Fingolimod Brand Name– Gilenya
What is Fingolimod
Fingolimod is a sphingosine 1-phosphate receptor modulator.
The drug is indicated for the treatment of adult and pediatric patients 10 years and older with relapsing forms of multiple sclerosis (MS) with relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
The drug reduces the frequency of clinical exacerbations and delays the accumulation of physical disability.
In a year-long comparative study, fewer adult patients who received fingolimod 0.5 mg orally each day as compared with interferon beta-1a 30 mcg IM once weekly had a relapse (17% vs. 30%). The annualized relapse rate was 0.16 for fingolimod recipients and 0.33 for interferon beta-1a recipients.
Hypersensitivity, cardiac or ocular conditions, or severe hepatic disease may preclude treatment with the drug.
Fingolimod was initially approved by the FDA in 2010; pediatric approval was attained in 2018. Financial assistance and other information is available by calling 1-877-408-4974.
Indications
- multiple sclerosis
Side Effects
- abdominal pain
- actinic keratosis
- alopecia
- angioedema
- arthralgia
- asthenia
- atopic dermatitis
- AV block
- back pain
- blurred vision
- bradycardia
- cervical cancer
- cervical dysplasia
- chest pain (unspecified)
- cough
- depression
- diarrhea
- dizziness
- dyspnea
- elevated hepatic enzymes
- encephalopathy
- fatigue
- headache
- hemolytic anemia
- hepatic failure
- hepatitis
- hepatotoxicity
- hyperbilirubinemia
- hypertension
- hypertriglyceridemia
- hypotension
- infection
- influenza
- jaundice
- leukopenia
- lymphoma
- lymphopenia
- macular edema
- migraine
- multiple sclerosis exacerbation
- myalgia
- nausea
- neutropenia
- new primary malignancy
- palpitations
- progressive multifocal leukoencephalopathy
- pruritus
- rash
- seizures
- sinusitis
- skin cancer
- stroke
- syncope
- thrombocytopenia
- urticaria
- visual impairment
Monitoring Parameters
- CBC
- ECG
- LFTs
- ophthalmologic exam
- serum bilirubin
- skin cancer screening exam
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- angina
- apheresis
- asthma
- AV block
- bradycardia
- breast-feeding
- cardiac arrest
- cardiomyopathy
- celiac disease
- cerebrovascular disease
- chemotherapy
- chronic obstructive pulmonary disease (COPD)
- contraception requirements
- corticosteroid therapy
- diabetes mellitus
- encephalopathy
- females
- fever
- fungal infection
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- herpes infection
- history of angioedema
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- immunosuppression
- infection
- jaundice
- leukemia
- long QT syndrome
- lymphoma
- multiple sclerosis exacerbation
- mycobacterial infection
- myocardial infarction
- pheochromocytoma
- pregnancy
- progressive multifocal leukoencephalopathy
- pulmonary disease
- QT prolongation
- reproductive risk
- respiratory insufficiency
- rheumatoid arthritis
- sick sinus syndrome
- sickle cell disease
- skin cancer
- sleep apnea
- sleep deprivation
- stroke
- sunlight (UV) exposure
- syncope
- systemic lupus erythematosus (SLE)
- uveitis
- vaccination
- viral infection
- visual disturbance
Interactions
- Acebutolol
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Azithromycin
- Bedaquiline
- Bendroflumethiazide; Nadolol
- Beta-adrenergic blockers
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bretylium
- Brimonidine; Timolol
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Carteolol
- Carvedilol
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Class IA Antiarrhythmics
- Clofazimine
- Clomipramine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Dasatinib
- Degarelix
- Desipramine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Digoxin
- Diltiazem
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxepin
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esmolol
- Ezogabine
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Halogenated Anesthetics
- Haloperidol
- Histrelin
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Labetalol
- Lapatinib
- Lefamulin
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levofloxacin
- Lithium
- Live Vaccines
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Macimorelin
- Maprotiline
- Mefloquine
- Meperidine; Promethazine
- Metaproterenol
- Methadone
- Metoprolol
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Moxifloxacin
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nilotinib
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Penbutolol
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pindolol
- Pirbuterol
- Pitolisant
- Posaconazole
- Primaquine
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Propranolol
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Romidepsin
- Salmeterol
- Saquinavir
- Selpercatinib
- Sertraline
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Terbutaline
- Tetanus Toxoid
- Tetrabenazine
- Thioridazine
- Timolol
- Tiotropium; Olodaterol
- Tolterodine
- Toremifene
- Trandolapril; Verapamil
- Trazodone
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Verapamil
- Voriconazole
- Vorinostat
- Ziprasidone
