Enasidenib Brand Name– IDHIFA
What is Enasidenib
Enasidenib is an oral isocitrate dehydrogenase-2 (IDH2) inhibitor approved for the treatment of adult patients with relapsed or refractory acute myelogenous leukemia (AML) with an IDH2 mutation as detected by an FDA-approved test.
Enasidenib targets mutant IDH2 variants resulting in increased myeloid differentiation and mature myeloid cell counts in IDH2-mutated AML.
Differentiation syndrome has been reported with enasidenib, this syndrome can be fatal if untreated.
Corticosteroid therapy and hemodynamic monitoring are indicated if differentiation syndrome is suspected.
Indications
- acute myelogenous leukemia (AML)
For the treatment of acute myelogenous leukemia (AML)
The FDA has designated enasidenib as an orphan drug for the treatment of AML.
for the treatment of relapsed or refractory AML with an isocitrate dehydrogenase-2 (IDH2) mutation
Side Effects
- acute respiratory distress syndrome (ARDS)
- anorexia
- anorexia
- bone pain
- diarrhea
- diarrhea
- differentiation syndrome
- dysgeusia
- dyspnea
- fever
- hyperbilirubinemia
- hyperbilirubinemia
- hypocalcemia
- hypocalcemia
- hypokalemia
- hypokalemia
- hypophosphatemia
- hypophosphatemia
- hypoxia
- leukocytosis
- leukocytosis
- lymphadenopathy
- nausea
- nausea
- nephrotoxicity
- pericardial effusion
- peripheral edema
- pleural effusion
- pulmonary edema
- pulmonary toxicity
- tumor lysis syndrome (TLS)
- vomiting
- vomiting
- weight gain
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
- serum bilirubin
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- breast-feeding
- contraception requirements
- differentiation syndrome
- fever
- hepatic disease
- hepatotoxicity
- infertility
- leukocytosis
- male-mediated teratogenicity
- nephrotoxicity
- pericardial effusion
- peripheral edema
- pleural effusion
- pregnancy
- pregnancy testing
- pulmonary toxicity
- reproductive risk
- respiratory distress syndrome
- tumor lysis syndrome (TLS)
Interactions
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etonogestrel
- Leuprolide; Norethindrone
- Levonorgestrel
- Mestranol; Norethindrone
- Non-oral combination contraceptives
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Segesterone Acetate; Ethinyl Estradiol
