Fenoprofen

Fenoprofen Brand Names- Nalfon | ProFeno

What is Fenoprofen

Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid chemical class.

Fenoprofen possesses antipyretic and analgesic properties and is structurally and pharmacologically related to ibuprofen and naproxen. All NSAIDs including fenoprofen cause an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.

The lowest effective fenoprofen dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.

Fenoprofen is indicated for the symptomatic treatment of rheumatoid arthritis and osteoarthritis, and to alleviate mild to moderate pain. Clinical trials have demonstrated some effectiveness in acute gouty arthritis and ankylosing spondylitis.

Fenoprofen calcium was approved by the FDA in March 1976.

Indications

1. ankylosing spondylitis
2. arthralgia
3. bone pain
4. dental pain
5. fever
6. gouty arthritis
7. headache
8. migraine
9. migraine prophylaxis
10. mild pain
11. moderate pain
12. myalgia
13. osteoarthritis
14. rheumatoid arthritis

For the treatment of osteoarthritis or ankylosing spondylitis

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. anaphylactoid reactions
5. anemia
6. angioedema
7. anorexia
8. anuria
9. aplastic anemia
10. aseptic meningitis
11. asthenia
12. atrial fibrillation
13. azotemia
14. blurred vision
15. confusion
16. constipation
17. cystitis
18. depression
19. diaphoresis
20. diarrhea
21. diplopia
22. dizziness
23. drowsiness
24. dyspepsia
25. dysphagia
26. dyspnea
27. dysuria
28. elevated hepatic enzymes
29. esophageal stricture
30. esophageal ulceration
31. esophagitis
32. exfoliative dermatitis
33. fatigue
34. fever
35. flatulence
36. gastritis
37. GI bleeding
38. GI perforation
39. headache
40. hearing loss
41. heart failure
42. hematoma
43. hematuria
44. hemolytic anemia
45. hepatic failure
46. hepatic necrosis
47. hepatitis
48. hypertension
49. hyponatremia
50. infection
51. insomnia
52. interstitial nephritis
53. jaundice
54. lymphadenopathy
55. malaise
56. mastalgia
57. melena
58. metallic taste
59. myocardial infarction
60. nausea
61. odynophagia
62. oliguria
63. optic neuritis
64. palpitations
65. pancreatitis
66. pancytopenia
67. peptic ulcer
68. peripheral edema
69. pharyngitis
70. platelet dysfunction
71. prolonged bleeding time
72. pruritus
73. pulmonary edema
74. purpura
75. pyrosis (heartburn)
76. rash
77. renal failure (unspecified)
78. renal papillary necrosis
79. seizures
80. sinus tachycardia
81. Stevens-Johnson syndrome
82. stroke
83. supraventricular tachycardia (SVT)
84. thrombocytopenia
85. thromboembolism
86. tinnitus
87. toxic epidermal necrolysis
88. tremor
89. urticaria
90. vomiting
91. xerostomia

Monitoring Parameters

• CBC
• LFTs
• serum creatinine/BUN
• stool guaiac

Contraindications

• acute bronchospasm
• acute myocardial infarction
• alcoholism
• anemia
• angina
• anticoagulant therapy
• asthma
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• chemotherapy
• coagulopathy
• coronary artery bypass graft surgery (CABG)
• coronary artery disease
• corticosteroid therapy
• dental disease
• dental work
• diabetes mellitus
• edema
• geriatric
• GI bleeding
• GI disease
• GI perforation
• heart failure
• hematological disease
• hemophilia
• hepatic disease
• hypertension
• immunosuppression
• infertility
• intramuscular injections
• jaundice
• labor
• myocardial infarction
• nasal polyps
• neutropenia
• NSAID hypersensitivity
• obstetric delivery
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• renal disease
• renal failure
• renal impairment
• reproductive risk
• rheumatoid arthritis
• salicylate hypersensitivity
• stroke
• surgery
• systemic lupus erythematosus (SLE)
• tachycardia
• thrombocytopenia
• thromboembolism
• tobacco smoking
• ulcerative colitis
• urticaria

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