Fenofibrate

Fenofibrate Brand Names

Antara | Fenoglide | Lipofen | Lofibra | Tricor | Triglide

What is Fenofibrate

Fenofibrate is an oral antilipemic agent. It is a fibric acid derivative; other members of this drug class include clofibrate, and gemfibrozil.

Fenofibrate is a prodrug that is hydrolyzed to fenofibric acid. Like the other ‘fibrates’, fenofibrate is most effective in treating lipid disorders associated with very high elevations of serum triglycerides and VLDL (e.g., type IV and V hyperlipoproteinemias).

On average, 30% reductions in triglyceride concentrations are achieved with fenofibrate doses of 201 mg per day.

Fenofibrate appears to reduce LDL cholesterol to a greater extent than gemfibrozil, but confirmation from comparative clinical trials will be needed. Efficacy in reducing LDL and total cholesterol levels has been less than HMG-CoA reductase inhibitors; however, fenofibrate is indicated for primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb).

Indications

• hypercholesterolemia
• hypertriglyceridemia

For use as an adjunct to diet for the treatment of adult patients with severe hypertriglyceridemia

Side Effects

1. abdominal pain
2. acne vulgaris
3. agranulocytosis
4. alopecia
5. amblyopia
6. anemia
7. angina
8. angioedema
9. anorexia
10. anxiety
11. appetite stimulation
12. arrhythmia exacerbation
13. arthralgia
14. asthenia
15. atrial fibrillation
16. back pain
17. bleeding
18. blurred vision
19. bronchospasm
20. candidiasis
21. cataracts
22. chest pain (unspecified)
23. cholecystitis
24. cholelithiasis
25. cirrhosis
26. colitis
27. conjunctivitis
28. constipation
29. contact dermatitis
30. cough
31. cystitis
32. decreased HDL cholesterol (HDL-C) concentration
33. depression
34. diabetes mellitus
35. diaphoresis
36. diarrhea
37. dizziness
38. drowsiness
39. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
40. dyspepsia
41. dyspnea
42. dysuria
43. ecchymosis
44. edema
45. elevated hepatic enzymes
46. eosinophilia
47. eructation
48. esophagitis
49. fever
50. flatulence
51. gastritis
52. gout
53. gynecomastia
54. headache
55. hepatitis
56. hypertension
57. hypertonia
58. hyperuricemia
59. hypoglycemia
60. hypotension
61. increased urinary frequency
62. infection
63. insomnia
64. interstitial lung disease
65. jaundice
66. laryngitis
67. leukopenia
68. libido decrease
69. lymphadenopathy
70. maculopapular rash
71. malaise
72. migraine
73. muscle cramps
74. musculoskeletal pain
75. myalgia
76. myasthenia
77. myocardial infarction
78. myopathy
79. nausea
80. nephrolithiasis
81. palpitations
82. pancreatitis
83. paresthesias
84. peptic ulcer
85. peripheral edema
86. pharyngitis
87. phlebitis
88. photosensitivity
89. pruritus
90. pulmonary embolism
91. rash
92. rhabdomyolysis
93. rhinitis
94. serious hypersensitivity reactions or anaphylaxis
95. sinus tachycardia
96. sinusitis
97. skin irritation
98. skin ulcer
99. Stevens-Johnson syndrome
100. thrombocytopenia
101. thrombosis
102. toxic epidermal necrolysis
103. urticaria
104. vertigo
105. vitamin B12 deficiency
106. vomiting
107. weakness
108. weight gain
109. weight loss
110. xerostomia

Monitoring Parameters

• CBC with differential
• creatine phosphokinase (CPK)
• LFTs
• serum bilirubin (total and direct)
• serum cholesterol profile
• serum triglycerides

Contraindications

• anticoagulant therapy
• biliary cirrhosis
• breast-feeding
• cardiac disease
• cholelithiasis
• diabetes mellitus
• dialysis
• gallbladder disease
• geriatric
• hepatic disease
• hypothyroidism
• pregnancy
• renal disease
• renal failure
• renal impairment
• thromboembolic disease

Interactions

• Acarbose
• Albiglutide
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Amlodipine; Atorvastatin
• Amoxicillin; Clarithromycin; Omeprazole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Pravastatin
• Atorvastatin
• Atorvastatin; Ezetimibe
• Bempedoic Acid; Ezetimibe
• Canagliflozin
• Canagliflozin; Metformin
• Cannabidiol
• Chenodiol
• Cholestyramine
• Colchicine
• Colchicine; Probenecid
• Colestipol
• Cyclosporine
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Dipeptidyl Peptidase-4 Inhibitors
• Dulaglutide
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Exenatide
• Ezetimibe
• Ezetimibe; Simvastatin
• Fluvastatin
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Incretin Mimetics
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Ixabepilone
• Linagliptin; Metformin
• Liraglutide
• Lixisenatide
• Lovastatin
• Lovastatin; Niacin
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Miglitol
• Nateglinide
• Niacin; Simvastatin
• Omeprazole
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Paclitaxel
• Pioglitazone
• Pitavastatin
• Pramlintide
• Pravastatin
• Raltegravir
• Red Yeast Rice
• Repaglinide
• Rosiglitazone
• Rosuvastatin
• Semaglutide
• SGLT2 Inhibitors
• Simvastatin
• Simvastatin; Sitagliptin
• Sulfonylureas
• Tacrolimus
• Telbivudine
• Ursodeoxycholic Acid, Ursodiol
• Warfarin