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Edrophonium Brand Names- Enlon | Reversol | Tensilon
What is Edrophonium
Edrophonium is a rapid-acting, short-duration, parenteral cholinesterase inhibitor.
It is the drug of choice for diagnosing myasthenia gravis because of its rapid onset of action and reversibility.
Other uses include assessing cholinesterase inhibitor therapy, differentiating cholinergic and myasthenic crises, and reversing the effects of nondepolarizing neuromuscular blockers after surgery.
Edrophonium has been used to terminate paroxysmal atrial tachycardia, but alternative therapies have replaced edrophonium for this use. In combination with atropine sulfate, edrophonium is used adjunctively to treat respiratory depression associated with curare overdosage.
Edrophonium was approved by the FDA in 1951.
Indications
- myasthenia gravis
- myasthenia gravis diagnosis
- myasthenic crisis diagnosis
- neuromuscular blockade reversal
- paroxysmal supraventricular tachycardia (PSVT)
For myasthenia gravis diagnosis
Side Effects
- abdominal pain
- bradycardia
- bronchial secretions
- cardiac arrest
- conjunctival hyperemia
- diaphoresis
- diarrhea
- diplopia
- dysarthria
- dysphagia
- dysphonia
- hypersalivation
- hypotension
- increased urinary frequency
- lacrimation
- laryngospasm
- miosis
- nausea
- respiratory arrest
- respiratory depression
- seizures
- vomiting
- weakness
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- asthma
- AV block
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- cholinesterase inhibitor toxicity
- GI obstruction
- hyperthyroidism
- hypotension
- ileus
- labor
- peptic ulcer disease
- pregnancy
- sulfite hypersensitivity
- urinary tract obstruction
Interactions
- Ambenonium Chloride
- Amifampridine
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Articaine; Epinephrine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Chloroprocaine
- Cholinergic agonists
- Clomipramine
- Cocaine
- Desipramine
- Dextromethorphan; Quinidine
- Dicyclomine
- Digoxin
- Disopyramide
- Doxepin
- Etomidate
- Fospropofol
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Halogenated Anesthetics
- Homatropine; Hydrocodone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Imipramine
- Indacaterol; Glycopyrrolate
- Ketamine
- Levobupivacaine
- Lidocaine
- Lidocaine; Prilocaine
- Maprotiline
- Mepivacaine
- Mepivacaine; Levonordefrin
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methscopolamine
- Neostigmine
- Nonsteroidal antiinflammatory drugs
- Nortriptyline
- Oxybutynin
- Perphenazine; Amitriptyline
- Physostigmine
- Prilocaine
- Prilocaine; Epinephrine
- Procainamide
- Procaine
- Propantheline
- Propofol
- Protriptyline
- Pyridostigmine
- Quinidine
- Quinine
- Ropivacaine
- Scopolamine
- Tetracaine
- Tricyclic antidepressants
- Trihexyphenidyl
- Trimipramine
