Eletriptan

Eletriptan Brand Name– Relpax

What is Eletriptan

Eletriptan is an oral serotonin (5HT_1B/1D) receptor agonist (triptan) indicated for the acute treatment of migraine with or without aura in adults.

Eletriptan is for use only after a clear diagnosis of migraine has been established. It is not indicated for migraine prophylaxis. The safety and effectiveness of eletriptan have not been established for cluster headache. The safety of treating an average of more than 3 migraine attacks in a 30-day period has not been established.

Results from comparative studies between oral eletriptan and sumatriptan indicate that eletriptan 40 mg was superior to sumatriptan 50 or 100 mg in headache response rate at 1 or 2 hours, pain-free response rate, and functional improvement; patient acceptability of eletriptan 40 or 80 mg was superior to the 50 mg dose of sumatriptan.

Indications

• migraine

For the treatment of acute migraine attacks with or without aura

Side Effects

1. abdominal pain
2. agitation
3. alopecia
4. amnesia
5. anaphylactoid reactions
6. anemia
7. angina
8. angioedema
9. anorexia
10. anxiety
11. aphasia
12. appetite stimulation
13. arrhythmia exacerbation
14. arthralgia
15. asthenia
16. ataxia
17. atopic dermatitis
18. atrial fibrillation
19. AV block
20. back pain
21. bone pain
22. bowel ischemia
23. bradycardia
24. bronchospasm
25. chest pain (unspecified)
26. chest pressure syndrome
27. chills
28. colitis
29. confusion
30. conjunctivitis
31. constipation
32. coronary vasospasm
33. cough
34. cyanosis
35. depression
36. diarrhea
37. diplopia
38. dizziness
39. drowsiness
40. dysarthria
41. dysgeusia
42. dyspepsia
43. dysphagia
44. dyspnea
45. dystonic reaction
46. edema
47. elevated hepatic enzymes
48. emotional lability
49. epistaxis
50. eructation
51. esophagitis
52. euphoria
53. exfoliative dermatitis
54. fever
55. flatulence
56. flushing
57. gastritis
58. gingivitis
59. glossitis
60. goiter
61. halitosis
62. hallucinations
63. headache
64. hematemesis
65. hiccups
66. hyperalgesia
67. hyperbilirubinemia
68. hyperesthesia
69. hyperglycemia
70. hyperhidrosis
71. hyperkinesis
72. hypersalivation
73. hypertension
74. hyperthermia
75. hypertonia
76. hyperventilation
77. hypoesthesia
78. hypotension
79. hypothermia
80. impotence (erectile dysfunction)
81. increased urinary frequency
82. influenza
83. insomnia
84. intracranial bleeding
85. lacrimation
86. laryngitis
87. leukopenia
88. leukorrhea
89. lymphadenopathy
90. maculopapular rash
91. malaise
92. mania
93. mastalgia
94. memory impairment
95. menorrhagia
96. menstrual irregularity
97. myalgia
98. myasthenia
99. myocardial infarction
100. myopathy
101. nausea
102. ocular hemorrhage
103. ocular pain
104. otalgia
105. palpitations
106. paresthesias
107. parosmia
108. peripheral edema
109. peripheral vasoconstriction
110. pharyngitis
111. photophobia
112. polydipsia
113. polyuria
114. pruritus
115. psoriasis
116. ptosis
117. purpura
118. rash
119. rhinitis
120. seizures
121. serotonin syndrome
122. sinus tachycardia
123. sinusitis
124. skin discoloration
125. stomatitis
126. stroke
127. syncope
128. thyroid adenoma
129. tinnitus
130. tremor
131. urticaria
132. vaginitis
133. ventricular fibrillation
134. ventricular tachycardia
135. vertigo
136. visual impairment
137. vomiting
138. weight gain
139. weight loss
140. withdrawal
141. xerophthalmia
142. xerosis
143. xerostomia
144. yawning

Monitoring Parameters

• ECG
• LFTs

Contraindications

• angina
• basilar/hemiplegic migraine
• breast-feeding
• cardiac arrhythmias
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• geriatric
• hepatic disease
• hypertension
• ischemic colitis
• myocardial infarction
• obesity
• peripheral vascular disease
• pregnancy
• Raynaud’s phenomenon
• stroke
• tobacco smoking
• vasospastic angina
• Wolff-Parkinson-White syndrome

Interactions

• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Tramadol
• Alfentanil
• Almotriptan
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Amprenavir
• Aprepitant, Fosaprepitant
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Boceprevir
• Bromocriptine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Cabozantinib
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Ceritinib
• Chloramphenicol
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clomipramine
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Conivaptan
• Crizotinib
• Cyclosporine
• Dabrafenib
• Daclatasvir
• Danazol
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Desipramine
• Desvenlafaxine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextroamphetamine
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Diphenhydramine; Hydrocodone; Phenylephrine
• Doxepin
• Dronedarone
• Droxidopa
• Duloxetine
• Duvelisib
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elbasvir; Grazoprevir
• Elexacaftor; tezacaftor; ivacaftor
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Encorafenib
• Ergot alkaloids
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Etravirine
• Fedratinib
• Fenfluramine
• Fentanyl
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluvoxamine
• Fosamprenavir
• Frovatriptan
• Glecaprevir; Pibrentasvir
• grapefruit juice
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Homatropine; Hydrocodone
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Idelalisib
• Imatinib
• Imipramine
• Indinavir
• Isavuconazonium
• Isocarboxazid
• Itraconazole
• Ivacaftor
• Ivosidenib
• Ixabepilone
• Ketoconazole
• Lasmiditan
• Lefamulin
• Letermovir
• Levomilnacipran
• Levorphanol
• Linezolid
• Lisdexamfetamine
• Lithium
• Lopinavir; Ritonavir
• Lorcaserin
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Meperidine
• Meperidine; Promethazine
• Methadone
• Methamphetamine
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methylene Blue
• Mifepristone
• Milnacipran
• Mirtazapine
• Mitotane
• Morphine
• Morphine; Naltrexone
• Nalbuphine
• Naproxen; Sumatriptan
• Naratriptan
• Nefazodone
• Nelfinavir
• Netupitant, Fosnetupitant; Palonosetron
• Nilotinib
• Nortriptyline
• Ombitasvir; Paritaprevir; Ritonavir
• Oritavancin
• Oxycodone
• Oxymorphone
• Ozanimod
• Paroxetine
• Pazopanib
• Perphenazine; Amitriptyline
• Phenelzine
• Posaconazole
• Propranolol
• Protease inhibitors
• Protriptyline
• Quinine
• Rasagiline
• Remifentanil
• Reserpine
• Ribociclib
• Ribociclib; Letrozole
• Ritonavir
• Rizatriptan
• Sapropterin
• Saquinavir
• Selegiline
• Sertraline
• Sibutramine
• Simeprevir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sumatriptan
• Tapentadol
• Tedizolid
• Telaprevir
• Telithromycin
• Telotristat Ethyl
• Tezacaftor; Ivacaftor
• Tipranavir
• Tramadol
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Tricyclic antidepressants
• Trimipramine
• Tucatinib
• Vemurafenib
• Venlafaxine
• Verapamil
• Vilazodone
• Voriconazole
• Vortioxetine
• Zolmitriptan
• Zonisamide