Frovatriptan

Frovatriptan Brand Name– Frova

What is Frovatriptan

Frovatriptan is a central serotonin-receptor 1B and 1D agonist that is indicated for the treatment of acute migraine attacks with or without aura.

Frovatriptan is not indicated for the treatment of hemiplegic or basilar migraines or cluster headaches. The drug may be used off-label for menstrual migraine prophylaxis.

As with other second-generation 5-HT₁ receptor agonists (“triptans”), frovatriptan is more lipophilic than sumatriptan.

Frovatriptan was also found to be a more potent contractile agent, compared to sumatriptan, on isolated basilar artery tissue.

Frovatriptan has a lower headache recurrence rate, compared to other agents in the triptan class, which may be explained by the long (26 hour) half-life, as well as the increased lipophilicity and potent contractile effects of this drug. Frovatriptan was approved by the FDA in November 2001.

Indications

• menstrual migraine prophylaxis
• migraine

For the treatment of acute migraine headache attacks with or without aura

Side Effects

1. abdominal pain
2. agitation
3. amnesia
4. anaphylactoid reactions
5. angina
6. angioedema
7. anorexia
8. arrhythmia exacerbation
9. arthralgia
10. asthenia
11. ataxia
12. back pain
13. bowel ischemia
14. bradycardia
15. bullous rash
16. cheilitis
17. chest pain (unspecified)
18. chest pressure syndrome
19. colitis
20. confusion
21. conjunctivitis
22. constipation
23. coronary vasospasm
24. dehydration
25. dental pain
26. depression
27. diarrhea
28. dizziness
29. dysarthria
30. dysesthesia
31. dysgeusia
32. dyspepsia
33. dysphagia
34. dyspnea
35. edema
36. emotional lability
37. epistaxis
38. eructation
39. euphoria
40. fatigue
41. fever
42. flatulence
43. flushing
44. gastroesophageal reflux
45. headache
46. hiccups
47. hot flashes
48. hyperacusis
49. hyperesthesia
50. hyperhidrosis
51. hypersalivation
52. hypertensive crisis
53. hyperthermia
54. hypertonia
55. hyperventilation
56. hypocalcemia
57. hypoesthesia
58. hypoglycemia
59. hypotonia
60. increased urinary frequency
61. insomnia
62. intracranial bleeding
63. laryngitis
64. malaise
65. migraine
66. muscle cramps
67. musculoskeletal pain
68. myalgia
69. myasthenia
70. myocardial infarction
71. nausea
72. nocturia
73. ocular pain
74. otalgia
75. palpitations
76. paresthesias
77. peptic ulcer
78. peripheral vasoconstriction
79. pharyngitis
80. polydipsia
81. polyuria
82. pruritus
83. purpura
84. rhinitis
85. seizures
86. serotonin syndrome
87. sinus tachycardia
88. sinusitis
89. stomatitis
90. stroke
91. syncope
92. tinnitus
93. tremor
94. ventricular fibrillation
95. ventricular tachycardia
96. vertigo
97. visual impairment
98. vomiting
99. withdrawal
100. xerostomia

Monitoring Parameters

• ECG

Contraindications

• acute myocardial infarction
• angina
• arteriosclerosis
• basilar/hemiplegic migraine
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cerebrovascular disease
• children
• colitis
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• geriatric
• hepatic disease
• hypercholesterolemia
• hypertension
• infants
• intracranial bleeding
• myocardial infarction
• neonates
• obesity
• peripheral vascular disease
• pregnancy
• Raynaud’s phenomenon
• stroke
• tobacco smoking
• vasospastic angina
• visual disturbance
• Wolff-Parkinson-White syndrome

Interactions

• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Tramadol
• Alfentanil
• Almotriptan
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Bromocriptine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Citalopram
• Clomipramine
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Desipramine
• Desvenlafaxine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextroamphetamine
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Doxepin
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Droxidopa
• Duloxetine
• Eletriptan
• Ergot alkaloids
• Escitalopram
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Fenfluramine
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluvoxamine
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Homatropine; Hydrocodone
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Imipramine
• Isocarboxazid
• Lasmiditan
• Levomilnacipran
• Levorphanol
• Linezolid
• Lisdexamfetamine
• Lithium
• Lorcaserin
• Meperidine
• Meperidine; Promethazine
• Methadone
• Methamphetamine
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methylene Blue
• Milnacipran
• Mirtazapine
• Morphine
• Morphine; Naltrexone
• Nalbuphine
• Naproxen; Sumatriptan
• Naratriptan
• Nefazodone
• Nortriptyline
• Oxycodone
• Oxymorphone
• Ozanimod
• Paroxetine
• Perphenazine; Amitriptyline
• Phenelzine
• Protriptyline
• Rasagiline
• Remifentanil
• Rizatriptan
• Segesterone Acetate; Ethinyl Estradiol
• Selective serotonin reuptake inhibitors
• Selegiline
• Sertraline
• Sibutramine
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sumatriptan
• Tapentadol
• Tedizolid
• Thiabendazole
• Tramadol
• Tranylcypromine
• Trazodone
• Tricyclic antidepressants
• Trimipramine
• Venlafaxine
• Vilazodone
• Vortioxetine
• Zolmitriptan