a recombinant vaccine indicated for the prevention of human papillomavirus (HPV) infections and the diseases associated with these infections.

The vaccine is only effective against the 4 HPV types contained within the vaccine, which include HPV types 6, 11, 16, and 18.

The other commercially available HPV vaccine, Gardasil 9, is effective against HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58. HPV vaccines are only prophylactic and will not treat an active HPV infection.

Therefore, to offer the greatest protection, it is recommended to administer the vaccine prior to exposure (i.e., before onset of sexual activity).

Patients with previous exposure to HPV may still achieve benefit from the vaccine; however, no clear evidence of protection from disease caused by HPV types for which patients are PCR positive or seropositive at baseline exists.

The duration of protection has not been clearly defined; however, data indicate no loss of protection from HPV vaccines after 8 to 10 years.

Human papillomavirus quadrivalent vaccine is FDA-approved for use in both females and males ages 9 to 26 years.

Indications

  • human papillomavirus (HPV) infection prophylaxis

Side Effects

  1. abdominal pain
  2. acute disseminated encephalomyelitis
  3. alopecia
  4. anaphylactic shock
  5. anaphylactoid reactions
  6. arthralgia
  7. asthenia
  8. bronchospasm
  9. chills
  10. cough
  11. dental pain
  12. diabetes mellitus
  13. diarrhea
  14. dizziness
  15. edema
  16. erythema
  17. erythema nodosum
  18. fatigue
  19. fever
  20. Guillain-Barre syndrome
  21. headache
  22. hematoma
  23. hemolytic anemia
  24. hyperthyroidism
  25. hypothyroidism
  26. infection
  27. injection site reaction
  28. insomnia
  29. lupus-like symptoms
  30. lymphadenopathy
  31. malaise
  32. muscle paralysis
  33. myalgia
  34. myocarditis
  35. nasal congestion
  36. nausea
  37. optic neuritis
  38. pancreatitis
  39. pharyngitis
  40. proteinuria
  41. pruritus
  42. psoriasis
  43. pulmonary embolism
  44. purpura
  45. seizures
  46. skin hypopigmentation
  47. Stevens-Johnson syndrome
  48. syncope
  49. thrombocytopenia
  50. thrombosis
  51. urticaria
  52. uveitis
  53. vomiting

Monitoring Parameters

  • pap smear
  • pelvic exam

Contraindications

  • agammaglobulinemia
  • anticoagulant therapy
  • breast-feeding
  • children
  • coagulopathy
  • fever
  • hemophilia
  • human immunodeficiency virus (HIV) infection
  • hypogammaglobulinemia
  • immunosuppression
  • infants
  • neonates
  • neoplastic disease
  • pregnancy
  • radiation therapy
  • severe combined immunodeficiency (SCID)
  • syncope
  • thrombocytopenia
  • vitamin K deficiency
  • yeast hypersensitivity

Interactions

  • Ocrelizumab
  • Siponimod
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