Fluorouracil 5 FU Diclofenac Brand Name– FLUORAC
What is Fluorouracil 5 FU Diclofenac
Fluorouracil 5 FU Diclofenac is a topical preparation containing the fluorinated pyrimidine 5-fluorouracil, an antineiplastic antimetabolite and diclofenac sodium, a nonsteroidal anti-inflammatory.
Fluorouracil (5-FU) is a fluorinated pyrimidine and acts as an antimetabolite antineoplastic agent. It differs from the naturally occurring product, uracil, by the addition of a fluoride at position 5.
Fluorouracil 5 FU Diclofenac was introduced January 2015.
Indications
- actinic keratosis
- basal cell carcinoma
For the treatment of actinic keratosis (multiple actinic or solar keratosis)
Side Effects
- alopecia
- anaphylactoid reactions
- contact dermatitis
- dysgeusia
- edema
- elevated hepatic enzymes
- eosinophilia
- exfoliative dermatitis
- fluid retention
- GI bleeding
- GI perforation
- hypertension
- ichthyosis
- insomnia
- irritability
- lacrimation
- leukocytosis
- myocardial infarction
- nasal irritation
- pruritus
- rash
- renal papillary necrosis
- Stevens-Johnson syndrome
- stomatitis
- stroke
- teratogenesis
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- accidental exposure
- alcoholism
- breast-feeding
- cardiac disease
- coronary artery bypass graft surgery (CABG)
- dihydropyrimidine dehydrogenase (DPD) deficiency
- geriatric
- GI bleeding
- GI perforation
- heart failure
- hepatic disease
- hypertension
- NSAID hypersensitivity
- occlusive dressing
- peptic ulcer disease
- pregnancy
- renal impairment
- salicylate hypersensitivity
- sunlight (UV) exposure
- tobacco smoking
- ulcerative colitis
Interactions
There are no drug interactions associated with Fluorouracil, 5-FU; Diclofenac products.
