Ethiodized Oil Brand Name– Lipiodol
What is Ethiodized Oil
Ethiodized oil is an injectable poppy seed oil-based, iodinated radiopaque contrast agent indicated for hysterosalpingography, lymphography, and selective hepatic intra-arterial use for imaging tumors in patients with known hepatocellular carcinoma (HCC).
Ethiodized oil is for intrauterine, intralymphatic, and selective hepatic intra-arterial use only. Pulmonary embolism may occur immediately or after a few hours to days from inadvertent intravascular administration or intravasation of ethiodized oil and cause decreased pulmonary diffusing capacity and pulmonary blood flow, pulmonary infarction, acute respiratory distress syndrome (ARDS), and fatalities.
To minimize the risk of pulmonary embolism, slow injection with radiologic monitoring is necessary during ethiodized oil administration. Also, iodinated contrast media, such as ethiodized oil, can affect thyroid function and may cause hyperthyroidism or hypothyroidism.
Ethiodized oil may remain in the body for several months, depending on dose administered and route of administration; thyroid function monitoring for several months after ethiodized oil administration may be considered.
Indications
- hysterosalpingography
- lymphography
- radiographic examination
For use as contrast during hysterosalpingography
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anaphylactoid reactions
- cough
- dyspnea
- edema
- fever
- foreign body sensation
- headache
- hepatic decompensation
- hyperthyroidism
- hypothyroidism
- impaired wound healing
- nausea
- phlebitis
- pulmonary embolism
- rash
- retinal thrombosis
- stroke
- thrombosis
- vomiting
Monitoring Parameters
- pregnancy testing
- serum creatinine/BUN
- thyroid function tests (TFTs)
Contraindications
- asthma
- bleeding
- breast-feeding
- cervicitis
- dysfunctional uterine bleeding
- hepatic disease
- hyperthyroidism
- intravenous administration
- neoplastic disease
- pregnancy
- pregnancy testing
- pulmonary disease
- radiation therapy
- radiopaque contrast media hypersensitivity
- renal impairment
- reproductive risk
- surgery
- trauma
Interactions
- Sodium Iodide
Sodium Iodide: (Moderate) Ethiodized oil may impair visualization of thyroid scintigraphy and reduce effectiveness of sodium iodide I-131 treatment for several weeks to months after ethiodized oil administration. Ethiodized oil interferes with radioactive iodine uptake by the thyroid.
