Etravirine Brand Name– Intelence
What is Etravirine
Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus (HIV).
It is indicated for use with other antiretroviral medications to treat HIV-1 infections in treatment-experienced adult and pediatric patients 2 years of age and older.
Etravirine must be administered after a meal to improve absorption. Its use is associated with severe and potentially life-threatening rashes. Such rashes occur most commonly during the first 6 weeks of therapy.
Mild to moderate rashes usually resolve within 1 to 2 weeks of continued treatment; severe rashes warrant discontinuation of therapy
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
- human immunodeficiency virus (HIV) prophylaxis
Side Effects
- abnormal dreams
- amnesia
- anemia
- angina
- angioedema
- anorexia
- anxiety
- atrial fibrillation
- blurred vision
- bronchospasm
- confusion
- conjunctivitis
- constipation
- Cushingoid features
- diabetes mellitus
- diarrhea
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspnea
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fever
- flatulence
- gastritis
- gastroesophageal reflux
- gynecomastia
- hematemesis
- hemolytic anemia
- hepatic failure
- hepatitis
- hepatomegaly
- hyperamylasemia
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hyperhidrosis
- hyperlipidemia
- hypertriglyceridemia
- hypoesthesia
- leukopenia
- lipodystrophy
- maculopapular rash
- malaise
- musculoskeletal pain
- myocardial infarction
- neutropenia
- night sweats
- nightmares
- oral ulceration
- pancreatitis
- paresthesias
- peripheral neuropathy
- rash
- renal failure (unspecified)
- rhabdomyolysis
- seizures
- steatosis
- Stevens-Johnson syndrome
- stomatitis
- stroke
- syncope
- thrombocytopenia
- toxic epidermal necrolysis
- tremor
- vertigo
- xerosis
- xerostomia
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum lipid profile
- urinalysis
Contraindications
- autoimmune disease
- breast-feeding
- females
- geriatric
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis
- hepatitis B and HIV coinfection
- hepatitis C and HIV coinfection
- human immunodeficiency virus (HIV) infection resistance
- hypercholesterolemia
- hyperlipidemia
- hypertriglyceridemia
- immune reconstitution syndrome
- pregnancy
- serious rash
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Adefovir
- Afatinib
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Axitinib
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Betrixaban
- Boceprevir
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Cannabidiol
- Capmatinib
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carvedilol
- Ceritinib
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Citalopram
- Clarithromycin
- Clobazam
- Clopidogrel
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Crizotinib
- Cyclosporine
- Dabigatran
- Daclatasvir
- Dapsone
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Dexamethasone
- Dextromethorphan; Quinidine
- Diazepam
- Diclofenac
- Diclofenac; Misoprostol
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Docetaxel
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxorubicin
- Dronabinol
- Dronedarone
- Duvelisib
- Echinacea
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Eletriptan
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Encorafenib
- Entrectinib
- Enzalutamide
- Erdafitinib
- Erlotinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Ezetimibe; Simvastatin
- Fedratinib
- Fenofibric Acid
- Fentanyl
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Flecainide
- Flibanserin
- Fluconazole
- Fluvastatin
- food
- Fosamprenavir
- Fosphenytoin
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glyburide
- Glyburide; Metformin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Imatinib
- Indinavir
- Interferon Alfa-2b; Ribavirin
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivabradine
- Ketoconazole
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lapatinib
- Lefamulin
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Luliconazole
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macimorelin
- Maraviroc
- Mefloquine
- Meloxicam
- Methadone
- Methylprednisolone
- Mexiletine
- Mitomycin
- Mitotane
- Morphine
- Morphine; Naltrexone
- Nanoparticle Albumin-Bound Paclitaxel
- Nelfinavir
- Neratinib
- Nevirapine
- Niacin; Simvastatin
- Nisoldipine
- Nortriptyline
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Orlistat
- Oxycodone
- Paclitaxel
- Pazopanib
- Pemigatinib
- Perampanel
- Perindopril; Amlodipine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Posaconazole
- Pravastatin
- Praziquantel
- Prednisone
- Primidone
- Propafenone
- Quinidine
- Quinine
- Raltegravir
- Ranolazine
- Ribavirin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rilpivirine
- Rimegepant
- Ritonavir
- Rivaroxaban
- Roflumilast
- Romidepsin
- Rosuvastatin
- Ruxolitinib
- Sacituzumab Govitecan
- Saquinavir
- Selpercatinib
- Selumetinib
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Somatropin, rh-GH
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sunitinib
- Tacrolimus
- Tadalafil
- Talazoparib
- Tasimelteon
- Tazemetostat
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Teniposide
- Tenofovir, PMPA
- Terbinafine
- Ticagrelor
- Tipranavir
- Tolvaptan
- Topotecan
- Toremifene
- Trandolapril; Verapamil
- Tucatinib
- Ubrogepant
- Ulipristal
- Vemurafenib
- Venetoclax
- Verapamil
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Voxelotor
- Warfarin
- Zanubrutinib
- Zolpidem
