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Filgrastim G CSF Brand Names- Neupogen | Nivestym | Zarxio
What is Filgrastim G CSF
Filgrastim is a leukocyte growth factor that binds to cell surface receptors on hematopoietic cells stimulating proliferation, differentiation, commitment, and end cell functional activation.
It is indicated to increase survival in patients acutely exposed to myelosuppressive doses of radiation. Efficacy for this indication was based on animal data in monkeys.
Filgrastim and the biosimilar products, filgrastim-sndz and filgrastim-aafi, are indicated to reduce the duration of neutropenia and incidence of infection in patients with non-myeloid malignancies or acute myelogenous leukemia receiving myelosuppressive chemotherapy and in patients with non-myeloid malignancies undergoing myeloablative chemotherapy followed by a bone marrow transplant; these products are also indicated for the mobilization of peripheral blood progenitor cells for collection by leukapheresis and for the treatment of severe chronic neutropenia.
Acute respiratory distress syndrome, fatal splenic rupture, and glomerulonephritis have occurred with filgrastim products
Indications
- aplastic anemia
- chemotherapy-induced neutropenia
- ganciclovir-induced neutropenia
- myelodysplastic syndrome (MDS)
- neutropenia
- peripheral blood stem cell (PBSC) mobilization
- radiation exposure
For the treatment of neutropenia
for the treatment of severe chronic congenital neutropenia
Filgrastim has been designated an orphan drug by the FDA for this indication.
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- alopecia
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- antibody formation
- aortitis
- arthralgia
- asthenia
- azotemia
- back pain
- bleeding
- bone pain
- capillary leak syndrome
- chest pain (unspecified)
- constipation
- cough
- diarrhea
- dizziness
- dyspnea
- edema
- epistaxis
- erythema
- fatigue
- fever
- glomerulonephritis
- headache
- hematuria
- hemoptysis
- hypertension
- hypoalbuminemia
- hypoesthesia
- hypotension
- hypoxia
- infection
- insomnia
- leukocytosis
- maculopapular rash
- malaise
- muscle cramps
- musculoskeletal pain
- nausea
- osteoporosis
- peripheral edema
- proteinuria
- rash
- sickle-cell crisis
- splenic rupture
- splenomegaly
- thrombocytopenia
- vasculitis
- vomiting
- wheezing
Monitoring Parameters
- CBC with differential
- platelet count
Contraindications
- breast-feeding
- E. coli protein hypersensitivity
- latex hypersensitivity
- leukemia
- leukocytosis
- obstetric delivery
- pregnancy
- sickle cell disease
- thrombocytopenia
Interactions
- Abemaciclib
- Aldesleukin, IL-2
- Alemtuzumab
- Alpha interferons
- Altretamine
- Antimetabolites
- Bexarotene
- Chlorambucil
- Cladribine
- Clofarabine
- Cyclophosphamide
- Denileukin Diftitox
- Docetaxel
- Estramustine
- Fludarabine
- Ibritumomab Tiuxetan
- Lithium
- Lomustine, CCNU
- Mercaptopurine, 6-MP
- Methotrexate
- Natural Antineoplastics
- Nelarabine
- Paclitaxel
- Pentostatin
- Tositumomab
- Tretinoin, ATRA
