Eravacycline Brand Name– XERAVA
What is Eravacycline
Eravacycline is an intravenous, fully synthetic fluorocycline antibiotic within the tetracycline class indicated for the treatment of complicated intraabdominal infections in adults.
It is structurally similar to tetracycline class antibacterial agents. Eravacycline has shown activity against organisms expressing tetracycline-specific resistance mechanisms, including efflux and ribosomal protection.
Like other tetracycline class antibacterial drugs, eravacycline may cause discoloration of deciduous teeth and reversible inhibition of bone growth when administered during the second and third trimester of pregnancy.
Indications
- Bacteroides caccae
- Bacteroides fragilis
- Bacteroides ovatus
- Bacteroides thetaiotaomicron
- Bacteroides uniformis
- Bacteroides vulgatus
- Citrobacter freundii
- Citrobacter koseri
- Clostridium perfringens
- Enterobacter cloacae
- Enterococcus faecalis
- Enterococcus faecium
- Escherichia coli
- intraabdominal infections
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Parabacteroides distasonis
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Streptococcus anginosus
- Streptococcus salivarius
Side Effects
- anaphylactoid reactions
- anxiety
- azotemia
- blurred vision
- chest pain (unspecified)
- depression
- diarrhea
- diplopia
- dizziness
- dysgeusia
- dyspnea
- elevated hepatic enzymes
- enamel hypoplasia
- erythema
- headache
- hyperhidrosis
- hyperphosphatemia
- hypocalcemia
- hypoesthesia
- hypotension
- increased intracranial pressure
- injection site reaction
- insomnia
- nausea
- neutropenia
- onycholysis
- palpitations
- pancreatitis
- papilledema
- paresthesias
- phlebitis
- photosensitivity
- pleural effusion
- pseudomembranous colitis
- pseudotumor cerebri
- rash
- superinfection
- thrombosis
- tooth discoloration
- visual impairment
- vomiting
- wound dehiscence
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- children
- colitis
- diarrhea
- geriatric
- GI disease
- hepatic disease
- increased intracranial pressure
- infants
- inflammatory bowel disease
- neonates
- papilledema
- pregnancy
- pseudomembranous colitis
- sunlight (UV) exposure
- tetracyclines hypersensitivity
- ulcerative colitis
Interactions
- Acetohexamide
- Acitretin
- Aminolevulinic Acid
- Apalutamide
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Carbamazepine
- Chlorpropamide
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Enzalutamide
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Fosphenytoin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isotretinoin
- Leuprolide; Norethindrone
- Levonorgestrel
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mestranol; Norethindrone
- Methoxsalen
- Mitotane
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Phenobarbital
- Phenytoin
- Photosensitizing agents (topical)
- Porfimer
- Primidone
- Rifampin
- Segesterone Acetate; Ethinyl Estradiol
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- St. John’s Wort, Hypericum perforatum
- Sulfonylureas
- Tolazamide
- Tolbutamide
- Tretinoin, ATRA
- Verteporfin
