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Follitropin r FSH Brand Names
Follistim | Follistim AQ | Gonal-f | Gonal-f RFF | Gonal-f RFF Redi-ject
What is Follitropin r FSH
Follitropin r FSH is a recombinant version of human follicle stimulating hormone (FSH).
Follitropin is available as follitropin alfa and follitropin beta, both of which are synthesized using a Chinese hamster ovary cell line.
Although the products possess slightly different structures, they are indistinguishable based on data derived from physio-chemical tests and bioassay.
Neither follitropin alfa nor follitropin beta should be confused with urofollitropin, which is a preparation of FSH obtained from the urine of postmenopausal females and is not a recombinant product.
However, the primary and tertiary structures of follitropin alfa and follitropin beta are identical to that of human urinary FSH. Gonal-F, Gonal F RFF, and Follistim QA are indicated in women for the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of infertility is functional and not due to primary ovarian failure.
Gonal-f and Gonal F RFF are both indicated in women for the development of multiple follicles in the ovulatory patient participating in an Assisted Reproductive Technology (ART) program.
Follistim AQ indicated in women for pregnancy in normal ovulatory women undergoing controlled ovarian stimulation as part of an in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) Cycle.
Gonal-F and Follistim AQ are approved in men for the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the cause of infertility is not due to primary testicular failure.
Indications
- hypogonadism
- infertility
- oligospermia
For the treatment of infertility in females
for the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of infertility is functional and not due to primary ovarian failure
Side Effects
- abdominal pain
- acne vulgaris
- acute respiratory distress syndrome (ARDS)
- anaphylactoid reactions
- anasarca
- anorexia
- anxiety
- ascites
- back pain
- breast enlargement
- candidiasis
- chest pain (unspecified)
- chills
- constipation
- cough
- cystitis
- dental pain
- diarrhea
- dizziness
- drowsiness
- dysmenorrhea
- dyspepsia
- dyspnea
- ectopic pregnancy
- fatigue
- fever
- flatulence
- fluid retention
- gynecomastia
- headache
- hemoptysis
- hot flashes
- hypotension
- hypovolemia
- increased urinary frequency
- infection
- injection site reaction
- leukorrhea
- malaise
- mastalgia
- menstrual irregularity
- migraine
- myalgia
- nausea
- new primary malignancy
- oliguria
- ovarian enlargement
- ovarian hyperstimulation syndrome (OHSS)
- palpitations
- paresthesias
- pelvic pain
- pericardial effusion
- pharyngitis
- phlebitis
- pleural effusion
- pruritus
- pulmonary edema
- pulmonary embolism
- rash
- rhinitis
- sinusitis
- spontaneous fetal abortion
- stomatitis
- stroke
- testicular pain
- thromboembolism
- thrombosis
- vaginal bleeding
- vaginal discharge
- vomiting
- weight gain
Monitoring Parameters
- pelvic exam
- pelvic ultrasound
- pregnancy testing
- serum estradiol concentrations
- serum gonadotropin concentrations
- serum testosterone concentrations
- weight
Contraindications
- adrenal insufficiency
- ascites
- breast cancer
- breast-feeding
- children
- ectopic pregnancy
- endometriosis
- infants
- myocardial infarction
- neomycin hypersensitivity
- obesity
- ovarian cancer
- ovarian cyst
- ovarian failure
- pituitary adenoma
- polycystic ovary syndrome
- pregnancy
- pregnancy testing
- requires an experienced clinician
- streptomycin hypersensitivity
- stroke
- testicular failure
- thromboembolic disease
- thrombophlebitis
- thyroid disease
- tobacco smoking
- uterine cancer
- uterine leiomyomata
- vaginal bleeding
- visual impairment
Interactions
There are no drug interactions associated with Follitropin r FSH products.
