Ethinyl Estradiol Norethindrone Acetate Ferrous fumarate

Ethinyl Estradiol Norethindrone Acetate Ferrous fumarate Brand Names

Aurovela 24 Fe 1/20 | Aurovela Fe | Blisovi 24 Fe | Blisovi Fe | Charlotte 24 Fe | Estrostep Fe | Gildess 24 Fe | Gildess Fe 1.5/30 | Gildess Fe 1/20 | Hailey 24 Fe | Hailey Fe 1.5/30 | Junel Fe 1.5/30 | Junel Fe 1/20 | Junel Fe 24 | Larin Fe | Lo Loestrin Fe | Lo Minastrin Fe | Loestrin 24 Fe | Loestrin FE 1.5/30 | Loestrin FE 1/20 | Lomedia 24 Fe | Melodetta | Mibelas 24 Fe | Microgestin 24 Fe | Microgestin Fe 1.5/30 | Microgestin Fe 1/20 | Minastrin | Tarina 24 Fe | Tarina Fe 1/20 | Taytulla | Tilia Fe | Tri-Legest Fe

What is Ethinyl Estradiol Norethindrone Acetate Ferrous fumarate

Ethinyl estradiol and norethindrone acetate are used together as an oral contraceptive; the ferrous fumarate component does not serve any therapeutic purpose other than to add a small amount of iron replacement during menses. Ethinyl estradiol is a potent, synthetic estrogen.

Norethindrone acetate is a first generation oral progestin with moderate androgenic and slight estrogenic activity relative to newer progestins.

Norethindrone acetate is known as norethisterone acetate outside of the United States.

Combined hormonal contraceptives can be used in female patients from menarche to over the age of 40 years and up until the time of menopause with the proper selection of products.

The choice of a routine hormonal contraceptive for any given patient is based on the individual’s contraceptive needs, underlying medical conditions or risk factors for adverse effects, and individual preferences for use.

All combined oral contraceptives (COCs) have risks related to venous and arterial thromboembolism, particularly in women who smoke; all combined hormonal contraceptive labels contain a boxed warning about tobacco smoking.

The Centers for Disease Control’s U.S. Medical Eligibility Criteria describe considerations for risk vs. benefits, including medical conditions or attributes that contraindicate use; these criteria can help prescribing practitioners in product selection for individual patients.

Ethinyl estradiol/norethindrone acetate with ferrous fumarate oral contraceptive preparations vary in estrogen and/or progestin concentration, available dosage forms (oral tablets vs. chewable tablets), as well as phasic dosing regimens.

Some triphasic products help reduce estrogen-related side effects, such as nausea, fluid retention, and headache) by more closely mimicking a woman’s natural menstrual cycle by providing increasing amounts of estrogen with a constant progestin dose in each phase.

Other products provide low-estrogen dose options; some of these products result in shorter, lighter menstruation cycles.

Ethinyl estradiol/norethindrone acetate oral contraceptives were first approved by the FDA prior to 1982; some products have been additionally FDA-approved for the treatment of acne in adolescent and premenopausal adult females.

Indications

1. acne vulgaris
2. amenorrhea
3. contraception
4. dysfunctional uterine bleeding
5. endometriosis
6. hirsutism
7. polycystic ovary syndrome

Side Effects

1. abdominal pain
2. acne vulgaris
3. alopecia
4. amenorrhea
5. anaphylactoid reactions
6. angioedema
7. anorexia
8. anxiety
9. appetite stimulation
10. arthralgia
11. asthenia
12. back pain
13. bowel ischemia
14. breakthrough bleeding
15. breast discharge
16. breast enlargement
17. candidiasis
18. cataracts
19. cervical dysplasia
20. chest pain (unspecified)
21. cholecystitis
22. cholelithiasis
23. cholestasis
24. colitis
25. cystitis
26. depression
27. diarrhea
28. diplopia
29. dizziness
30. dysmenorrhea
31. dyspepsia
32. edema
33. elevated hepatic enzymes
34. emotional lability
35. erythema multiforme
36. erythema nodosum
37. fatigue
38. fluid retention
39. galactorrhea
40. gingivitis
41. headache
42. hepatitis
43. hepatoma
44. hirsutism
45. hyperlipidemia
46. hypertension
47. hypertriglyceridemia
48. insomnia
49. intracranial bleeding
50. irritability
51. jaundice
52. lactation suppression
53. leukorrhea
54. libido decrease
55. libido increase
56. lupus-like symptoms
57. maculopapular rash
58. malaise
59. mastalgia
60. melasma
61. menorrhagia
62. menstrual irregularity
63. migraine
64. musculoskeletal pain
65. myalgia
66. myocardial infarction
67. nausea
68. new primary malignancy
69. optic neuritis
70. palpitations
71. pancreatitis
72. papilledema
73. peliosis hepatis
74. pelvic pain
75. peripheral edema
76. photosensitivity
77. porphyria
78. pruritus
79. pulmonary embolism
80. rash
81. retinal thrombosis
82. rhinitis
83. sinus tachycardia
84. sinusitis
85. stroke
86. suicidal ideation
87. thromboembolism
88. thrombosis
89. urticaria
90. vaginal discharge
91. vaginal irritation
92. vaginitis
93. visual impairment
94. vomiting
95. weight gain
96. weight loss

Monitoring Parameters

• pap smear
• pelvic exam

Contraindications

• acquired immunodeficiency syndrome (AIDS)
• asthma
• atrial fibrillation
• breast cancer
• breast-feeding
• cerebrovascular disease
• cervical cancer
• children
• chloasma
• contact lenses
• coronary artery disease
• coronary thrombosis
• depression
• diabetes mellitus
• endocarditis
• endometrial cancer
• gallbladder disease
• glaucoma
• headache
• hepatic disease
• hepatitis
• hepatocellular cancer
• hereditary angioedema
• history of angioedema
• human immunodeficiency virus (HIV) infection
• hypercalcemia
• hypercholesterolemia
• hyperlipidemia
• hyperlipoproteinemia
• hypertension
• hypertriglyceridemia
• hypocalcemia
• hypothyroidism
• infants
• jaundice
• migraine
• myocardial infarction
• neonates
• obesity
• obstetric delivery
• ovarian cancer
• pancreatitis
• porphyria
• pregnancy
• protein C deficiency
• protein S deficiency
• renal disease
• seizure disorder
• stroke
• surgery
• systemic lupus erythematosus (SLE)
• thromboembolic disease
• thromboembolism
• thrombophlebitis
• thyroid disease
• tobacco smoking
• uterine cancer
• vaginal bleeding
• vaginal cancer
• valvular heart disease
• visual disturbance

Interactions

• Abacavir; Dolutegravir; Lamivudine
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