Follitropin r FSH

Follitropin r FSH Brand Names

Follistim | Follistim AQ | Gonal-f | Gonal-f RFF | Gonal-f RFF Redi-ject

What is Follitropin r FSH

Follitropin r FSH is a recombinant version of human follicle stimulating hormone (FSH).

Follitropin is available as follitropin alfa and follitropin beta, both of which are synthesized using a Chinese hamster ovary cell line.

Although the products possess slightly different structures, they are indistinguishable based on data derived from physio-chemical tests and bioassay.

Neither follitropin alfa nor follitropin beta should be confused with urofollitropin, which is a preparation of FSH obtained from the urine of postmenopausal females and is not a recombinant product.

However, the primary and tertiary structures of follitropin alfa and follitropin beta are identical to that of human urinary FSH. Gonal-F, Gonal F RFF, and Follistim QA are indicated in women for the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of infertility is functional and not due to primary ovarian failure. 

Gonal-f and Gonal F RFF are both indicated in women for the development of multiple follicles in the ovulatory patient participating in an Assisted Reproductive Technology (ART) program.

Follistim AQ indicated in women for pregnancy in normal ovulatory women undergoing controlled ovarian stimulation as part of an in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) Cycle.

Gonal-F and Follistim AQ are approved in men for the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the cause of infertility is not due to primary testicular failure.

Indications

  1. hypogonadism
  2. infertility
  3. oligospermia

For the treatment of infertility in females

for the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of infertility is functional and not due to primary ovarian failure

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. acute respiratory distress syndrome (ARDS)
  4. anaphylactoid reactions
  5. anasarca
  6. anorexia
  7. anxiety
  8. ascites
  9. back pain
  10. breast enlargement
  11. candidiasis
  12. chest pain (unspecified)
  13. chills
  14. constipation
  15. cough
  16. cystitis
  17. dental pain
  18. diarrhea
  19. dizziness
  20. drowsiness
  21. dysmenorrhea
  22. dyspepsia
  23. dyspnea
  24. ectopic pregnancy
  25. fatigue
  26. fever
  27. flatulence
  28. fluid retention
  29. gynecomastia
  30. headache
  31. hemoptysis
  32. hot flashes
  33. hypotension
  34. hypovolemia
  35. increased urinary frequency
  36. infection
  37. injection site reaction
  38. leukorrhea
  39. malaise
  40. mastalgia
  41. menstrual irregularity
  42. migraine
  43. myalgia
  44. nausea
  45. new primary malignancy
  46. oliguria
  47. ovarian enlargement
  48. ovarian hyperstimulation syndrome (OHSS)
  49. palpitations
  50. paresthesias
  51. pelvic pain
  52. pericardial effusion
  53. pharyngitis
  54. phlebitis
  55. pleural effusion
  56. pruritus
  57. pulmonary edema
  58. pulmonary embolism
  59. rash
  60. rhinitis
  61. sinusitis
  62. spontaneous fetal abortion
  63. stomatitis
  64. stroke
  65. testicular pain
  66. thromboembolism
  67. thrombosis
  68. vaginal bleeding
  69. vaginal discharge
  70. vomiting
  71. weight gain

Monitoring Parameters

  • pelvic exam
  • pelvic ultrasound
  • pregnancy testing
  • serum estradiol concentrations
  • serum gonadotropin concentrations
  • serum testosterone concentrations
  • weight

Contraindications

  • adrenal insufficiency
  • ascites
  • breast cancer
  • breast-feeding
  • children
  • ectopic pregnancy
  • endometriosis
  • infants
  • myocardial infarction
  • neomycin hypersensitivity
  • obesity
  • ovarian cancer
  • ovarian cyst
  • ovarian failure
  • pituitary adenoma
  • polycystic ovary syndrome
  • pregnancy
  • pregnancy testing
  • requires an experienced clinician
  • streptomycin hypersensitivity
  • stroke
  • testicular failure
  • thromboembolic disease
  • thrombophlebitis
  • thyroid disease
  • tobacco smoking
  • uterine cancer
  • uterine leiomyomata
  • vaginal bleeding
  • visual impairment

Interactions

There are no drug interactions associated with Follitropin r FSH products.