Fluconazole

Fluconazole Brand Name- Diflucan

What is Fluconazole

Fluconazole is a synthetic antifungal agent of the triazole class. It is administered orally and intravenously.

The antifungal spectrum for fluconazole is broader than that of the imidazole antifungals class, which includes agents such as ketoconazole, miconazole, and clotrimazole.

Fluconazole is more resistant to first-pass metabolism and has lower lipophilicity and protein binding than does ketoconazole. Unlike ketoconazole, the oral absorption of fluconazole is not affected by the absence of stomach acid.

Fluconazole is approved for the treatment of a variety of infections caused by Candida and for the treatment of cryptococcal meningitis.

Additionally, fluconazole is indicated to decrease the incidence of candidiasis in patients undergoing bone marrow transplant who receive chemotherapy and/or radiation therapy.

Fluconazole has been shown equivalent to amphotericin B in the treatment of candidemia in non-neutropenic patients; however, prophylactic use of fluconazole in bone-marrow transplant patients has been associated with increased recovery of C. krusei.

Fluconazole was approved by the FDA in January 1990. In June 1994, a single oral dose of fluconazole was approved for the treatment of vaginal candidiasis.

Indications

  1. bacterial vaginosis
  2. Blastomyces dermatitidis
  3. blastomycosis
  4. bone and joint infections
  5. Candida albicans
  6. Candida glabrata
  7. Candida guilliermondii
  8. Candida kefyr
  9. Candida parapsilosis
  10. Candida pseudotropicalis
  11. Candida stellatoidea
  12. Candida tropicalis
  13. candidemia
  14. candidiasis
  15. candidiasis prophylaxis
  16. candiduria
  17. Coccidioides immitis
  18. coccidioidomycosis
  19. coccidioidomycosis prophylaxis
  20. cryptococcal meningitis
  21. cryptococcosis
  22. Cryptococcus neoformans
  23. cystitis
  24. endocarditis
  25. endophthalmitis
  26. esophageal candidiasis
  27. Histoplasma capsulatum
  28. histoplasmosis
  29. histoplasmosis prophylaxis
  30. infectious arthritis
  31. intraabdominal abscess
  32. intraabdominal infections
  33. leishmaniasis
  34. meningitis
  35. oropharyngeal candidiasis (thrush)
  36. osteomyelitis
  37. Paracoccidioides brasiliensis
  38. peritonitis
  39. pneumonia
  40. pyelonephritis
  41. skin and skin structure infections
  42. Sporothrix schenckii
  43. sporotrichosis
  44. surgical infection prophylaxis
  45. Talaromyces marneffei
  46. talaromycosis prophylaxis
  47. urinary tract infection (UTI)
  48. vulvovaginal candidiasis
  49. vulvovaginal candidiasis prophylaxis

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. adrenocortical insufficiency
  4. agranulocytosis
  5. alopecia
  6. anaphylactoid reactions
  7. anemia
  8. angioedema
  9. asthenia
  10. cholestasis
  11. diarrhea
  12. dizziness
  13. drowsiness
  14. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  15. dysgeusia
  16. dyspepsia
  17. elevated hepatic enzymes
  18. fatigue
  19. fever
  20. headache
  21. hepatic failure
  22. hepatitis
  23. hypercholesterolemia
  24. hyperhidrosis
  25. hypertriglyceridemia
  26. hypokalemia
  27. insomnia
  28. jaundice
  29. leukopenia
  30. malaise
  31. myalgia
  32. nausea
  33. neutropenia
  34. paresthesias
  35. pruritus
  36. QT prolongation
  37. rash
  38. renal failure (unspecified)
  39. seizures
  40. Stevens-Johnson syndrome
  41. teratogenesis
  42. thrombocytopenia
  43. torsade de pointes
  44. toxic epidermal necrolysis
  45. tremor
  46. vertigo
  47. vomiting
  48. xerostomia

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN

Contraindications

  • apheresis
  • AV block
  • azole antifungals hypersensitivity
  • bradycardia
  • breast-feeding
  • cardiomyopathy
  • celiac disease
  • contraception requirements
  • driving or operating machinery
  • females
  • fever
  • geriatric
  • heart failure
  • hepatic disease
  • human immunodeficiency virus (HIV) infection
  • hyperparathyroidism
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypothermia
  • hypothyroidism
  • long QT syndrome
  • myocardial infarction
  • neonates
  • pheochromocytoma
  • pregnancy
  • QT prolongation
  • renal failure
  • renal impairment
  • reproductive risk
  • rheumatoid arthritis
  • serious rash
  • sickle cell disease
  • sleep deprivation
  • stroke
  • systemic lupus erythematosus (SLE)

Interactions

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