Gilteritinib Brand Name– XOSPATA
What is Gilteritinib
Gilteritinib is an oral tyrosine kinase inhibitor that inhibits mutant FLT3.
It is indicated for the treatment of relapsed or refractory FLT3 mutation-positive acute myelogenous leukemia as detected by an FDA-approved test.
Differentiation syndrome, posterior reversible encephalopathy syndrome, pancreatitis, and QT prolongation has been reported with gilteritinib therapy.
Indications
- acute myelogenous leukemia (AML)
For the treatment of acute myelogenous leukemia (AML)
NOTE: Gilteritinib has been designated an orphan drug by the FDA for the treatment of AML.
for the treatment of relapsed or refractory FLT3 mutation-positive AML
Side Effects
- abdominal pain
- acne vulgaris
- acneiform rash
- anaphylactoid reactions
- angioedema
- arthralgia
- arthralgia
- asthenia
- back pain
- bone pain
- bullous rash
- cardiac arrest
- cardiomyopathy
- colitis
- constipation
- constipation
- contact dermatitis
- cough
- cough
- diarrhea
- differentiation syndrome
- dizziness
- dysgeusia
- dyspnea
- dyspnea
- edema
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- encephalopathy
- erythema
- erythema
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fatigue
- fever
- fever
- GI perforation
- headache
- heart failure
- hepatotoxicity
- hyperamylasemia
- hyperesthesia
- hyperkeratosis
- hypertriglyceridemia
- hypocalcemia
- hypoesthesia
- hyponatremia
- hypophosphatemia
- hypotension
- hypotension
- hypoxia
- infection
- insomnia
- lethargy
- leukocytosis
- maculopapular rash
- malaise
- malaise
- muscle cramps
- musculoskeletal pain
- myalgia
- myalgia
- myocarditis
- nausea
- nephrotoxicity
- neutropenia
- oral ulceration
- oral ulceration
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- pancreatitis
- paresthesias
- peptic ulcer
- pericardial effusion
- pericarditis
- peripheral edema
- peripheral neuropathy
- pleural effusion
- QT prolongation
- rash
- rash
- seizures
- skin hyperpigmentation
- skin ulcer
- stomatitis
- urticaria
- vomiting
- weight gain
Monitoring Parameters
- CBC with differential
- creatine phosphokinase (CPK)
- ECG
- pregnancy testing
- serum electrolytes
Contraindications
- apheresis
- arthralgia
- AV block
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- contraception requirements
- differentiation syndrome
- electrolyte imbalance
- females
- fever
- geriatric
- heart failure
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- long QT syndrome
- male-mediated teratogenicity
- myocardial infarction
- pheochromocytoma
- pregnancy
- pregnancy testing
- QT prolongation
- renal impairment
- reproductive risk
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
Interactions
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apalutamide
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Chloroquine
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- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
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- Encorafenib
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