Fedratinib Brand Name– INREBIC
What is Fedratinib
Fedratinib is a Janus associated kinase-2 (JAK2) and FMS-like tyrosine kinase-3 (FLT3) inhibitor approved for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis.
Fedratinib labeling has a boxed warning for encephalopathy, including Wernicke encephalopathy; thiamine deficiency should be evaluated and corrected prior to treatment initiation
Indications
- myelofibrosis
For the treatment of intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis
NOTE: The FDA has designated fedratinib as an orphan drug for the treatment of primary or secondary myelofibrosis.
Side Effects
- anemia
- anemia
- angina
- asthenia
- asthenia
- ataxia
- bleeding
- bone pain
- confusion
- constipation
- cystitis
- diarrhea
- diarrhea
- diplopia
- dizziness
- dysuria
- ecchymosis
- elevated hepatic enzymes
- elevated hepatic enzymes
- encephalopathy
- fatigue
- fatigue
- headache
- heart failure
- hepatotoxicity
- hyperamylasemia
- hyperamylasemia
- hypertension
- hypertension
- hyponatremia
- hyponatremia
- infection
- memory impairment
- muscle cramps
- musculoskeletal pain
- nausea
- nephrotoxicity
- neutropenia
- neutropenia
- nystagmus
- pancreatitis
- thrombocytopenia
- thrombocytopenia
- vomiting
- vomiting
- weight gain
Monitoring Parameters
- CBC
- LFTs
- serum amylase
- serum creatinine/BUN
- serum lipase
- serum vitamin B1 (thiamine) concentrations
Contraindications
- anemia
- breast-feeding
- children
- diarrhea
- encephalopathy
- hepatic disease
- hepatotoxicity
- infants
- nausea/vomiting
- neutropenia
- pancreatitis
- pregnancy
- renal failure
- renal impairment
- thiamine deficiency
- thrombocytopenia
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atovaquone; Proguanil
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Bexarotene
- Bosentan
- Bosutinib
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Caffeine; Ergotamine
- Cannabidiol
- Carbamazepine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carisoprodol
- Cenobamate
- Ceritinib
- Cevimeline
- Chloramphenicol
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Cimetidine
- Cisapride
- Citalopram
- Clarithromycin
- Clobazam
- Clomipramine
- Clonazepam
- Clopidogrel
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens; Medroxyprogesterone
- Crizotinib
- Cyclosporine
- Dabrafenib
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Desipramine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dofetilide
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doxepin
- Doxorubicin
- Dronabinol
- Dronedarone
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Entrectinib
- Enzalutamide
- Eplerenone
- Ergotamine
- Eslicarbazepine
- Esomeprazole
- Esomeprazole; Naproxen
- Estradiol Cypionate; Medroxyprogesterone
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Felodipine
- Fentanyl
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Gefitinib
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Imipramine
- Indinavir
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Lefamulin
- Lemborexant
- Lofexidine
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Maprotiline
- Medroxyprogesterone
- Metformin; Repaglinide
- Methadone
- Methohexital
- Metoprolol
- Mexiletine
- Midazolam
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Neratinib
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nortriptyline
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oxybutynin
- Oxycodone
- Paclitaxel
- Pemigatinib
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenytoin
- Pimozide
- Posaconazole
- Primidone
- Propafenone
- Propranolol
- Protriptyline
- Quinine
- Ranolazine
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rilpivirine
- Rimegepant
- Ritonavir
- Roflumilast
- Rucaparib
- Saquinavir
- Secobarbital
- Selpercatinib
- Selumetinib
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Suvorexant
- Tacrolimus
- Tamsulosin
- Tazemetostat
- Telithromycin
- Terbinafine
- Tezacaftor; Ivacaftor
- Thioridazine
- Ticagrelor
- Tinidazole
- Tipranavir
- Tolvaptan
- Tramadol
- Trandolapril; Verapamil
- Triazolam
- Trimipramine
- Tucatinib
- Ubrogepant
- Vardenafil
- Venetoclax
- Venlafaxine
- Verapamil
- Vinblastine
- Vinorelbine
- Voriconazole
- Warfarin
- Zanubrutinib
- Zolpidem
