Halobetasol Tazarotene Brand Name– Duobrii
What is Halobetasol Tazarotene
Halobetasol tazarotene is a topical product that combines a very high potency, fluorinated corticosteroid with a retinoid to treat plaque psoriasis in adults.
The drug is dosed once daily, and should not be applied to the face, groin, or in the axillae. Long-term or extensive use may lead to systemic side effects, including hypothalamic-pituitary-adrenal (HPA) axis suppression.
Halobetasol tazarotene is contraindicated for use during pregnancy; females of childbearing potential should undergo pregnancy testing within 2 weeks of initiating treatment, and use adequate birth control during treatment.
Indications
- psoriasis
General Comparative Topical Corticosteroid Potency:
NOTE: The following is a general representation. Check specific product formulations prior to making potency decisions.
Very High Potency
Betamethasone dipropionate (augmented)
Clobetasol
Diflorasone diacetate ointment
Halobetasol
High Potency
Amcinonide
Betamethasone dipropionate
Desoximetasone gel or ointment, or cream 0.25% or more
Diflorasone diacetate cream
Fluocinolone cream 0.2% or more
Fluocinonide
Halcinonide
Triamcinolone 0.5% or more
Medium Potency
Beclomethasone
Betamethasone benzoate
Betamethasone valerate
Clobetasone
Desoximetasone cream less than 0.25%
Diflucortolone
Fluocinolone ointment or topical solution or cream less than 0.2%
Flurandrenolide 0.025% or more
Fluticasone
Hydrocortisone butyrate
Hydrocortisone valerate
Mometasone
Prednicarbate
Triamcinolone less than 0.5%
Low Potency
Alclometasone
Clocortolone
Desonide
Dexamethasone
Flumethasone
Flurandrenolide less than 0.025%
Hydrocortisone base
Hydrocortisone acetate
Side Effects
- adrenocortical insufficiency
- cataracts
- contact dermatitis
- Cushing’s syndrome
- folliculitis
- glycosuria
- growth inhibition
- headache
- hyperglycemia
- hypothalamic-pituitary-adrenal (HPA) suppression
- impaired wound healing
- increased intracranial pressure
- ocular hypertension
- papilledema
- photosensitivity
- pseudotumor cerebri
- rash
- skin atrophy
- striae
- telangiectasia
- visual impairment
Monitoring Parameters
- pregnancy testing
Contraindications
- accidental exposure
- breast-feeding
- cataracts
- children
- contraception requirements
- Cushing’s syndrome
- diabetes mellitus
- eczema
- females
- glaucoma
- growth inhibition
- hepatic disease
- hypothalamic-pituitary-adrenal (HPA) suppression
- increased intracranial pressure
- infants
- neonates
- occlusive dressing
- ocular exposure
- pregnancy
- pregnancy testing
- skin abrasion
- skin photosensitivity disorder
- sunburn
- sunlight (UV) exposure
Interactions
- Acetohexamide
- Adapalene; Benzoyl Peroxide
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Atenolol; Chlorthalidone
- Azilsartan; Chlorthalidone
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzoyl Peroxide
- Benzoyl Peroxide; Clindamycin
- Benzoyl Peroxide; Erythromycin
- Benzoyl Peroxide; Sulfur
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Chlorothiazide
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Ciprofloxacin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dextromethorphan; Promethazine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan; Hydrochlorothiazide, HCTZ
- Fluphenazine
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gemifloxacin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Griseofulvin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Indapamide
- Levofloxacin
- Meperidine; Promethazine
- Mesoridazine
- Methyclothiazide
- Metolazone
- Moxifloxacin
- Norfloxacin
- Ofloxacin
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Prochlorperazine
- Promethazine
- St. John’s Wort, Hypericum perforatum
- Sulfonylureas
- Tetracyclines
- Thiazide diuretics
- Thiethylperazine
- Thioridazine
- Tolazamide
- Tolbutamide
- Trifluoperazine
