Epoprostenol

Epoprostenol Brand Names- Flolan | Veletri

What is Epoprostenol

Epoprostenol is the pharmaceutical form of a naturally-occurring prostaglandin commonly referred to as prostacyclin (other names include prostaglandin I₂, PGI₂, prostaglandin X, PGX). Analogs of prostacyclin (e.g., iloprost, treprostinil), have also been developed.

Epoprostenol (prostacyclin) is a vasodilator and an inhibitor of platelet aggregation.

Its major use is for the long-term treatment of primary pulmonary hypertension (PPH) where it improves symptoms and prolongs survival. Intravenous epoprostenol has been reported to significantly improve long-term survival over 3 years for PPH patients compared to historical data.

Epoprostenol has been investigated for use in ischemic vascular diseases and congestive heart failure.

Epoprostenol was approved for IV use in the treatment of PPH by the FDA in December 1995. Continuous IV epoprostenol therapy also improves exercise capacity and cardiopulmonary hemodynamics in patients with pulmonary hypertension due to scleroderma.

Nebulized epoprostenol solutions have been effective in clinical trials, but more study is needed.

The FDA approved epoprostenol for the treatment of pulmonary hypertension in scleroderma patients in April 2000.

Indications

1. pulmonary hypertension
2. pulmonary hypertension diagnosis
3. scleroderma (systemic sclerosis)

For the treatment of pulmonary hypertension

for long-term intravenous treatment of adult patients with NYHA Class III or IV primary pulmonary hypertension or adults with pulmonary hypertension due to scleroderma (systemic sclerosis)

Side Effects

1. abdominal pain
2. agitation
3. anemia
4. anorexia
5. anxiety
6. back pain
7. bleeding
8. bradycardia
9. chest pain (unspecified)
10. chills
11. diaphoresis
12. diarrhea
13. dizziness
14. dyspepsia
15. dyspnea
16. fever
17. flushing
18. headache
19. heart failure
20. hepatic failure
21. hyperesthesia
22. hyperthyroidism
23. hypotension
24. infection
25. musculoskeletal pain
26. myalgia
27. nausea
28. pancytopenia
29. paresthesias
30. pulmonary edema
31. pulmonary embolism
32. rash
33. sinus tachycardia
34. skin ulcer
35. splenomegaly
36. tremor
37. urticaria
38. vomiting

Monitoring Parameters

• blood pressure

Contraindications

• abrupt discontinuation
• bleeding
• breast-feeding
• heart failure
• hypotension
• pregnancy
• pulmonary edema
• thromboembolic disease

Interactions

• Acebutolol
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