Enfortumab vedotin Brand Name– PADCEV
What is Enfortumab vedotin
Enfortumab vedotin is an antibody-drug conjugate that targets Nectin-4, an adhesion protein located on the surface of cells.
It is indicated for the treatment of adult patients with locally advanced or metastatic urothelial cancer who have previously received a PD-1 or PD-L1 inhibitor, and a platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced, or metastatic setting.
In a multicenter, noncomparative trial, it was associated with peripheral neuropathy, ocular disorders, and skin reactions in approximately half of the patients who received treatment.
It has not been studied in patients with moderate or severe hepatic impairment and should be avoided under these circumstances
Indications
- urothelial carcinoma
For the treatment of urothelial carcinoma
for the treatment of locally advanced or metastatic urothelial carcinoma in patients who have previously received a PD-1 or PD-L1 inhibitor, and a platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced, or metastatic setting
Side Effects
- acneiform rash
- alopecia
- anemia
- anorexia
- anorexia
- antibody formation
- asthenia
- asthenia
- blepharitis
- blurred vision
- bullous rash
- colitis
- conjunctivitis
- diabetic ketoacidosis
- diarrhea
- diarrhea
- dysgeusia
- enterocolitis
- erythema
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fatigue
- hyperglycemia
- hypoesthesia
- hypokalemia
- hyponatremia
- hypophosphatemia
- infection
- infection
- injection site reaction
- keratitis
- keratopathy
- lacrimation
- leukopenia
- lymphopenia
- maculopapular rash
- nausea
- nausea
- neutropenia
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- paresthesias
- peripheral neuropathy
- peripheral neuropathy
- photosensitivity
- pruritus
- pruritus
- rash
- rash
- renal failure (unspecified)
- urticaria
- vesicular rash
- visual impairment
- vomiting
- vomiting
- weakness
- xerophthalmia
- xerosis
Monitoring Parameters
- blood glucose
- pregnancy testing
Contraindications
- breast-feeding
- contraception requirements
- diabetes mellitus
- diabetic ketoacidosis
- extravasation
- hepatic disease
- hyperglycemia
- infertility
- keratitis
- male-mediated teratogenicity
- obesity
- peripheral neuropathy
- pregnancy
- pregnancy testing
- reproductive risk
- skin disease
- type 1 diabetes mellitus
- visual impairment
Interactions
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Atazanavir
- Atazanavir; Cobicistat
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Conivaptan
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Fosamprenavir
- grapefruit juice
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lopinavir; Ritonavir
- Mifepristone
- Nefazodone
- Nelfinavir
- Ombitasvir; Paritaprevir; Ritonavir
- Posaconazole
- Ribociclib
- Ribociclib; Letrozole
- Ritonavir
- Saquinavir
- Telithromycin
- Tipranavir
- Tucatinib
- Voriconazole
