Ezogabine Brand Name– Potiga
What is Ezogabine
Ezogabine is an oral anticonvulsant agent which is a potassium channel opener; additional pharmacologic actions are potentially mediated through augmentation of GABA.
Efficacy was established in clinical trials which enrolled patients with partial onset seizures with or without secondary generalization and who were not controlled with 1 to 3 antiepileptic drugs (AEDs).
Retinal abnormalities with potential for an accompanying decrease in visual acuity have been reported in patients in long-term clinical trials of ezogabine.
Therefore, the use of ezogabine should be reserved for patients who have had an inadequate response to several alternative treatments and for whom the benefits outweigh the potential risk of vision loss.
Ezogabine was FDA-approved in June 2011.
Indications
- partial seizures
For the adjunct treatment of partial seizures in patients who have had an inadequate response to several alternative treatments and for whom the potential benefits outweigh the risk of retinal abnormalities and potential decline in visual acuity
Side Effects
- alopecia
- amnesia
- anxiety
- aphasia
- appetite stimulation
- asthenia
- blurred vision
- coma
- confusion
- constipation
- depression
- diplopia
- dizziness
- drowsiness
- dysarthria
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- elevated hepatic enzymes
- emotional lability
- encephalopathy
- euphoria
- fatigue
- flank pain
- hallucinations
- hematuria
- hyperhidrosis
- influenza
- leukopenia
- malaise
- memory impairment
- myoclonia
- nausea
- nephrolithiasis
- neutropenia
- nystagmus
- paresthesias
- peripheral edema
- psychosis
- QT prolongation
- rash
- retinal pigment changes
- skin discoloration
- suicidal ideation
- syncope
- thrombocytopenia
- tremor
- urinary retention
- vertigo
- visual impairment
- weight gain
- xerostomia
Monitoring Parameters
- LFTs
- ophthalmologic exam
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- apheresis
- AV block
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- children
- dementia
- depression
- dialysis
- driving or operating machinery
- females
- fever
- geriatric
- heart failure
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infants
- long QT syndrome
- myocardial infarction
- neonates
- pheochromocytoma
- pregnancy
- prostatic hypertrophy
- psychosis
- QT prolongation
- renal failure
- renal impairment
- rheumatoid arthritis
- schizophrenia
- sickle cell disease
- sleep deprivation
- stroke
- substance abuse
- suicidal ideation
- systemic lupus erythematosus (SLE)
- urinary retention
- visual impairment
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amantadine
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Anagrelide
- Anticholinergics
- Anxiolytics; Sedatives; and Hypnotics
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atomoxetine
- Azithromycin
- Bedaquiline
- Benzphetamine
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Butorphanol
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Ceritinib
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- Chloroquine
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- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
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