how baclofen might be used to treat spasticity
Baclofen is believed to act on presynaptic mechanisms to enhance gamma-aminobutyric acid (GABA) activity as well as to reduce the release of various excitatory neurotransmitters. Although originally developed in the United States for spasticity associated with multiple sclerosis, it has been prescribed for many other conditions associated with spasticity. Up-to-date recommends for spasticity: Oral: Initial: 5 mg 3 times daily; may increase by 5 mg per dose every 3 days (i.e., 5 mg 3 times daily for 3 days, then 10 mg 3 times daily for 3 days, etc.), until optimal response is reached. Usual dosage range: 40 to 80 mg daily. Do not exceed 80 mg daily (20 mg 4 times daily). Side effects include drowsiness, insomnia, dizziness, weakness, and confusion.
