How can the risk of uric acid nephropathy and nephrolithiasis be minimized when prescribing uricosurics?
1. Adequate fluid intake, 2 L/day.
2. Urine alkalinization (not needed in most patients); may use sodium bicarbonate (3–7.5 g daily) or potassium citrate (7.5 g daily) to maintain an alkaline urine (pH > 6.0).
