Flutamide Brand Name– Eulexin
What is Flutamide
Flutamide is an oral nonsteroidal antiandrogen used as an antihormonal agent in the treatment of metastatic prostatic carcinoma.
The drug is most effective when used simultaneously with LHRH agonists such as leuprolide acetate.
Flutamide is not effective in treating other hormonally dependent diseases such as breast cancer or benign prostatic hypertrophy.
Flutamide was originally approved by the FDA in January 1989 for the treatment of stage D2 metastatic prostate carcinoma. In June 1996, it was subsequently approved for treatment of stages B2 and C, in combination with LHRH agonists.
Indications
- prostate cancer
For the treatment of prostate cancer
for the treatment of locally confined Stage B2-C and Stage D2 prostate cancer in combination with leuteinizing hormone-releasing hormone (LHRH) analogs and radiation therapy
Side Effects
- abdominal pain
- anemia
- anorexia
- anxiety
- cholestasis
- confusion
- depression
- diarrhea
- diarrhea
- drowsiness
- edema
- elevated hepatic enzymes
- fatigue
- gynecomastia
- hemolytic anemia
- hepatic encephalopathy
- hepatic failure
- hepatic necrosis
- hepatitis
- hot flashes
- hyperbilirubinemia
- hypertension
- impotence (erectile dysfunction)
- jaundice
- leukopenia
- libido decrease
- methemoglobinemia
- nausea
- new primary malignancy
- photosensitivity
- rash
- thrombocytopenia
- urine discoloration
- vomiting
Monitoring Parameters
- CBC
- LFTs
Contraindications
- breast-feeding
- females
- G6PD deficiency
- hemoglobinopathy
- hepatic disease
- lactase deficiency
- polycystic ovary syndrome
- pregnancy
- tobacco smoking
Interactions
- Acetaminophen; Hydrocodone
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Aprepitant, Fosaprepitant
- Articaine; Epinephrine
- Atazanavir
- Atazanavir; Cobicistat
- Boceprevir
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chloroprocaine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Ciprofloxacin
- Cobicistat
- Cobimetinib
- Daclatasvir
- Dapsone
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Deflazacort
- Diphenhydramine; Hydrocodone; Phenylephrine
- Dolutegravir; Rilpivirine
- Doxorubicin
- Dronabinol
- Dronedarone
- Elbasvir; Grazoprevir
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- food
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Idelalisib
- Isavuconazonium
- Lidocaine
- Lidocaine; Prilocaine
- Loperamide
- Loperamide; Simethicone
- Maraviroc
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mitotane
- Obeticholic Acid
- Pazopanib
- Peginterferon Alfa-2b
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Perindopril; Amlodipine
- Pexidartinib
- Posaconazole
- Praziquantel
- Prilocaine
- Prilocaine; Epinephrine
- Rilpivirine
- Riluzole
- Rivaroxaban
- Romidepsin
- Ropivacaine
- Ruxolitinib
- Simeprevir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Telaprevir
- Telotristat Ethyl
- Terbinafine
- Tetracaine
- Tolvaptan
- Trabectedin
- Ulipristal
- Vemurafenib
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Warfarin
