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Fluconazole Brand Name- Diflucan
What is Fluconazole
Fluconazole is a synthetic antifungal agent of the triazole class. It is administered orally and intravenously.
The antifungal spectrum for fluconazole is broader than that of the imidazole antifungals class, which includes agents such as ketoconazole, miconazole, and clotrimazole.
Fluconazole is more resistant to first-pass metabolism and has lower lipophilicity and protein binding than does ketoconazole. Unlike ketoconazole, the oral absorption of fluconazole is not affected by the absence of stomach acid.
Fluconazole is approved for the treatment of a variety of infections caused by Candida and for the treatment of cryptococcal meningitis.
Additionally, fluconazole is indicated to decrease the incidence of candidiasis in patients undergoing bone marrow transplant who receive chemotherapy and/or radiation therapy.
Fluconazole has been shown equivalent to amphotericin B in the treatment of candidemia in non-neutropenic patients; however, prophylactic use of fluconazole in bone-marrow transplant patients has been associated with increased recovery of C. krusei.
Fluconazole was approved by the FDA in January 1990. In June 1994, a single oral dose of fluconazole was approved for the treatment of vaginal candidiasis.
Indications
- bacterial vaginosis
- Blastomyces dermatitidis
- blastomycosis
- bone and joint infections
- Candida albicans
- Candida glabrata
- Candida guilliermondii
- Candida kefyr
- Candida parapsilosis
- Candida pseudotropicalis
- Candida stellatoidea
- Candida tropicalis
- candidemia
- candidiasis
- candidiasis prophylaxis
- candiduria
- Coccidioides immitis
- coccidioidomycosis
- coccidioidomycosis prophylaxis
- cryptococcal meningitis
- cryptococcosis
- Cryptococcus neoformans
- cystitis
- endocarditis
- endophthalmitis
- esophageal candidiasis
- Histoplasma capsulatum
- histoplasmosis
- histoplasmosis prophylaxis
- infectious arthritis
- intraabdominal abscess
- intraabdominal infections
- leishmaniasis
- meningitis
- oropharyngeal candidiasis (thrush)
- osteomyelitis
- Paracoccidioides brasiliensis
- peritonitis
- pneumonia
- pyelonephritis
- skin and skin structure infections
- Sporothrix schenckii
- sporotrichosis
- surgical infection prophylaxis
- Talaromyces marneffei
- talaromycosis prophylaxis
- urinary tract infection (UTI)
- vulvovaginal candidiasis
- vulvovaginal candidiasis prophylaxis
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- adrenocortical insufficiency
- agranulocytosis
- alopecia
- anaphylactoid reactions
- anemia
- angioedema
- asthenia
- cholestasis
- diarrhea
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- dyspepsia
- elevated hepatic enzymes
- fatigue
- fever
- headache
- hepatic failure
- hepatitis
- hypercholesterolemia
- hyperhidrosis
- hypertriglyceridemia
- hypokalemia
- insomnia
- jaundice
- leukopenia
- malaise
- myalgia
- nausea
- neutropenia
- paresthesias
- pruritus
- QT prolongation
- rash
- renal failure (unspecified)
- seizures
- Stevens-Johnson syndrome
- teratogenesis
- thrombocytopenia
- torsade de pointes
- toxic epidermal necrolysis
- tremor
- vertigo
- vomiting
- xerostomia
Monitoring Parameters
- LFTs
- serum creatinine/BUN
Contraindications
- apheresis
- AV block
- azole antifungals hypersensitivity
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- contraception requirements
- driving or operating machinery
- females
- fever
- geriatric
- heart failure
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- long QT syndrome
- myocardial infarction
- neonates
- pheochromocytoma
- pregnancy
- QT prolongation
- renal failure
- renal impairment
- reproductive risk
- rheumatoid arthritis
- serious rash
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abarelix
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetohexamide
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alprazolam
- Amiloride; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Amprenavir
- Anagrelide
- Apomorphine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Avatrombopag
- Azelastine; Fluticasone
- Azithromycin
- Barbiturates
- Beclomethasone
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzhydrocodone; Acetaminophen
- Betamethasone
- Bicalutamide
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Bosutinib
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Butabarbital
- Caffeine
- Caffeine; Ergotamine
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carvedilol
- Celecoxib
- Ceritinib
- Cevimeline
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Ciclesonide
- Cilostazol
- Cimetidine
- Cinacalcet
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clopidogrel
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Corticosteroids
- Cortisone
- Crizotinib
- Cyclosporine
- Daclatasvir
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Degarelix
- Desflurane
- Desipramine
- Deutetrabenazine
- Dexamethasone
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Disopyramide
- Docetaxel
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dutasteride
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Enflurane
- Entrectinib
- Eplerenone
- Eprosartan; Hydrochlorothiazide, HCTZ
- Erdafitinib
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etonogestrel
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Ezogabine
- Famotidine; Ibuprofen
- Fedratinib
- Felodipine
- Fentanyl
- Fesoterodine
- Fingolimod
- Flecainide
- Flibanserin
- Fludrocortisone
- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- Fluvoxamine
- food
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Goserelin
- Granisetron
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydroxychloroquine
- Hydroxyprogesterone
- Hydroxyzine
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Ibutilide
- Ifosfamide
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Inotuzumab Ozogamicin
- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Lacosamide
- Lamivudine, 3TC; Zidovudine, ZDV
- Lapatinib
- Lefamulin
- Lemborexant
- Lenvatinib
- Lesinurad
- Lesinurad; Allopurinol
- Leuprolide
- Leuprolide; Norethindrone
- Levobupivacaine
- Levofloxacin
- Levomethadyl
- Lidocaine
- Lidocaine; Prilocaine
- Lithium
- Lofexidine
- Lomitapide
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macimorelin
- Maprotiline
- Maraviroc
- Mefenamic Acid
- Mefloquine
- Meglitinides
- Meloxicam
- Meperidine; Promethazine
- Mephobarbital
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Methadone
- Methohexital
- Methylergonovine
- Methylprednisolone
- Methysergide
- Metronidazole
- Midazolam
- Midostaurin
- Mifepristone
- Mirtazapine
- Modafinil
- Mometasone
- Moxifloxacin
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nateglinide
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Osilodrostat
- Osimertinib
- Ospemifene
- Oxaliplatin
- Oxybutynin
- Oxycodone
- Ozanimod
- Paclitaxel
- Paliperidone
- Panobinostat
- Paricalcitol
- Pasireotide
- Pazopanib
- Pemigatinib
- Pentamidine
- Pentobarbital
- Pergolide
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pitolisant
- Posaconazole
- Prednisolone
- Prednisone
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Progesterone
- Promethazine
- Propafenone
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Red Yeast Rice
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rilpivirine
- Rimegepant
- Risperidone
- Ritonavir
- Rivaroxaban
- Romidepsin
- Rosiglitazone
- Ruxolitinib
- Saccharomyces boulardii
- Saquinavir
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Selumetinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Sonidegib
- Sorafenib
- Sotalol
- Sufentanil
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamoxifen
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