Ergotamine Brand Name– Ergomar
What is Ergotamine
Ergotamine is an ergot alkaloid administered to relieve migraine headaches; the drug is roughly 70% effective in controlling acute migraine attacks.
Ergotamine is more effective if taken early in the course of the migraine. Prolonged use or excessive dosage of ergot alkaloids can lead to ergotism, dependence, and/or rebound headaches.
Ergotamine should be prescribed in strict accordance with manufacturer guidelines. Maximum daily and weekly dosage limits should not be exceeded.
Ergotamine was first used medically to treat migraine in the 1920’s, and was approved by the FDA in 1960.
An inhalational form, Medihaler Ergotamine(TM), was available before 1992 from 3M Pharmaceuticals and is no longer marketed in the US.
Injectable formulations are only available outside of the US.
Indications
- headache
- migraine
For the treatment of acute migraine or vascular headache
Side Effects
- abdominal pain
- angina
- bowel ischemia
- bradycardia
- cardiac valvulopathy
- chest pain (unspecified)
- colitis
- coronary vasospasm
- cyanosis
- diarrhea
- edema
- fetal death
- headache
- hypertension
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- paresthesias
- peripheral vasoconstriction
- physiological dependence
- pruritus
- pulmonary fibrosis
- renal tubular necrosis
- retroperitoneal fibrosis
- sinus tachycardia
- spontaneous fetal abortion
- tissue necrosis
- urticaria
- uterine contractions
- vertigo
- vomiting
- weakness
- withdrawal
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- angina
- arteriosclerosis
- basilar/hemiplegic migraine
- biliary tract disease
- breast-feeding
- cardiac disease
- children
- cholestasis
- coronary artery disease
- diabetes mellitus
- eclampsia
- ergot alkaloid hypersensitivity
- geriatric
- hepatic disease
- hypercholesterolemia
- hypertension
- infants
- labor
- malnutrition
- myocardial infarction
- obesity
- obstetric delivery
- peripheral vascular disease
- peripheral vasoconstriction or ischemia
- preeclampsia
- pregnancy
- pulmonary disease
- pulmonary fibrosis
- Raynaud’s phenomenon
- renal disease
- renal failure
- renal impairment
- retroperitoneal fibrosis
- sepsis
- stroke
- surgery
- thromboangiitis obliterans (Buerger’s disease)
- thrombophlebitis
- tobacco smoking
- valvular heart disease
Interactions
- Acebutolol
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alprazolam
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Aprepitant, Fosaprepitant
- Articaine; Epinephrine
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Azithromycin
- Bendroflumethiazide; Nadolol
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bosentan
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Cabergoline
- Canakinumab
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Pseudoephedrine
- Carteolol
- Carvedilol
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloroprocaine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Cimetidine
- Citalopram
- Clarithromycin
- Clofazimine
- Cobicistat
- Cocaine
- Conivaptan
- Crizotinib
- Danazol
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Delavirdine
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diazoxide
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dirithromycin
- Dobutamine
- Dorzolamide; Timolol
- Dronedarone
- Duloxetine
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emapalumab
- Enzalutamide
- Epinephrine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esmolol
- Everolimus
- Fedratinib
- Fenoldopam
- Fexofenadine; Pseudoephedrine
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Fostamatinib
- Frovatriptan
- Glycerol Phenylbutyrate
- grapefruit juice
- Green Tea
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Imatinib
- Isavuconazonium
- Isoproterenol
- Istradefylline
- Itraconazole
- Ivacaftor
- Ketoconazole
- Labetalol
- Lanreotide
- Lapatinib
- Larotrectinib
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobetaxolol
- Levobunolol
- Levomilnacipran
- Lidocaine; Prilocaine
- Linezolid
- Lisdexamfetamine
- Loratadine; Pseudoephedrine
- Lorcaserin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mepivacaine
- Mepivacaine; Levonordefrin
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Metoprolol
- Metronidazole
- Miconazole
- Mifepristone
- Milnacipran
- Minoxidil
- Mirtazapine
- Mitotane
- Nadolol
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nicardipine
- Nicotine
- Nilotinib
- Nitrates
- Nitroprusside
- Norfloxacin
- Oritavancin
- Palbociclib
- Paroxetine
- Pazopanib
- Penbutolol
- Perindopril; Amlodipine
- Phentermine
- Phentermine; Topiramate
- Pindolol
- Posaconazole
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rizatriptan
- Rucaparib
- Rufinamide
- Sarilumab
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Siltuximab
- Simeprevir
- Sotalol
- Streptogramins
- Sumatriptan
- Tedizolid
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Tezacaftor; Ivacaftor
- Timolol
- tobacco
- Tocilizumab
- Trandolapril; Verapamil
- Tucatinib
- Vasopressors
- Vemurafenib
- Venlafaxine
- Verapamil
- Vilazodone
- Voriconazole
- Vortioxetine
- Zafirlukast
- Zileuton
- Zolmitriptan
