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Histrelin Brand Names- Supprelin | Vantas
What is Histrelin
Histrelin acetate is a synthetic nonapeptide analog of gonadotropin releasing hormone (GnRH); the implant is a sterile, non-biodegradable, diffusion-controlled hydrogel polymer reservoir.
Histrelin functions as a GnRH agonist, and is a potent inhibitor of gonadotropin secretion when given continuously at therapeutic doses.
It is FDA approved for the palliative treatment of advanced prostate cancer and for the treatment of central precocious puberty. Initial transient increases of estradiol and/or testosterone may cause a temporary worsening of symptoms.
However, testosterone concentrations in men being treated for advanced prostate cancer are reduced to castration levels within 2 to 4 weeks of starting therapy. In pediatric patients, LH levels decrease to prepubertal levels within 1 month of treatment, with a resultant decrease in the serum concentrations of sex steroids (i.e., estrogen or testosterone). Implant insertion is a surgical procedure.
Indications
- precocious puberty
- prostate cancer
For the palliative treatment of advanced prostate cancer
Side Effects
- abdominal pain
- amblyopia
- anaphylactoid reactions
- anemia
- appetite stimulation
- arthralgia
- back pain
- bone pain
- breast enlargement
- constipation
- depression
- diabetes mellitus
- diaphoresis
- dizziness
- dysmenorrhea
- dyspnea
- dysuria
- ecchymosis
- edema
- elevated hepatic enzymes
- emotional lability
- epistaxis
- erythema
- fatigue
- flushing
- gynecomastia
- headache
- hematoma
- hematuria
- hot flashes
- hot flashes
- hypercalcemia
- hypercholesterolemia
- hyperglycemia
- hyperhidrosis
- hypertrichosis
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- influenza
- injection site reaction
- insomnia
- irritability
- lethargy
- libido decrease
- malaise
- menorrhagia
- migraine
- myalgia
- myocardial infarction
- nausea
- neuropathic pain
- night sweats
- osteopenia
- osteoporosis
- palpitations
- pituitary apoplexy
- pruritus
- QT prolongation
- renal failure (unspecified)
- seizures
- spinal cord compression
- stroke
- suicidal ideation
- testicular atrophy
- tremor
- tumor flare
- urinary retention
- vaginal bleeding
- visual impairment
- vomiting
- weakness
- weight gain
- weight loss
Monitoring Parameters
- blood glucose
- ECG
- glycosylated hemoglobin A1c (HbA1c)
- prostate-specific antigen (PSA)
- serum electrolytes
- serum estradiol concentrations
- serum gonadotropin concentrations
- serum testosterone concentrations
Contraindications
- apheresis
- AV block
- bladder obstruction
- bradycardia
- breast-feeding
- cardiac disease
- cardiomyopathy
- celiac disease
- children
- depression
- diabetes mellitus
- electrolyte imbalance
- females
- fever
- geriatric
- Gonadotropin-Releasing Hormone (GnRH) analogs hypersensitivity
- heart failure
- human immunodeficiency virus (HIV) infection
- hyperglycemia
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infants
- long QT syndrome
- myocardial infarction
- neonates
- osteoporosis
- pheochromocytoma
- pituitary insufficiency
- pregnancy
- QT prolongation
- renal impairment
- rheumatoid arthritis
- seizure disorder
- sickle cell disease
- sleep deprivation
- spinal cord compression
- stroke
- suicidal ideation
- systemic lupus erythematosus (SLE)
- urinary tract obstruction
Interactions
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Androgens
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atomoxetine
- Azithromycin
- Bedaquiline
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brexpiprazole
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Cariprazine
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Danazol
- Dasatinib
- Desflurane
- Desipramine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esterified Estrogens; Methyltestosterone
- Ezogabine
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluoxymesterone
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Granisetron
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Isoflurane
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lefamulin
- Lenvatinib
- Levalbuterol
- Levofloxacin
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorcaserin
- Loxapine
- Macimorelin
- Maprotiline
- Mefloquine
- Meperidine; Promethazine
- Metaproterenol
- Methadone
- Methyldopa
- Methyltestosterone
- Metoclopramide
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Molindone
- Moxifloxacin
- Nandrolone Decanoate
- Nilotinib
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxandrolone
- Oxymetholone
- Ozanimod
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Pitolisant
- Posaconazole
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Primaquine
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Romidepsin
- Salmeterol
- Saquinavir
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Terbutaline
- Testolactone
- Testosterone
- Tetrabenazine
- Thioridazine
- Thiothixene
- Tiotropium; Olodaterol
- Tolterodine
- Toremifene
- Trandolapril; Verapamil
- Trazodone
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Verapamil
- Voriconazole
- Vorinostat
- Ziprasidone
