Furosemide

Furosemide Brand Names- Delone | Lasix

What is Furosemide

Furosemide is a sulfonamide-derived loop diuretic used in the management of edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.

Other uses include mild to moderate hypertension and as an adjunct in hypertensive crisis and acute pulmonary edema.

Furosemide is also useful in treating hypercalcemia, although it is not FDA approved for this indication.

Furosemide is effective in managing edema associated with congestive heart failure, and it may be useful in patients who are unresponsive to other diuretics or who have severe renal impairment.

Furosemide was approved by the FDA in 1966.

Indications

1. ascites
2. chronic lung disease (CLD)
3. edema
4. heart failure
5. hypercalcemia
6. hypertension
7. hypertensive emergency
8. hypertensive urgency
9. nephrotic syndrome
10. pulmonary edema
11. renal impairment

For the treatment of peripheral edema or edema associated with heart failure, chronic lung disease (CLD), or nephrotic syndrome

Side Effects

1. abdominal pain
2. acute generalized exanthematous pustulosis (AGEP)
3. agranulocytosis
4. anaphylactic shock
5. anaphylactoid reactions
6. anemia
7. anorexia
8. aplastic anemia
9. azotemia
10. bladder spasm
11. blurred vision
12. bullous rash
13. cholestasis
14. constipation
15. diabetes mellitus
16. diarrhea
17. dizziness
18. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
19. elevated hepatic enzymes
20. eosinophilia
21. erythema multiforme
22. exfoliative dermatitis
23. fever
24. glycosuria
25. gout
26. headache
27. hearing loss
28. hemolytic anemia
29. hepatic encephalopathy
30. hypercholesterolemia
31. hyperglycemia
32. hypertriglyceridemia
33. hyperuricemia
34. hypocalcemia
35. hypochloremia
36. hypokalemia
37. hypomagnesemia
38. hyponatremia
39. hypovolemia
40. injection site reaction
41. interstitial nephritis
42. jaundice
43. leukopenia
44. metabolic alkalosis
45. muscle cramps
46. nausea
47. oliguria
48. orthostatic hypotension
49. pancreatitis
50. paresthesias
51. phlebitis
52. photosensitivity
53. polyuria
54. pruritus
55. purpura
56. rash
57. restlessness
58. Stevens-Johnson syndrome
59. syncope
60. thrombocytopenia
61. thromboembolism
62. thrombosis
63. tinnitus
64. toxic epidermal necrolysis
65. urticaria
66. vasculitis
67. vertigo
68. vomiting
69. weakness
70. xanthopsia

Monitoring Parameters

• audiometry
• blood glucose
• blood pressure
• serum creatinine/BUN
• serum electrolytes
• serum uric acid

Contraindications

• acid/base imbalance
• acute myocardial infarction
• anuria
• ascites
• breast-feeding
• children
• diabetes mellitus
• diarrhea
• electrolyte imbalance
• geriatric
• gout
• hearing impairment
• heart failure
• hepatic disease
• hepatic encephalopathy
• hyperglycemia
• hyperuricemia
• hypocalcemia
• hypochloremia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• infants
• metabolic alkalosis
• neonates
• orthostatic hypotension
• pancreatitis
• pregnancy
• premature neonates
• prostatic hypertrophy
• renal disease
• renal failure
• renal impairment
• sulfonamide hypersensitivity
• sympathectomy
• syncope
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity
• thyroid disease
• urethral stricture
• urinary retention
• ventricular arrhythmias

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